公开(公告)号：EP1373529A1

公开(公告)日：2004-01-02

申请号：EP02702181.5

申请日：2002-02-25

申请人： NV reMynd

发明人： VAN LEUVEN, Freddy ,  WINDERICKX, Joris

IPC分类号： C12N15/81 ,  C12N15/12 ,  C12N1/21 ,  C12Q1/02

CPC分类号： G01N33/6896 ,  C07K14/4711 ,  C12N15/81 ,  C12Q1/025 ,  G01N2500/00 ,  G01N2800/28

摘要： The present invention relates to cell models of Alzheimer's disease. Transgenic yeast cells are described as models for the tau-opathy in Alzheimer's disease. These cell models comprise recombinant DNA constructs comprising control sequences and a cDNA sequence encoding a human tau-isoform and another similar construct comprising a protein kinase that is capable, directly or indirectly, of modulating the phosphorylation of the microtubule-associated protein tau. The transgenic cells are useful for high-throughput testing for potential therapeutic agents for Alzheimer's disease and other neurodegenerative disorders.

公开(公告)号：EP1373529B1

公开(公告)日：2008-04-23

申请号：EP02702181.5

申请日：2002-02-25

申请人： NV reMynd

发明人： VAN LEUVEN, Freddy ,  WINDERICKX, Joris

IPC分类号： C12N15/81 ,  C12N15/12 ,  C12N1/21 ,  C12Q1/02

CPC分类号： G01N33/6896 ,  C07K14/4711 ,  C12N15/81 ,  C12Q1/025 ,  G01N2500/00 ,  G01N2800/28

摘要： The present invention relates to cell models of Alzheimer's disease. Transgenic yeast cells are described as models for the tau-opathy in Alzheimer's disease. These cell models comprise recombinant DNA constructs comprising control sequences and a cDNA sequence encoding a human tau-isoform and another similar construct comprising a protein kinase that is capable, directly or indirectly, of modulating the phosphorylation of the microtubule-associated protein tau. The transgenic cells are useful for high-throughput testing for potential therapeutic agents for Alzheimer's disease and other neurodegenerative disorders.