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    BROWN/BEIGE ADIPOCYTE ACTIVATING AGENT CONTAINING D-ALLULOSE AS ACTIVE INGREDIENT
    1.
    发明公开
    BROWN/BEIGE ADIPOCYTE ACTIVATING AGENT CONTAINING D-ALLULOSE AS ACTIVE INGREDIENT 审中-公开

    公开(公告)号：EP3878457A1

    公开(公告)日：2021-09-15

    申请号：EP19881272.9

    申请日：2019-11-07

    申请人： National University Corporation Kagawa University

    发明人： MURAO, Koji ,  IMACHI, Hitomi ,  IZUMORI, Ken ,  YOSHIHARA, Akihide

    IPC分类号： A61K31/7004 ,  A23L33/125 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P43/00

    摘要： To provide a brown and beige adipocyte activating agent and a brown and beige adipocyte activating food, each containing D-allulose as an active ingredient. Provided are a brown and beige adipocyte activating agent containing D-allulose as an active ingredient; a brown and beige adipocyte activating agent containing at least D-allulose and having a UCP-1 expression promoting action; a brown and beige adipocyte activating agent which enhances UCP-1 expression and thereby activates brown and beige adipocytes; an energy consumption promoting agent containing D-allulose as an active ingredient; an energy consumption promoting agent which activates brown and beige adipocytes and thereby promotes energy consumption; a UCP-1 expression enhancing agent containing D-allulose as an active ingredient; and a composition or food composition containing these agents.

    METHOD FOR MASS-PRODUCING SWEETENER HAVING FLAVOR QUALITY SIMILAR TO THAT OF SUGAR AND HAVING D-ALLULOSE FUNCTIONALITY
    6.
    发明公开
    METHOD FOR MASS-PRODUCING SWEETENER HAVING FLAVOR QUALITY SIMILAR TO THAT OF SUGAR AND HAVING D-ALLULOSE FUNCTIONALITY 审中-实审

    公开(公告)号：EP4338598A1

    公开(公告)日：2024-03-20

    申请号：EP21939592.8

    申请日：2021-05-07

    申请人： National University Corporation Kagawa University

    发明人： AKIMITSU, Kazuya ,  IZUMORI, Ken ,  YOSHIHARA, Akihide ,  TAKAOKA, Seizo ,  KATO, Shiro ,  MOCHIZUKI, Susumu

    IPC分类号： A23L27/00 ,  A23L27/30 ,  A23L33/10

    摘要： Object is to mass-produce a sweetener containing D-allulose and having a sweetness degree and taste quality very close to those of sugar at a world scale and at a low cost with price competitiveness. Provided is a mass-production method of a sweetener having functionality of D-allulose and a taste quality close to that of sugar, including acting D-allulose 3-epimerase on a D-glucose- and D-fructose-containing inexpensive composition used as a raw material, allowing isomerization of D-fructose in the raw material to proceed by an isomerization reaction between D-fructose and rare sugar D-allulose, terminating the reaction at the stage when a rare sugar D-allulose content reaches an intended content of an intended product, and thus obtaining an intended product composed of rare sugar D-allulose, D-glucose, and D-fructose, in which the D-fructose content is in a range that compensates for a weak point of D-allulose in sweetness degree and gives a taste quality close to that of sugar in cooperation with D-allulose and D-glucose.

    NOVEL L-RHAMNOSE ISOMERASE
    7.
    发明公开
    NOVEL L-RHAMNOSE ISOMERASE 审中-公开

    公开(公告)号：EP4130278A1

    公开(公告)日：2023-02-08

    申请号：EP21773444.1

    申请日：2021-03-26

    申请人： National University Corporation Kagawa University

    发明人： AKIMITSU, Kazuya ,  IZUMORI, Ken ,  YOSHIHARA, Akihide ,  KATO, Shiro ,  MOCHIZUKI, Susumu ,  YOSHIDA, Hiromi ,  KAMITORI, Shigehiro

    IPC分类号： C12N15/61 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/90 ,  C12N11/082 ,  C12N15/63 ,  C12P19/24

    摘要： A highly safe, highly active, and heat-resistant L-rhamnose isomerase and an amino acid-substituted mutant thereof, a microorganism producing them, or a method for producing an aldose or a ketose are provided, all of which are capable of being used in the food industry.
    L-Rhamnose isomerase, which is capable of being obtained from a microorganism belonging to the genus Erwinia, has a 48 kDa subunit molecular mass measured by SDS-PAGE, and has the following substrate specificities (A) and (B).
    (A) An isomerase activity of recognizing and reacting with a CHO group of C1 and an OH group of C2 of an aldose to convert the CHO group of C1 to an OH group and the OH group of C2 to a CO group, alternatively, recognizing and reacting with an OH group of C1 and a CO group of C2 of a ketose to convert the OH group of C1 to a CHO group and the CO group of C2 to an OH group.
    (B) An activity of catalyzing an isomerization reaction between L-rhamnose and L-rhamnulose, between L-lyxose and L-xylulose, between L-mannose and L-fructose, between D-ribose and D-ribulose, between L-talose and L-tagatose, and between D-allose and D-allulose.