公开(公告)号：EP3257868A1

公开(公告)日：2017-12-20

申请号：EP16749338.6

申请日：2016-02-12

申请人： National University Corporation Kyoto Institute of Technology ,  Nissan Chemical Industries, Ltd.

发明人： KUMADA, Yoichi ,  OTSUKI, Ryoko ,  AKAI, Ryota ,  KATAYAMA, Junko ,  MATOBA, Kazutaka

IPC分类号： C07K17/08 ,  C07K14/00 ,  C12N7/08 ,  C12N9/00 ,  C12N15/00

CPC分类号： C07K17/08 ,  C07K14/00 ,  C08G77/04 ,  C12N7/08 ,  C12N9/00 ,  C12N15/00 ,  C12N15/63

摘要： An object of the present invention is to provide a polydimethylsiloxane substrate to which a peptide having an affinity for polydimethylsiloxane (PDMS) is bound; a method for immobilizing a target protein on a polydimethylsiloxane substrate; a peptide having an affinity for PDMS; a polynucleotide encoding a peptide having an affinity for PDMS; and a vector using thereof. A polydimethylsiloxane substrate to which a peptide having an affinity for polydimethylsiloxane is bound, the peptide comprising the following peptide (1a) or (1b), or a fragment thereof: (1a) a peptide comprising an amino acid sequence represented by at least one member selected from the group consisting of SEQ ID NOs: 1 to 9; and (1b) a peptide comprising the amino acid sequence of (1a) in which one or more amino acids are deleted, substituted, and/or added, the peptide having an affinity for polydimethylsiloxane.

摘要翻译： 本发明的目的在于提供与聚二甲基硅氧烷（PDMS）具有亲和性的肽结合的聚二甲基硅氧烷基材， 将目标蛋白质固定在聚二甲基硅氧烷基底上的方法; 对PDMS具有亲和性的肽; 编码对PDMS具有亲和力的肽的多核苷酸; 以及使用它的载体。 （1a）或（1b）的肽，或其片段：（1a）包含由至少一个成员表示的氨基酸序列的肽，其中所述肽具有与聚二甲基硅氧烷的亲和性的肽结合到所述聚二甲基硅氧烷底物上， 选自由SEQ ID NO：1至9组成的组; 和（1b）包含其中一个或多个氨基酸被缺失，取代和/或添加的（1a）的氨基酸序列的肽，所述肽对聚二甲基硅氧烷具有亲和性。

公开(公告)号：EP3363870A1

公开(公告)日：2018-08-22

申请号：EP16855532.4

申请日：2016-10-14

申请人： Nissan Chemical Industries, Ltd.

发明人： KATAYAMA, Junko ,  HIROI, Yoshiomi ,  AIHARA, Ayako ,  ABE, Natsuki ,  NISHINO, Taito

IPC分类号： C09D201/06 ,  A61K35/19 ,  B01J19/00 ,  C08F220/34 ,  C08F230/02 ,  C09D5/16 ,  C09D143/02 ,  C12M1/00 ,  C12M1/26 ,  G01N37/00

CPC分类号： C12M23/20 ,  A61K35/19 ,  B01J19/00 ,  C08F220/34 ,  C08F230/02 ,  C09D5/16 ,  C09D143/02 ,  C09D201/06 ,  C12M1/00 ,  C12M1/26 ,  C12M23/16 ,  G01N37/00

摘要： This is to provide a coating agent for a flow passage which is capable of being coated on the inner surface of the flow passage with an extremely simple and easy operation and having an excellent ability to inhibit adhesion of a biological substance, and a flow passage device having the coating agent for a flow passage on at least part of an inner surface of a flow passage, a platelet-producing flow passage device and a method for manufacturing the same.
Provided are a coating agent for a flow passage which comprises a copolymer containing a recurring unit which contains an organic group of the following formula (a) and a recurring unit which contains an organic group of the following formula (b), and a flow passage device having the coating agent for a flow passage on at least part of an inner surface of a flow passage, a platelet-producing flow passage device and a method for manufacturing the same.


wherein U a1 , U a2 , U b1 , U b2 , U b3 and An - are as defined in the present specification and the claims.