公开(公告)号：EP1687305A1

公开(公告)日：2006-08-09

申请号：EP04798017.2

申请日：2004-11-19

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： CAPRARO, Hans-Georg ,  CARAVATTI, Giorgio ,  FURET, Pascal ,  GARCIA-ECHEVERRIA, Carlos ,  IMBACH, Patricia ,  STAUFFER, Frédéric

IPC分类号： C07D471/04 ,  A61K31/435 ,  A61P35/00 ,  C07D235/00 ,  C07D221/00

CPC分类号： C07D471/04

摘要： The invention relates to imidazoquinolines of formula (I) for use in the treatment of protein kinase dependent diseases; pharmaceutical preparations comprinsing an imidazoquinoline, especially for the treatment of a pretein kinase dependent disease; novel imidazoquinolines; and a process for the preparation of the novel imidazoquinilines.

公开(公告)号：EP2049502A1

公开(公告)日：2009-04-22

申请号：EP07819913.0

申请日：2007-07-25

申请人： NOVARTIS AG ,  Novartis Pharma GmbH

发明人： STAUFFER, Frédéric ,  FURET, Pascal

IPC分类号： C07D239/74 ,  C07D239/84 ,  C07D401/04 ,  C07D405/04 ,  C07D401/14 ,  C07D409/04 ,  C07D403/04 ,  C07D409/14 ,  A61K31/517 ,  A61P29/02 ,  A61P35/00 ,  A61P37/08

CPC分类号： C07D239/74 ,  C07D239/84 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04 ,  C07D409/14

摘要： The invention relates to compounds of the formula (I), which are appropriate for the treatment of kinase, e.g. PI3K-related, diseases, such as proliferative diseases, inflammatory diseases, obstructive airways disorders and transplantation related diseases.

公开(公告)号：EP1689747A1

公开(公告)日：2006-08-16

申请号：EP04803196.7

申请日：2004-11-19

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： CAPRARO, Hans-Georg ,  FURET, Pascal ,  GARCIA-ECHEVERRIA, Carlos ,  STAUFFER, Frédéric

IPC分类号： C07D471/04 ,  A61K31/41 ,  A61P35/00 ,  C07D235/00 ,  C07D221/00

CPC分类号： C07D471/04 ,  A61K31/41

摘要： The invention relates to the use of imidazoquinolines and salts thereof in the treatment of protein kinase diseases and for the manufacture of pharmaceutical preparations for the treatment of said diseases, imidazoquinolines for use in the treatment of protein kinase dependent diseases, a method of treatment against said diseases, comprising administering the imidazoquinolines to a warm-blooded animal, especially a human, pharmaceutical preparations comprising an imidazoquinoline, especially for the treatment of a protein kinase dependent disease, novel imidazoquinolines, and a process for the preparation of the novel imidazoquinolines.

公开(公告)号：EP1687305B1

公开(公告)日：2008-07-09

申请号：EP04798017.2

申请日：2004-11-19

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： CAPRARO, Hans-Georg ,  CARAVATTI, Giorgio ,  FURET, Pascal ,  GARCIA-ECHEVERRIA, Carlos ,  IMBACH, Patricia ,  STAUFFER, Frédéric

IPC分类号： C07D471/04 ,  A61K31/435 ,  A61P35/00

CPC分类号： C07D471/04

摘要： The invention relates to imidazoquinolines of formula (I) for use in the treatment of protein kinase dependent diseases; pharmaceutical preparations comprinsing an imidazoquinoline, especially for the treatment of a pretein kinase dependent disease; novel imidazoquinolines; and a process for the preparation of the novel imidazoquinilines.

公开(公告)号：EP1888578A2

公开(公告)日：2008-02-20

申请号：EP06753710.0

申请日：2006-05-18

申请人： Novartis AG ,  NOVARTIS-PHARMA GMBH

发明人： GARCIA-ECHEVERRIA, Carlos ,  STAUFFER, Frédéric ,  FURET, Pascal

IPC分类号： C07D471/04 ,  A61K31/4188 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D471/04

摘要： The invention relates to novel organic compounds of formula (I) processes for the preparation thereof, the application thereof in a process for the treatment of the human or animal body, the use thereof - alone or in combination with one or more other pharmaceutically active compounds - for the treatment of an inflammatory or obstructive airway disease, such as asthma, disorders commonly occurring in connection with transplantation, or a proliferative disease, such as a tumor disease.

