公开(公告)号：EP1497287A4

公开(公告)日：2007-07-11

申请号：EP03746614

申请日：2003-04-04

申请人： NOVARTIS VACCINES & DIAGNOSTIC

发明人： RENHOWE PAUL A ,  PECCHI SABINA ,  MACHAJEWSKI TIMOTHY D ,  SHAFER CYNTHIA M ,  TAYLOR CLARKE ,  MCCREA WILLIAM R ,  MCBRIDE CHRISTOPHER ,  JAZAN ELISA ,  HEISE CARLA

IPC分类号： A61K31/47 ,  C07D487/08 ,  A61K31/19 ,  A61K31/4166 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61P9/00 ,  A61P35/00 ,  A61P43/00 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D405/14 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D453/02 ,  C07D471/04 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61K31/19 ,  A61K31/439 ,  A61K31/47 ,  A61K31/4709 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/541 ,  C07D401/04 ,  C07D401/14 ,  C07D405/04 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D453/02 ,  A61K2300/00

摘要： Organic compounds having the formulas (I) and (II) are provided where the variables have the values described herein. Medicaments include an anti-cancer drug selected from 5-FU or CPT 11 and a compound of formula (I) or formula (II), a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer in treatin along with an anti-cancer drug selected from 5-FU or CPT-11. The medicaments may be used in treating cancer. The use of a compound of formula (I) or formula (II), a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer in treating cancer in conjunction with an anti-cancer drug selected from 5-FU or CPT-11 is also provided.

公开(公告)号：EP1539754A4

公开(公告)日：2009-02-25

申请号：EP03781286

申请日：2003-08-19

申请人： NOVARTIS VACCINES & DIAGNOSTIC

发明人： BARSANTI PAUL A ,  BUSSIERE DIRKSEN ,  HARRISON STEPHEN D ,  HEISE CARLA C ,  JANSEN JOHANNA M ,  JAZAN ELISA ,  MACHAJEWSKI TIMOTHY D ,  MCBRIDE CHRISTOPHER ,  MCCREA WILLIAM R ,  NG SIMON ,  NI ZHI-JIE ,  PECCHI SABINA ,  PFISTER KEITH ,  RAMURTHY SAVITHRI ,  RENHOWE PAUL A ,  SHAFER CYNTHIA M ,  SILVER JOEL B ,  WAGMAN ALLAN ,  WIESMANN MARION

IPC分类号： A61K31/4375 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/52 ,  A61P35/00 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D453/02 ,  C07D453/06 ,  C07D471/04 ,  A61K31/435

CPC分类号： C07D401/04 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/52 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14 ,  C07D453/02 ,  C07D453/06 ,  C07D471/04