公开(公告)号：EP3517541A1

公开(公告)日：2019-07-31

申请号：EP19156409.5

申请日：2013-05-06

申请人： Nicox Ophthalmics, Inc.

发明人： CAVANAGH, Thomas ,  BARMAN, Shikha P. ,  HAO, Tian ,  LELAND, Thomas B. ,  THEKKEDATH, Ritesh V.

IPC分类号： C07J31/00 ,  C07J71/00 ,  A61K31/58 ,  A61P5/44

摘要： The present invention provided nanocrystals of fluticasone propionate having an X-ray powder diffraction pattern including peaks at about 7.8, 15.7, 20.8, 23.7, 24.5, and 32.5 degrees 2θ further including peaks at about 9.9, 13.0, 14.6, 16.0, 16.9, 18.1, and 34.3 degrees 2θ, characterized in that :the nanocrystals are nanoplates having the [001] crystallographic axis substantially normal to the surfaces that define the thickness of the nanoplates,wherein said nanoplates have an average size between 100 and 1000 nm.

公开(公告)号：EP3741772A1

公开(公告)日：2020-11-25

申请号：EP20177447.8

申请日：2013-05-06

申请人： Nicox Ophthalmics, Inc.

发明人： CAVANAGH, Thomas ,  BARMAN, Shikha P. ,  HAO, Tian ,  LELAND, Thomas B. ,  THEKKEDATH, Ritesh V.

IPC分类号： C07J31/00 ,  C07J71/00 ,  A61K31/58 ,  A61P5/44 ,  A61P11/00 ,  A61P11/06 ,  A61P27/02 ,  A61P27/04 ,  A61P27/14 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00

摘要： The present invention further provides method of preparing nanocrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).

公开(公告)号：EP3517541B1

公开(公告)日：2020-07-15

申请号：EP19156409.5

申请日：2013-05-06

申请人： Nicox Ophthalmics, Inc.

发明人： CAVANAGH, Thomas ,  BARMAN, Shikha P. ,  HAO, Tian ,  LELAND, Thomas B. ,  THEKKEDATH, Ritesh V.

IPC分类号： C07J31/00 ,  C07J71/00 ,  A61K31/58 ,  A61P5/44

公开(公告)号：EP2847207B1

公开(公告)日：2019-03-27

申请号：EP13787795.7

申请日：2013-05-06

申请人： Nicox Ophthalmics, Inc.

发明人： CAVANAGH, Thomas ,  BARMAN, Shikha, P. ,  HAO, Tian ,  LELAND, Thomas, B. ,  THEKKEDATH, Ritesh, V.

IPC分类号： C07J31/00 ,  C07J71/00

公开(公告)号：EP2941437B1

公开(公告)日：2018-09-05

申请号：EP13870129.7

申请日：2013-11-13

申请人： Nicox Ophthalmics, Inc.

发明人： BARMAN, Shikha, P. ,  THEKKEDATH, Ritesh, Vasudevan ,  BARMAN, Koushik ,  CAVANAGH, Thomas ,  HAO, Tian ,  LELAND, Thomas, Bovard

IPC分类号： C07J71/00 ,  A61K31/58 ,  A61P5/44

CPC分类号： C07J71/0031 ,  C07B2200/13 ,  C07J31/006

摘要： The present invention further provides method of preparing nanocrystals or microcrystals of a hydrophobic therapeutic agent such as fluticasone or triamcinolone, pharmaceutical compositions (e.g., topical or intranasal compositions) thereof and methods for treating and/or preventing the signs and/or symptoms of disorders such as blepharitis, meibomian gland dysfunction or skin inflammation or a respiratory disease (e.g., asthma).