公开(公告)号：EP3218410A1

公开(公告)日：2017-09-20

申请号：EP15798251.3

申请日：2015-11-13

申请人： Novartis AG

发明人： ABRAMS, Tinya ,  COHEN, Steven ,  DAMIANO, Jason ,  DÜRR, Clemens ,  HUBER, Thomas ,  MENEZES, Daniel ,  MILLER, Kathy ,  RENDAHL, Katherine ,  RONDEAU, Jean-michel Rene

IPC分类号： C07K16/28 ,  A61P35/00 ,  A61K47/50

CPC分类号： C07K16/28 ,  A61K31/5365 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6851 ,  C07K16/30 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/00 ,  G01N33/57492 ,  G01N2333/705

摘要： This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

摘要翻译： 该申请公开了抗P-钙粘蛋白抗体，其抗原结合片段和所述抗体或抗原结合片段的抗体药物缀合物。 本发明还涉及使用抗体，抗原结合片段和抗体药物缀合物治疗癌症的方法。 本文还公开了制备抗体，抗原结合片段和抗体药物缀合物的方法，以及使用所述抗体和抗原结合片段作为诊断试剂的方法。

公开(公告)号：EP3310813A1

公开(公告)日：2018-04-25

申请号：EP16732342.7

申请日：2016-06-17

申请人： Novartis AG

发明人： ABRAMS, Tinya ,  COHEN, Steven ,  D'ALESSIO, Joseph Anthony ,  DAMIANO, Jason ,  DURR, Clemens ,  GEIERSTANGER, Bernhard Hubert ,  HU, Qi-Ying ,  HUBER, Thomas ,  IMASE, Hidetomo ,  JIN, Yunho ,  MENEZES, Daniel ,  MILLER, Kathy ,  MOHSENI, Morvarid ,  OU, Weijia ,  RENDAHL, Katherine ,  UNO, Tetsuo ,  WAN, Yongqin ,  WANG, Xing

IPC分类号： C07K16/28 ,  A61K31/00 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/28 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：EP1989201A1

公开(公告)日：2008-11-12

申请号：EP07757005.9

申请日：2007-02-14

申请人： NOVARTIS AG

发明人： NI, Zhi-jie ,  PECCHI, Sabina ,  BURGER, Matthew ,  HAN, Wooseok ,  SMITH, Aaron ,  ATALLAH, Gordana ,  BARTULIS, Sarah ,  FRAZIER, Kelly ,  VERHAGEN, Joelle ,  ZHANG, Yanchen ,  IWANOWICZ, Ed ,  HENDRICKSON, Tom ,  KNAPP, Mark ,  MERRITT, Hanne ,  VOLIVA, Charles ,  WIESMANN, Marion ,  LEGRAND, Darren Mark ,  BRUCE, Ian ,  DALE, James ,  LAN, Jiong ,  LEVINE, Barry ,  COSTALES, Abran ,  LIU, Jie ,  PICK, Teresa ,  MENEZES, Daniel

IPC分类号： C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61K31/5025 ,  A61K31/428 ,  A61P35/00

CPC分类号： C07D487/04 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04

摘要： Phosphatidylinositol (PI) 3 kinase inhibitor compounds, their pharmaceutically acceptable salts, and prodrugs thereof; compositions of the new compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier; and uses of the new compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of proliferative diseases characterized by the abnormal activity of growth factors, protein serine/threonine kinases, phospholipid kinases, G-protein coupled receptors, and phosphatases.