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公开(公告)号：EP0998495A1
公开(公告)日：2000-05-10
申请号：EP98905006.7
申请日：1998-02-05
发明人： KRAFFT, Grant, A. , KLEIN, William, L. , CHROMY, Brett, A. , LAMBERT, Mary, P. , FINCH, Caleb, E. , MORGAN, Todd , WALS, Pat , ROZOVSKY, Irina , BARLOW, Ann
CPC分类号： C07K14/4711 , A61K38/00
摘要： The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid β protein assembled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention also provides methods for assying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
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公开(公告)号：EP0998495B1
公开(公告)日：2006-12-27
申请号：EP98905006.7
申请日：1998-02-05
发明人： KRAFFT, Grant, A. , KLEIN, William, L. , CHROMY, Brett, A. , LAMBERT, Mary, P. , FINCH, Caleb, E. , MORGAN, Todd , WALS, Pat , ROZOVSKY, Irina , BARLOW, Ann
CPC分类号： C07K14/4711 , A61K38/00
摘要： The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid beta protein assembled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention also provides methods for assying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
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公开(公告)号：EP1200470A2
公开(公告)日：2002-05-02
申请号：EP00952571.8
申请日：2000-08-04
发明人： KRAFFT, Grant, A. , KLEIN, William, L. , CHROMY, Brett, A. , LAMBERT, Mary, P. , FINCH, Caleb, E. , MORGAN, Todd , WALS, Pat , ROZOVSKY, Irina , BARLOW, Ann
CPC分类号： C07K14/4711 , A61K38/00
摘要： The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid β protein assembled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention also provides methods for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
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公开(公告)号：EP1200470B1
公开(公告)日：2004-11-24
申请号：EP00952571.8
申请日：2000-08-04
发明人： KRAFFT, Grant, A. , KLEIN, William, L. , CHROMY, Brett, A. , LAMBERT, Mary, P. , FINCH, Caleb, E. , MORGAN, Todd , WALS, Pat , ROZOVSKY, Irina , BARLOW, Ann
CPC分类号： C07K14/4711 , A61K38/00
摘要： The invention provides amyloid beta-derived dementing ligands (ADDLs) that comprise amyloid beta protein assembled into globular non-fibrillar oligomeric structures capable of activating specific cellular processes. The invention also provides methods for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDLs, and modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
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公开(公告)号：EP1551447A2
公开(公告)日：2005-07-13
申请号：EP03757505.7
申请日：2003-06-11
发明人： KLEIN, William, L. , KRAFFT, Grant, A. , LAMBERT, Mary, P. , VIOLA, Kirsten, L. , CHROMY, Brett, A. , GONG, Yue, Song , CHANG, Lei , MORGAN, Todd, E. , ROZOFSKY, Irina , FINCH, Caleb, E.
IPC分类号： A61K39/00 , A61K39/395 , C07K16/00
CPC分类号： G01N33/6896 , A61K38/00 , A61K2039/505 , C07K14/4711 , C07K16/18 , G01N2333/4709 , G01N2800/2821
摘要： The invention herein comprises antibodies that bind to amyloid beta-derived diffusible ligands (ADDLs). ADDLs comprise amyloid ß protein assembled into soluble, globular, non-fibrillar, oligomeric structures capable of activating specific cellular processes. The invention also comprises methods of using ADDL-specific antibodies for assaying the formation, presence, receptor protein binding and cellular activity of ADDLs, as well as using such antibodies to detect compounds that block the formation or activity of ADDLs, and methods of identifying such compounds. The invention further provides methods of using ADDL-specific antibodies in modulating ADDL formation and/or activity, inter alia in the treatment of learning and/or memory disorders.
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