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    Imidazole derivatives, process for the preparation of the same and antiulcer agents containing the same
    2.
    发明公开
    Imidazole derivatives, process for the preparation of the same and antiulcer agents containing the same 失效
    咪唑ivate ivate ivate。。。。。。。。。。。。。。。。。。。。。

    公开(公告)号：EP0412529A1

    公开(公告)日：1991-02-13

    申请号：EP90115236.3

    申请日：1990-08-08

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Okabe, Susumu, 287-5, Shingoryouguchi-cho ,  Masaki, Mitsuo ,  Yamakawa, Tomio ,  Matsukura, Hitoshi ,  Nomura, Yustaka

    IPC分类号： C07D233/84 ,  A61K31/415

    CPC分类号： C07D233/84

    摘要： Disclosed are novel imidazole derivatives having the formula:
    wherein R¹ is hydrogen or an alkyl group having 1-6 carbon atoms, R² is an alkyl group having 2-6 carbon atoms substi­tuted with an alkoxy group having 1-4 carbon atoms, each of R³, R⁴, R⁵ and R⁶ independently is hydrogen, a halogen, an alkyl group having 1-6 carbon atoms, an alkoxy group having 1-6 carbon atoms, a fluorine-substituted alkyl group having 1-6 carbon atoms, or a fluorine-substituted alkoxy group having 1-6 carbon atoms. The new imidazole derivatives are effective particularly as anti-ulcer agents.

    摘要翻译： 公开了具有下式的新型咪唑衍生物：其中R 1是氢或具有1-6个碳原子的烷基，其中R 2是具有2-6个碳原子的烷基， 1-4个碳原子，R 3，R 4，R 5和R 6各自独立地是氢，卤素，具有1-6个碳原子的烷基，具有1- 6个碳原子，具有1-6个碳原子的氟取代的烷基或具有1-6个碳原子的氟取代的烷氧基。 新的咪唑衍生物特别有效地用作抗溃疡剂。

    Novel imidazole derivatives
    4.
    发明公开
    Novel imidazole derivatives 失效
    Imidazolderivate，

    公开(公告)号：EP0354788A1

    公开(公告)日：1990-02-14

    申请号：EP89308119.0

    申请日：1989-08-10

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Okabe, Susumu 287-5, Shingoryouguchi-cho ,  Masaki, Mitsuo ,  Yamakawa, Tomio ,  Matsukura, Hitoshi ,  Nomura, Yutaka

    IPC分类号： C07D233/84 ,  C07D235/28

    CPC分类号： C07D235/28 ,  C07D233/84

    摘要： Disclosed are novel imidazole derivatives having the formula:
    wherein R 1 and R 2 are H, alkyl, cycloalkyl, aryl, aralkyl or halogen-substituted alkyl, or R 1 and R 2 are combined to form a heterocyclic ring; R 3 , R 4 , R 5 and R 6 are H, halogen, alkoxy, aralkyloxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, or fluorine substituted-alkoxy, or R 3 is combined with R 2 to form a heterocyclic ring; R 8 and R 9 are H, halogen, alkoxy, alkyl, alkoxycarbonyl, nitro, amino, acyl, fluorine substituted-alkyl, fluorine substituted-alkoxy, or aryl group which may have a substitutent, or R 8 and R 9 are combined to form an alicyclic ring; R 7 is, where R 8 and R 9 are not combined, H, and, where R 8 and R 9 are combined, H, alkyl which may have a substitutent, aryl which may have a substitutent, arylcarbonyl which may have a substitutent, or a sulfur-containing heterocyclic group; and n is 0 or 1. The new imidazole derivatives are effective particularly as anti-ulcer agents.

