公开(公告)号：EP4323526A1

公开(公告)日：2024-02-21

申请号：EP22726208.6

申请日：2022-04-15

申请人： Novartis AG

发明人： FAN, Liqiong ,  HAINZL, Dominik ,  RAMOT, Roee ,  IYER, Shwetha ,  D'ALESSIO, Joseph Anthony ,  WUERSCH, Kuno ,  PISTORIUS, Dominik ,  MANCHADO ROBLES, Eusebio ,  BUNTIN, Kathrin ,  GABRIEL, Doris ,  FESSLER, Boris ,  MAUDENS, Pierre ,  ROMANET, Vincent ,  BLUEMMEL, Anne-Sophie ,  HOFFMASTER, Keith ,  KHERA, Eshita ,  YERRAMILLI-RAO, Padmaja

IPC分类号： C12N15/52 ,  C12N9/00 ,  C12N9/02 ,  C12N9/10 ,  A01N43/00

公开(公告)号：EP4406555A3

公开(公告)日：2024-11-06

申请号：EP24177473.6

申请日：2019-12-18

申请人： Novartis AG

发明人： BURGER, Matthew ,  D'ALESSIO, Joseph Anthony ,  FLEMING, Tony ,  RAUNIYAR, Vivek ,  ROBLES, Eusebio Manchado

IPC分类号： C07K16/00 ,  C07K16/30 ,  A61K47/68 ,  C07K1/113

摘要： This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：EP4427590A2

公开(公告)日：2024-09-11

申请号：EP24176079.2

申请日：2022-04-15

申请人： Novartis AG

发明人： FAN, Liqiong ,  HAINZL, Dominik ,  RAMOT, Roee ,  IYER, Shwetha ,  D'ALESSIO, Joseph Anthony ,  WUERSCH, Kuno ,  PISTORIUS, Dominik ,  MANCHADO ROBLES, Eusebio ,  BUNTIN, Kathrin ,  GABRIEL, Doris ,  FESSLER, Boris ,  MAUDENS, Pierre ,  ROMANET, Vincent ,  BLUEMMEL, Anne-Sophie ,  HOFFMASTER, Keith ,  KHERA, Eshita ,  YERRAMILLI-RAO, Padmaja

IPC分类号： A01N43/00

CPC分类号： C12N15/52 ,  C12N9/93 ,  C12N9/1029 ,  C12R2001/0120210501 ,  C12N9/0006 ,  C12N9/0071 ,  C07K14/705 ,  C12P21/02 ,  C07K14/4722 ,  C07K16/28 ,  A61K47/6849 ,  A61K47/6865 ,  A61K47/6811 ,  A61K47/6803

摘要： This application discloses microorganisms and methods of producing GNAQ/GNA11 inhibitors and methods of making antibody drug conjugates of anti-PMEL17 antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The disclosure also relates to formulations comprising antibody drug conjugates of anti-PMEL17 antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor and methods of treating or preventing cancer using the formulations.

公开(公告)号：EP4251648A2

公开(公告)日：2023-10-04

申请号：EP21816541.3

申请日：2021-11-23

申请人： Novartis AG

发明人： D'ALESSIO, Joseph Anthony ,  KLINTER, Claudia Judith ,  MUNDT, Cornelia Anne ,  NEWCOMBE, Richard Vaughan ,  SCHWEIGHOFFER, Tamás ,  WINKELBACH, Katharina

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61P35/00

公开(公告)号：EP4406555A2

公开(公告)日：2024-07-31

申请号：EP24177473.6

申请日：2019-12-18

申请人： Novartis AG

发明人： BURGER, Matthew ,  D'ALESSIO, Joseph Anthony ,  FLEMING, Tony ,  RAUNIYAR, Vivek ,  ROBLES, Eusebio Manchado

IPC分类号： A61K39/395

CPC分类号： C07K16/3053 ,  C07K2317/5620130101 ,  A61K39/39558 ,  A61K47/6803

摘要： This application discloses anti-PMEL17 antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments conjugated to a GNAQ/GNA11 inhibitor. The invention also relates to methods of treating or preventing cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

公开(公告)号：EP3310813A1

公开(公告)日：2018-04-25

申请号：EP16732342.7

申请日：2016-06-17

申请人： Novartis AG

发明人： ABRAMS, Tinya ,  COHEN, Steven ,  D'ALESSIO, Joseph Anthony ,  DAMIANO, Jason ,  DURR, Clemens ,  GEIERSTANGER, Bernhard Hubert ,  HU, Qi-Ying ,  HUBER, Thomas ,  IMASE, Hidetomo ,  JIN, Yunho ,  MENEZES, Daniel ,  MILLER, Kathy ,  MOHSENI, Morvarid ,  OU, Weijia ,  RENDAHL, Katherine ,  UNO, Tetsuo ,  WAN, Yongqin ,  WANG, Xing

IPC分类号： C07K16/28 ,  A61K31/00 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/28 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6849 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments, particularly antibody drug conjugates comprising anti-P-cadherin antibodies conjugated to auristatin analogs. The invention also relates to methods of treating cancer using the antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.