公开(公告)号：EP2790705B1

公开(公告)日：2017-12-06

申请号：EP12818825.7

申请日：2012-12-14

申请人： Novartis AG

发明人： COOKE, Nigel Graham ,  FERNANDES GOMES DOS SANTOS, Paulo Antonio ,  FURET, Pascal ,  HEBACH, Christina ,  HÖGENAUER, Klemens ,  HOLLINGWORTH, Gregory ,  KALIS, Christoph ,  LEWIS, Ian ,  SMITH, Alexander Baxter ,  SOLDERMANN, Nicolas ,  STAUFFER, Frédéric ,  STRANG, Ross ,  STOWASSER, Frank ,  TUFILLI, Nicola ,  VON MATT, Anette ,  WOLF, Romain ,  ZECRI, Frédéric

IPC分类号： A61K31/517 ,  A61K31/519 ,  A61P33/00

CPC分类号： A61K31/519 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/551 ,  C07D239/74 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D413/14 ,  C07D487/08 ,  Y02A50/409 ,  Y02A50/411 ,  Y02A50/414

摘要： The invention relates to new uses of PI3K inhibitors, wherein said inhibitors have an inhibitory action on the PI3K isoform delta for the treatment of immunopathology in a subject suffering from a disease or disorder selected from malaria, leishmaniasis, trypanosomiasis, toxoplasmosis and/or neurocysticercosis, via functional inhibition of TLR9 of the infected subject.

公开(公告)号：EP2768813A1

公开(公告)日：2014-08-27

申请号：EP12791859.7

申请日：2012-10-19

申请人： Novartis AG

发明人： FURET, Pascal ,  HEBACH, Christina ,  HÖGENAUER, Klemens ,  HOLLINGWORTH, Gregory ,  LEWIS, Ian ,  SMITH, Alexander, Baxter ,  SOLDERMANN, Nicolas ,  STAUFFER, Frédéric ,  WOLF, Romain ,  ZECRI, Frédéric

IPC分类号： C07D239/74 ,  C07D401/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D487/08 ,  A61K31/517 ,  A61P37/00 ,  A61P29/00 ,  A61P11/00 ,  A61P35/00

CPC分类号： C07D401/04 ,  C07D239/74 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D487/08

摘要： The invention relates to substituted quinazoline derivative of the formula (I), wherein A, X
1 , X
2 , X
3 , X
4 and R
5 are as defined in the description. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of the PI3K enzymes.

公开(公告)号：EP2817307A1

公开(公告)日：2014-12-31

申请号：EP13717317.5

申请日：2013-02-22

申请人： Novartis AG

发明人： CARAVATTI, Giorgio ,  FAIRHURST, Robin Alec ,  FURET, Pascal ,  STAUFFER, Frédéric ,  SEILER, Frank Hans ,  RUEEGER, Heinrich ,  MCCARTHY, Clive

IPC分类号： C07D413/14 ,  A61K31/5377 ,  A61P35/00

CPC分类号： C07D498/04 ,  A61K31/5377 ,  A61K45/06 ,  C07D413/14

摘要： The present invention relates to oxazolidin-2-one subsituted pyrimidine compounds that act as PI3K (phosphatidylinositol-3-kinase) inhibitors, as well as pharmaceutical compositions thereof, methods for their manufacture and uses for the treatment of conditions, diseases and disorders dependent on PI3K.

公开(公告)号：EP1888578B8

公开(公告)日：2013-04-03

申请号：EP06753710.0

申请日：2006-05-18

申请人： Novartis AG

发明人： GARCIA-ECHEVERRIA, Carlos ,  STAUFFER, Frédéric ,  FURET, Pascal

IPC分类号： C07D471/04 ,  A61K31/4188 ,  A61P35/00 ,  A61P29/00

CPC分类号： C07D471/04

公开(公告)号：EP2250152A1

公开(公告)日：2010-11-17

申请号：EP09715302.7

申请日：2009-02-26

申请人： Novartis AG

发明人： AMSTUTZ, René ,  BOLD, Guido ,  COTESTA, Simona ,  JAHNKE, Wolfgang ,  MARZINZIK, Andreas ,  MUELLER-HARTWIEG, Constanze ,  OFNER, Silvio ,  STAUFFER, Frédéric ,  ZIMMERMANN, Johann

IPC分类号： C07D215/48 ,  C07D401/04 ,  C07F9/60 ,  C07D215/18 ,  C07D409/04 ,  C07D409/14 ,  C07D417/12 ,  A61K31/675 ,  A61P35/04

CPC分类号： C07D215/48 ,  C07D215/18 ,  C07D401/04 ,  C07D409/04 ,  C07D409/14 ,  C07D417/12 ,  C07F9/60 ,  C07F9/65583 ,  C07F9/65586

摘要： The invention relates to a compound of formula (I) wherein the substituents are as described in the specification, which are useful as farnesyl pyrophosphate synthase modulators, e.g. in the treatment of proliferative diseases, to methods of manufacturing such compounds and to intermediates thereof.