    摘要翻译： 公开了具有下式的新型咪唑衍生物：其中R 1和R 2是H，烷基，环烷基，芳基，芳烷基或卤素取代的烷基，或R 1和R 2相结合的 形成杂环; R 3，R 4，R 5和R 6是H，卤素，烷氧基，芳烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的烷基或氟取代的烷氧基 R 3与R 2结合形成杂环; R 8和R 9是可以具有取代基的H，卤素，烷氧基，烷基，烷氧基羰基，硝基，氨基，酰基，氟取代的烷基，氟取代的烷氧基或芳基，或R 8， 和R 9结合形成脂环族环; R 7是其中R 8和R 9不组合的化合物，其中R 8和R 9结合，H可以具有取代基的烷基，其可以具有 可以具有取代基的取代基芳基羰基或含硫杂环基; 并且n为0或1.新的咪唑衍生物特别用作抗溃疡剂。

    Amino-alcohol derivatives and processes for their preparation
    5.
    发明公开
    Amino-alcohol derivatives and processes for their preparation 失效
    Aminoalkohol-Derivate und Verfahren zu ihrer Herstellung。

    公开(公告)号：EP0177245A2

    公开(公告)日：1986-04-09

    申请号：EP85306767.6

    申请日：1985-09-24

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Masaki, Mitsuo ,  Shinozaki, Haruhiko ,  Satoh, Masuru ,  Moritoh, Naoya ,  Hashimoto, Koichi ,  Kamishiro, Toshiro

    IPC分类号： C07D295/12 ,  C07C215/56 ,  C07C217/44

    CPC分类号： C07D295/13

    摘要： Amino-alcohol derivatives of the formula,
    where R, is a straight or branched alkyl group having 3 to 8 carbon atoms, R 2 and R 3 are each a lower alkyl group, or R 2 and R 3 form a 5- to 7-membered ring together with the adjacent nitrogen atom which may have an oxygen atom attached thereto, R. is a hydrogen atom or a lower alkyl group, R 5 is a hydrogen atom or a lower alkyl group, X is a hydrogen or halogen atom or a lower alkyl or lower alkoxy group, and n is an integer of 2 or 3, and acid addition salts thereof, are effectively useful as medicines and agricultural chemicals. Processes are also disclosed for preparing such compounds.

    摘要翻译： 其中R 1是具有3至8个碳原子的直链或支链烷基，R 2和R 3各自是低级烷基，或者R 2和R 3形成5-至7-元环的下式的氨基醇衍生物 与可能具有氧原子的相邻氮原子一起，R4是氢原子或低级烷基，R5是氢原子或低级烷基，X是氢或卤素原子或低级烷基或低级烷基 烷氧基，n为2或3的整数，其酸加成盐可有效用作药物和农药。 还公开了制备这些化合物的方法。

    Pharmaceutical composition for protection of brain cells
    8.
    发明公开
    Pharmaceutical composition for protection of brain cells 失效
    Pharmazeutische Zusammensetzung zum Schutz von Gehirnzellen。

    公开(公告)号：EP0256890A2

    公开(公告)日：1988-02-24

    申请号：EP87307322.5

    申请日：1987-08-19

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Kogure, Kyuya ,  Masaki, Mitsuo

    IPC分类号： A61K31/495

    CPC分类号： A61K31/495

    摘要： A pharmaceutical composition for protection of brain cells containing as an active component a piperazine derivative having the formula:
    wherein R¹ is hydrogen or a lower alkyl group, R² is hy­droxyl, an aralkyloxy group, a lower alkoxy group having 1-5 carbon atoms or a lower alkenyloxy group having 3-5 carbon atoms, R³ is hydrogen, an aralkyloxy group, a lower alkoxy group having 1-5 carbon atoms or a lower alkenyloxy group having 3-5 carbon atoms and R⁴ is hydro­gen or a lower alkoxy group having 1-5 carbon atoms.

