公开(公告)号：EP2637694A1

公开(公告)日：2013-09-18

申请号：EP11840401.1

申请日：2011-11-11

申请人： Nektar Therapeutics

发明人： BOSSARD, Mary J. ,  ALI, Cherie F. ,  LIU, Xiaofeng ,  CHARYCH, Deborah H. ,  ZAPPE, Harold ,  WANG, Yujun ,  HUANG, Jicai

IPC分类号： A61K45/00 ,  C07K1/00

CPC分类号： A61K47/60 ,  A61K38/2013 ,  C07K14/55

摘要： Conjugates of an interleukin-2 (“IL-2”) moiety and one or more nonpeptidic, water-soluble polymers are provided. Typically, the nonpeptidic, water-soluble polymer is poly(ethylene glycol) or a derivative thereof. Also provided, among other things, are compositions comprising conjugates, methods of making conjugates, methods of administering compositions to an individual, nucleic acid sequences, expression systems, host cells, and methods for preparing IL-moieties.

公开(公告)号：EP2334336A1

公开(公告)日：2011-06-22

申请号：EP09789332.5

申请日：2009-09-17

申请人： Nektar Therapeutics

发明人： ROCZNIAK, Steven O. ,  ALI, Cherie F.

IPC分类号： A61K47/48 ,  C07K14/575

CPC分类号： A61K47/60

摘要： The invention provides osteocalcin that is chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

公开(公告)号：EP2340050A2

公开(公告)日：2011-07-06

申请号：EP09740204.4

申请日：2009-09-17

申请人： Nektar Therapeutics

发明人： ALI, Cherie F. ,  FRY, Dennis G. ,  BOSSARD, Mary J. ,  ROCZNIAK, Steven O.

IPC分类号： A61K47/48 ,  C07K14/61

CPC分类号： C07K14/61 ,  A61K47/60

摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.

公开(公告)号：EP2337585A1

公开(公告)日：2011-06-29

申请号：EP09740206.9

申请日：2009-09-17

申请人： Nektar Therapeutics

发明人： BOSSARD, Mary ,J. ,  ROCZNIAK, Steven O. ,  ALI, Cherie F.

IPC分类号： A61K47/48 ,  C07K14/605

CPC分类号： C07K14/605 ,  A61K47/60

摘要： The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water soluble oligomer.