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163 条记录 (耗时 0.028 秒)

    1,4 SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS
    1.
    发明公开
    1,4 SUBSTITUTED PYRAZOLOPYRIMIDINES AS KINASE INHIBITORS 审中-公开
    1,4-取代的吡唑并嘧啶作为激酶抑制剂

    公开(公告)号：EP1812441A1

    公开(公告)日：2007-08-01

    申请号：EP05819276.6

    申请日：2005-11-10

    申请人： Novartis AG ,  NOVARTIS-PHARMA GMBH

    发明人： SCHMIEDEBERG, Niko ,  FURET, Pascal ,  IMBACH, Patricia ,  HOLZER, Philipp

    IPC分类号： C07D487/04 ,  A61K31/519 ,  A61P35/00 ,  A61P17/00

    CPC分类号： C07D487/04

    摘要： The invention relates to 1,4-substituted pyrazolopyrimidine compounds of the formula (I), pharmaceuticals comprising a 1,4-substituted pyrazolopyrimidine compound, the use of a 1,4-substituted pyrazolopyrimidine compound in the treatment or the use thereof in the manufacture of a pharmaceutical formulation for the treatment of a disease that depends on inadequate activity of a protein kinase, methods of treatment comprising administering a 1,4-substituted pyrazolopyrimidine compound, methods for the manufacture of a novel compound of that class, and novel intermediates and partial steps for their synthesis.

    1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES
    3.
    发明公开
    1H-IMIDAZO[4,5-C]QUINOLINE DERIVATIVES IN THE TREATMENT OF PROTEIN KINASE DEPENDENT DISEASES 有权
    -1H-咪唑并[4,5-C]喹啉蛋白激酶依赖性疾病治疗

    公开(公告)号：EP1509521A2

    公开(公告)日：2005-03-02

    申请号：EP03730079.5

    申请日：2003-05-20

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： GARCIA-ECHEVERRIA, Carlos ,  CAPRARO, Hans-Georg ,  FURET, Pascal

    IPC分类号： C07D471/00

    CPC分类号： C07D471/04

    摘要： The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase dependent diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoloquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.

    ANTHRANILIC ACID AMIDES AND PHARMACEUTICAL USE THEREOF
    4.
    发明公开
    ANTHRANILIC ACID AMIDES AND PHARMACEUTICAL USE THEREOF 有权
    邻氨基和它们的药物用途

    公开(公告)号：EP1446381A1

    公开(公告)日：2004-08-18

    申请号：EP02779536.8

    申请日：2002-11-07

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： BOLD, Guido ,  FURET, Pascal ,  MANLEY, Paul, William

    IPC分类号： C07D213/38 ,  C07D213/89 ,  C07C237/40 ,  A61K31/44 ,  A61K31/165 ,  A61P35/00

    CPC分类号： C07C237/40 ,  C07D213/38 ,  C07D213/89

    摘要： The invention relates to anthranilic acid amide derivatives of formula (I), wherein Ar is represented by the subformula (Ia), wherein Ra represents H or lower alkyl, and R1 represents H or perfluoro lower alkyl, R2 represents H, halogen, C2-C7alkyl, C2-C7alkenyl or lower aklynyl; or Ar is represented by the subformula (Ib) and R1 represents perfluoro lower alkyl, and R2 represents bromo, iodo, C2-C7alkyl, C2-C7alkenyl or lower alkynyl, or R1 represents H, and R2 represents fluoro, bromo, iodo, ethyl, C5-C7alkyl, C2-C7alkenyl or lower alkynyl; to N-oxides and tautomers thereof, and to salts of such anthranilic acid amides, its N-oxides and tautomers; to processes for their preparation; to their application in the treatment of the human or animal body, to the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment especially of a neoplastic disease, such as a tumor disease, of retinopathy or age-related macular degeneration; to a method for the treatment of such diseases in animals; and to the use of such a compound - alone or in combination with one or more other pharmaceutically active compounds - for the manufacture of a pharmaceutical preparation for the treatment of a neoplastic disease, of retinopathy or age-related macular degeneration.

    INHIBITORS OF TYROSINE KINASES
    7.
    发明授权
    INHIBITORS OF TYROSINE KINASES 有权
    酪氨酸激酶抑制剂

    公开(公告)号：EP1532138B1

    公开(公告)日：2008-11-19

    申请号：EP03762632.2

    申请日：2003-07-04

    申请人： NOVARTIS AG ,  Novartis Pharma GmbH

    发明人： BREITENSTEIN, Werner ,  FURET, Pascal ,  JACOB, Sandra ,  MANLEY, Paul, William

    IPC分类号： C07D401/14

    CPC分类号： C07D401/14 ,  C07D405/14

    摘要： The invention relates to compounds of formula (I) Wherein the substituents R1, R2 and R4 have the meaning as set forth and explained in the description of the invention, to processes for the preparation of these compounds, pharmaceutical compositions containing same, the use thereof optionally in combination with one or more other pharmaceutically active compounds for the therapy of a disease which responds to an inhibition of protein kinase activity, especially a neoplastic disease, in particular leukaemia, and a method for the treatment of such disease.