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公开(公告)号：EP3646885A1
公开(公告)日：2020-05-06
申请号：EP18825437.9
申请日：2018-06-29
发明人： TAKAHATA, Masahiko , SATO, Dai , OTA, Masahiro , SHIMIZU, Tomohiro , FUKUDA, Chie , TSUDA, Eisuke
IPC分类号： A61K39/395 , A61P19/10 , C07K16/18 , C07K16/46
摘要： An object of the present invention is to provide a pharmaceutical agent for the treatment and/or prophylaxis of pediatric osteoporosis without causing bone growth disorder in a subject to be medicated. A pharmaceutical composition for the treatment and/or prophylaxis of pediatric osteoporosis contains an antibody or a functional fragment thereof which binds to Siglec-15 and has activity of suppressing formation of osteoclasts and/or bone resorption by osteoclasts.
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公开(公告)号：EP3868757A1
公开(公告)日：2021-08-25
申请号：EP21166082.4
申请日：2015-07-06
发明人： HAGINOYA, Noriyasu , SUZUKI, Takashi , HAYAKAWA, Miho , OTA, Masahiro , TSUKADA, Tomoharu , KOBAYASHI, Katsuhiro , ANDO, Yosuke , JIMBO, Takeshi , NAKAMURA, Koichi
IPC分类号： C07D405/14 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P35/00 , A61P35/02 , A61P35/04 , A61P43/00
摘要： The present invention provides a pharmaceutical combination comprising a novel compound or a salt thereof, or crystals of the compound or the salt, and an additional antitumor agent, which inhibits Axl and is useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.
The novel compound is a pyridone derivative having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or a salt thereof, or crystals of the compound or the salt (wherein R 1 , R 2 , R 3 , R 4 , R 5 , W, X, Y, and Z are each as defined in the specification).-
公开(公告)号：EP3168219A1
公开(公告)日：2017-05-17
申请号：EP15818440.8
申请日：2015-07-06
发明人： HAGINOYA, Noriyasu , SUZUKI, Takashi , HAYAKAWA, Miho , OTA, Masahiro , TSUKADA, Tomoharu , KOBAYASHI, Katsuhiro , ANDO, Yosuke , JIMBO, Takeshi , NAKAMURA, Koichi
IPC分类号： C07D405/14 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , A61P35/00 , A61P35/02 , A61P35/04 , A61P43/00 , C07D409/14
CPC分类号： C07D409/14 , A61K31/444 , A61K31/496 , A61K31/497 , A61K31/501 , A61K31/506 , A61K31/5377 , C07B59/002 , C07B2200/05 , C07B2200/13 , C07C309/04 , C07C309/35 , C07D405/14
摘要： It is intended to provide a novel compound or a salt thereof, or crystals of the compound or the salt, which inhibit Axl and are useful in the treatment of a disease caused by hyperfunction of Axl, the treatment of a disease associated with hyperfunction of Axl, and/or the treatment of a disease involving hyperfunction of Axl.
[Solution]
The present invention provides a pyridone derivative having a tetrahydropyranylmethyl group represented by the following formula (I) having various substituents, or a salt thereof, or crystals of the compound or the salt (wherein R 1 , R 2 , R 3 , R 4 , R 5 , W, X, Y, and Z are each as defined in the specification).摘要翻译： 旨在提供抑制Ax1的新型化合物或其盐或化合物或盐的晶体，其可用于治疗由Axl功能异常引起的疾病，治疗与Axl功能异常相关的疾病 ，和/或治疗涉及Axl功能异常的疾病。 [解决方案]本发明提供具有由具有各种取代基的下式（I）表示的四氢吡喃基甲基或其盐或其化合物或其盐的结晶的吡啶酮衍生物（其中R 1，R 2，R 3， R 4，R 5，W，X，Y和Z各自如说明书中所定义）。
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公开(公告)号：EP2402349A1
公开(公告)日：2012-01-04
申请号：EP10746224.4
申请日：2010-02-24
发明人： OKAYAMA, Tooru , IKEDA, Masahiro , OHKI, Hitoshi , OTA, Masahiro , SHIBATA, Yoshihiro , NAKANISHI, Toshiyuki , UEDA, Yasusi , SUZUKI, Nobuyuki , MATUURA, Shinji
IPC分类号： C07D495/16 , A61K31/519 , A61P9/00 , A61P25/28 , A61P35/00 , A61P37/06
CPC分类号： A61K31/519 , C07D495/16
摘要： To provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity.