    摘要翻译： 一种用于保护含有下式的哌嗪衍生物作为活性成分的脑细胞的药物组合物：其中R 1为氢或低级烷基，R 2为羟基，芳烷氧基，低级烷氧基 具有1-5个碳原子的基团或具有3-5个碳原子的低级烯氧基，R 3是氢，芳烷氧基，具有1-5个碳原子的低级烷氧基或具有3-5个碳的低级烯氧基 原子和R 4是氢或具有1-5个碳原子的低级烷氧基。

    Novel quinaldinamide derivatives and their preparations
    9.
    发明公开
    Novel quinaldinamide derivatives and their preparations 失效
    2-Chinolincarbonsäureamid-Derivate und ihre Herstellung。

    公开(公告)号：EP0256181A1

    公开(公告)日：1988-02-24

    申请号：EP86306294.9

    申请日：1986-08-14

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Masaki, Mitsuo ,  Shinozaki, Haruhiko ,  Satoh, Masaru ,  Moritoh, Naoya ,  Hashimoto, Koichi ,  Kamishiro, Toshiro

    IPC分类号： C07D215/48 ,  A61K31/47

    CPC分类号： C07D215/48 ,  Y10S514/906

    摘要： A novel quinaldinamide derivative having the formula:
    wherein each of R 1 and R 2 independently represents a lower alkyl group or R 1 and R 2 are combined together with the adjacent nitrogen atom to form a 5 - 7 membered ring; and X represents the hydrogen atom, a lower alkyl group or a lower alkoxy group, and its acid-addition salt, which show prominent central muscle relaxant effect, namely, rigidity relieving effect on anemic decerebrated rigidity.

    摘要翻译： 具有下式的新颖的喹哪啶衍生物：其中R 1和R 2各自独立地代表低级烷基或R 1和R 2与相邻的氮原子一起形成 5-7元环; X表示氢原子，低级烷基或低级烷氧基，及其酸加成盐，具有显着的中枢肌松弛作用，即缓解刚性减轻刚性的刚性。

    Alkylenediamine derivatives
    10.
    发明公开
    Alkylenediamine derivatives 失效
    Alkylendiamin衍。

    公开(公告)号：EP0235942A1

    公开(公告)日：1987-09-09

    申请号：EP87300850.2

    申请日：1987-01-30

    申请人： NIPPON CHEMIPHAR CO., LTD.

    发明人： Masaki, Mitsuo ,  Shinozaki, Haruhiko ,  Satoh, Masaru ,  Mortioh, Naoya ,  Hashimoto,Koichi ,  Kamishiro, Toshiro

    IPC分类号： C07D295/12 ,  A61K31/395

    CPC分类号： C07D295/13

    摘要： Novel alkylenediamine derivative having the formula (I):
    wherein A is a group having the formula (II):
    (wherein R 1 is an aliphatic hydrocarbon group, an alicyclic group, an aryl group, or an aralkyl group; R 2 is an aliphatic hydrocarbon group, en alkoxy group, an aliphatic hydrocarbon group containing an ester or ether bonding, or an aryloxy group; and each of m and n is an integer of 0 to 2, provided that m + n does not exceed 3) and B is hoydrogen, or
    A is a group having the formula (III):
    (wherein R 3 has the same meaning as that of R 1 and k is an integer of 0 to 3) and B is a group repesenting by the formula (IV):
    wherein R 4 has almost the same meaning as that of R 2 , p is an integer of 2 to 6, and q is an integer of 4 to 7.
    These compounds are useful as glutamate blockers.

    摘要翻译： 具有式（I）的新型亚烷基二胺衍生物：其中A是具有式（II）的基团：R 1（CH 2）m -CH（R 2） - （CH 2）n - （II） （其中R 1是脂族烃基，脂环基，芳基或芳烷基; R 2是脂族烃基，en烷氧基，含有酯或醚键的脂族烃基， 或芳氧基; m和n分别为0〜2的整数，条件是m + n不超过3），B为氢氧根，或A为具有式（III）的基团：R 3 - （CH 2）k - （III）（其中R 3具有与R 1相同的含义，k为0至3的整数），B为式（Ⅳ）表示的基团：R 其中R 4与R 2具有几乎相同的含义，p为2〜6的整数，q为4〜7的整数。这些化合物可用作谷氨酸 阻滞剂。