公开(公告)号：EP4201945A1

公开(公告)日：2023-06-28

申请号：EP22820140.6

申请日：2022-06-02

申请人： Nippon Fine Chemical Co., Ltd.

发明人： TOMITA, Koji ,  INOUE, Yuki ,  YOKOUCHI, Ayano ,  ASAYAMA, Sae ,  FUKATA, Naofumi

IPC分类号： C07F9/10 ,  A61K9/16 ,  A61K31/7088 ,  A61K31/713 ,  A61K45/00 ,  A61K47/24 ,  A61K47/28 ,  A61K48/00 ,  C07F9/6509

摘要： The present invention provides a charge-reversible phospholipid that is not positively charged at a pH of the body fluid (typically in the neutral range) and has low cytotoxicity.
The present invention provides a phospholipid represented by formula (1):

wherein m represents a natural number of 9 to 25, n represents a natural number of 10 to 15, X 1 , X 2 , and X 3 are the same or different and each represent H or OH, and R 1 represents the following formula (i) or (ii):
wherein p represents 1 or 2, q represents 1 or 2, and r represents an integer of 1 to 4; or
wherein s represents an integer of 1 to 3, and R 2 represents a hydrogen atom or a hydrocarbon group.