The present invention provides a pyrazolopyrimidine compound represented by formula (1) having various substituents which inhibits the ATPase activity of HSP90 and which has antitumor activity, an HSP90 inhibitor comprising a compound represented by formula (1), a medicament comprising a compound represented by formula (1), an anticancer agent comprising a compound represented by formula (1), a pharmaceutical composition comprising a compound represented by formula (1), and a method for treating cancer using a compound represented by formula (1).摘要翻译： 提供一种抑制HSP90作用的新化合物，特别是抑制作为伴侣蛋白的HSP90功能的新化合物，具有抗肿瘤活性。 本发明提供具有抑制HSP90的ATP酶活性的各种取代基并具有抗肿瘤活性的由式（1）表示的吡唑并嘧啶化合物，包含由式（1）表示的化合物的HSP90抑制剂，包含由式 （1）所示的化合物的抗癌剂，含有式（1）所示的化合物的抗癌剂，含有式（1）所示的化合物的药物组合物以及使用式（1）所示的化合物治疗癌症的方法。
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公开(公告)号：EP2810937A1
公开(公告)日：2014-12-10
申请号：EP13743985.7
申请日：2013-01-30
发明人： OHKI, Hitoshi , OTA, Masahiro , TAKEUCHI, Kosuke , WATANABE, Hideaki , YAMAGUCHI, Akitake , SHIBATA, Yoshihiro , TOMINAGA, Yuichi , JIMBO, Takeshi , KOBAYASHI, Keijiro , KOBAYASHI, Katsuhiro , FUKATSU, Daisuke
IPC分类号： C07D213/82 , A61K31/444 , A61K31/4545 , A61K31/501 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/08
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D451/02
摘要： Novel compounds or salts thereof, or crystals thereof, are provided which inhibit Axl and are useful for treating diseases caused by Axl hyperfunction, diseases associated with Axl hyperfunction and/or diseases accompanied by Axl hyperfunction. Pyridone derivatives represented by formula (1) having various substituents or salts thereof, or crystals thereof (where R 1 , R 2 , R 3 , R 5 , R 6 , A, W, X and n in the formula (1) are as defined in the specification, respectively) are provided.
摘要翻译： 提供新的化合物或其盐或其结晶，其抑制Ax1并且可用于治疗由Axl功能障碍引起的疾病，与Axl功能障碍相关的疾病和/或伴有Axl功能障碍的疾病。 式（1）表示的具有各种取代基或其盐的吡啶酮衍生物或其结晶（式（1）中的R 1，R 2，R 3，R 5，R 6，A，W，X和n） 分别在规范中定义）。
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公开(公告)号：EP2810937B1
公开(公告)日：2016-11-30
申请号：EP13743985.7
申请日：2013-01-30
发明人： OHKI, Hitoshi , OTA, Masahiro , TAKEUCHI, Kosuke , WATANABE, Hideaki , YAMAGUCHI, Akitake , SHIBATA, Yoshihiro , TOMINAGA, Yuichi , JIMBO, Takeshi , KOBAYASHI, Keijiro , KOBAYASHI, Katsuhiro , FUKATSU, Daisuke
IPC分类号： C07D213/82 , A61K31/444 , A61K31/4545 , A61K31/501 , A61K31/5377 , A61P35/00 , A61P43/00 , C07D401/14 , C07D405/14 , C07D413/14 , C07D471/08 , C07D401/12 , C07D451/02
CPC分类号： C07D213/82 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D451/02
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公开(公告)号：EP2402349B1
公开(公告)日：2016-04-06
申请号：EP10746224.4
申请日：2010-02-24
发明人： OKAYAMA, Tooru , IKEDA, Masahiro , OHKI, Hitoshi , OTA, Masahiro , SHIBATA, Yoshihiro , NAKANISHI, Toshiyuki , UEDA, Yasusi , SUZUKI, Nobuyuki , MATUURA, Shinji
IPC分类号： C07D495/16 , A61K31/519 , A61P9/00 , A61P25/28 , A61P35/00 , A61P37/06
CPC分类号： A61K31/519 , C07D495/16
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