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    METHODS FOR TREATMENT OF THIOL-CONTAINING COMPOUND DEFICIENT CONDITIONS
    4.
    发明公开
    METHODS FOR TREATMENT OF THIOL-CONTAINING COMPOUND DEFICIENT CONDITIONS 审中-公开
    用于处理含硫化合物缺陷的方法

    公开(公告)号：EP2217259A2

    公开(公告)日：2010-08-18

    申请号：EP08839204.8

    申请日：2008-10-17

    申请人： National Jewish Health

    发明人： DAY, Brian, J.

    IPC分类号： A61K38/02 ,  A61K31/711 ,  A61K31/44 ,  A61K31/352 ,  A61K31/47 ,  A61K31/12

    CPC分类号： A61K31/35 ,  A61K31/353 ,  A61K31/37 ,  A61K31/428 ,  A61K31/47 ,  A61K31/635 ,  A61K2121/00 ,  Y02A50/411 ,  Y02A50/414 ,  Y02A50/463 ,  Y02A50/471 ,  Y02A50/473 ,  Y02A50/491

    摘要： Certain embodiments in the present invention provide for methods for therapy of lung diseases and other conditions such as infection are provided. In certain embodiments, the methods comprise one or more agents capable of increasing thiol-containing compound transport via a transporter system (i.e., ABC transporters such as MDR-1 or MRP-2) in cells. Other embodiments can include the use of agents to modulate transport of thiol-containing compounds from the cell such as thiocyanate. In certain embodiments, therapeutic methods involve the administration of such agents to a patient afflicted with an inflammatory condition or infection responsive to stimulation of thiol-containing compound transport.

    摘要翻译： 本文的实施方式提供了用于治疗传染病的方法。 在某些实施方案中，方法和组合物包含一种或多种能够增加硫氰酸盐流出的试剂。 其他实施方案进一步包括用能够增加来自受试者细胞的硫氰酸盐或硫氰酸盐样化合物流出物的试剂治疗受试者的感染，由此治疗受试者中的感染。 在某些实施方案中，治疗方法涉及将此类药剂施用于患有或怀疑发生细菌，病毒，真菌或原生动物感染的受试者。