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公开(公告)号：EP1591447B1
公开(公告)日：2014-11-26
申请号：EP03778894.0
申请日：2003-12-12
申请人： NOF CORPORATION
发明人： KUBO, Kazuhiro , ITOH, Chika , OHHASHI, Syunsuke , YASUKOHCHI, Tohru , OHKAWA, Yusuke , KIKUCHI, Hiroshi DAIICHI PHARMACEUTICAL CO., LTD. , SUZUKI, Norio DAIICHI PHARMACEUTICAL CO., LTD. , TAKAHASHI, Miho DAIICHI PHARMACEUTICAL CO., LTD. , YAMAUCHI, Hitoshi DAIICHI PHARMACEUTICAL CO., LTD
IPC分类号： C07F9/10 , A61K47/24 , A61K9/127 , A61P35/00 , B01F17/14 , A61K8/14 , A61K8/55 , A61Q19/00 , C08G65/335 , A61K9/00 , C08G65/26
CPC分类号： A61K9/127 , A61K8/14 , A61K8/553 , A61K9/0014 , A61K9/1273 , A61K47/24 , A61Q19/00 , C07F9/10 , C08G65/2609 , C08G65/3353 , C08G2650/34
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公开(公告)号：EP1591447A1
公开(公告)日：2005-11-02
申请号：EP03778894.0
申请日：2003-12-12
发明人： KUBO, Kazuhiro , ITOH, Chika , OHHASHI, Syunsuke , YASUKOHCHI, Tohru , OHKAWA, Yusuke , KIKUCHI, Hiroshi DAIICHI PHARMACEUTICAL CO., LTD. , SUZUKI, Norio DAIICHI PHARMACEUTICAL CO., LTD. , TAKAHASHI, Miho DAIICHI PHARMACEUTICAL CO., LTD. , YAMAUCHI, Hitoshi DAIICHI PHARMACEUTICAL CO., LTD
CPC分类号： A61K9/127 , A61K8/14 , A61K8/553 , A61K9/0014 , A61K9/1273 , A61K47/24 , A61Q19/00 , C07F9/10 , C08G65/2609 , C08G65/3353 , C08G2650/34
摘要： A phospholipid derivative represented by the following formula (1):
wherein [PG]k represents a residue of polyglycerin having a polymerization degree of k, wherein k is 2 to 50, R 1 CO and R 2 CO independently represent an acyl group having 8 to 22 carbon atoms, symbol "a" independently represents an integer of 0 to 5, symbol "b" independently represents 0 or 1, M represents hydrogen atom, an alkali metal atom, an ammonium, or an organic ammonium, and k1, k2, and k3 represent numbers satisfying the following conditions: 1 ≦ k1 ≦ (k+2)/2, 0 ≦ k2, and k1 + k2 + k3 = k + 2. The phospholipid derivative is highly safe for living bodies and can be suitably utilized in drug delivery systems such as liposome, and the like.
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