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1.发明授权LANOLIN FATTY ACIDS, SEPARATION THEREOF, AND COSMETIC AND EXTERNAL PREPARATION 失效羊毛脂脂肪酸，它们的分离和cosmetic-和外用制剂
公开(公告)号：EP0596135B1
公开(公告)日：1997-08-13
申请号：EP93909422.3
申请日：1993-04-26
发明人： MIYAZAKI, Katsuhiko , KAWASAKI, Toshiyuki , KATO, Isao , NODA, Kenji , OSAKI, Masakatsu , NAYESHIRO, Hidekazu , ANDO, Hideya
CPC分类号： C11C3/00 , A61K8/361 , A61K8/925 , A61Q5/02 , A61Q5/12 , A61Q19/00 , C07C53/126 , C07C59/01 , C11B11/005 , C11C1/005 , C11C1/103
摘要： A process for producing α- and φ-hydroxy fatty acids by treating lanolin fatty acids with boric acid to esterify hydroxy fatty acids contained therein, distilling the reaction product in a vacuum to separate and purify the borates of the hydroxy fatty acids and non-hydroxy fatty acids, hydrolyzing the purified borates, and distilling the hydrolyzate; each of the lanolin fatty acids and esters thereof thus obtained; and cosmetics and external preparations prepared therefrom. The invention process provides light-colored, nearly odorless lanolin fatty acids readily and efficiently on an industrial scale, and the obtained acids can be utilized in the fields of medicines and cosmetics.
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公开(公告)号：EP0685488A1
公开(公告)日：1995-12-06
申请号：EP94903009.2
申请日：1993-12-16
CPC分类号： C07J9/00
摘要： A process for producing high-quality cholesterol by selectively reducing impurities contained in crude cholesterol, mainly desmosterol, into cholesterol. The process can provide high-purity cholesterol containing at most 0.3 % of desmosterol and at most 0.5 % of dihydrocholesterol and having a purity of at least 99 % after reduction and crystallization in a yield of 85 % or above.
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3.发明授权
公开(公告)号：EP0394496B1
公开(公告)日：1995-08-23
申请号：EP89911861.6
申请日：1989-10-25
发明人： KITAZAWA, Sadaya Yanagi-mansion 506 , OKUMURA, Masakazu 119-112, Noguchi , KOJIMA, Masaki , KINOMURA, Keisuke Higashikakogawa-haitaun A-703 , SAKAKIBARA, Toshiyuki Maikodai-green-mansion 220
CPC分类号： C07H15/10 , A61L33/064 , C07H15/08 , C08F20/28 , C08F20/30 , C08F290/10 , C08F299/024 , C08J7/047 , C08J2369/00 , C08J2433/00 , G02B1/041 , Y02P20/55 , C08L33/14
摘要： The invention provides glycoside derivatives represented by general formula (I) (wherein G-O- represents a sugar residue free of the protective group, r represents hydrogen or methyl, m represents 1 or 2, n represents an integer of 1 to 4, and l represents an integer of 1 or more provided that l « n), polymers containing said glycoside derivatives, a process for their preparation, and uses of said polymers.
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公开(公告)号：EP0263027B1
公开(公告)日：1990-11-14
申请号：EP87402167.8
申请日：1987-09-29
IPC分类号： B01J27/188 , B01J27/198 , B01J23/22 , B01J23/24 , C07H15/04 , C07H15/14 , B01J23/16
CPC分类号： C07H15/18 , B01J23/16 , B01J27/188 , B01J27/198 , C07H15/04
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公开(公告)号：EP4306531A1
公开(公告)日：2024-01-17
申请号：EP22766926.4
申请日：2022-03-01
发明人： TOMITA, Koji , INOUE, Yuki , YOKOUCHI, Ayano , FUKATA, Naofumi , MAEDA, Noriyuki
IPC分类号： C07F9/6509 , A61K9/14 , A61K31/7088 , A61K31/713 , A61K47/24 , A61K47/28 , A61K48/00
摘要： Provided is a charge-reversible and ethanol-soluble phospholipid suitable for the preparation of lipid particles. A phospholipid represented by formula (1):
wherein R 1 and R 2 are the same or different and each represent a chain hydrocarbon group, R 3 represents a hydrogen atom or a hydrocarbon group, and m represents an integer of 1 to 3.-
公开(公告)号：EP4201945A1
公开(公告)日：2023-06-28
申请号：EP22820140.6
申请日：2022-06-02
发明人： TOMITA, Koji , INOUE, Yuki , YOKOUCHI, Ayano , ASAYAMA, Sae , FUKATA, Naofumi
IPC分类号： C07F9/10 , A61K9/16 , A61K31/7088 , A61K31/713 , A61K45/00 , A61K47/24 , A61K47/28 , A61K48/00 , C07F9/6509
摘要： The present invention provides a charge-reversible phospholipid that is not positively charged at a pH of the body fluid (typically in the neutral range) and has low cytotoxicity.
The present invention provides a phospholipid represented by formula (1):
wherein m represents a natural number of 9 to 25, n represents a natural number of 10 to 15, X 1 , X 2 , and X 3 are the same or different and each represent H or OH, and R 1 represents the following formula (i) or (ii):
wherein p represents 1 or 2, q represents 1 or 2, and r represents an integer of 1 to 4; or
wherein s represents an integer of 1 to 3, and R 2 represents a hydrogen atom or a hydrocarbon group.-
7.发明公开METHOD OF MEASURING CONTENT OF POLYCYCLIC AROMATIC COMPOUND IN LANOLIN AND REMOVAL THEREOF 失效MESSVERFAHREN DES GEHALTS POLYAROMATISCHER VERBINDUNGEN在LANOLIN UND IHRE ENTFERNUNG。
公开(公告)号：EP0632267A1
公开(公告)日：1995-01-04
申请号：EP94904003.4
申请日：1994-01-07
CPC分类号： C11B11/005 , G01N30/02 , G01N30/461 , G01N30/74 , G01N2030/027 , B01D15/34 , G01N21/64
摘要： The invention provides a method of measuring the content of polycyclic aromatic compounds (PAH) remaining in lanolin, which comprises separating and concentrating the PAH by gel permeation chromatography using a styrene-divinylbenzene copolymer and determining the concentrated PAH by HPLC with a fluorometric detector; a method of removing the remaining PAH, which comprises measuring the PAH removal activity of active carbon by the above measuring method to thereby select the optimum adsorption condition and calculate the amount of the active carbon required for lowering the PAH content, and mixing the required amount of active carbon with lanolin to thereby effect specific adsorption of the PAH onto the active carbon; and a method of removing the PAH remaining in wool grease or lanolin by the vacuum distillation of the grease or lanolin under specified conditions either directly or after being treated with a borate and, if necessary, obtaining various lanolin derivatives from the treated wool grease or lanolin.
摘要翻译： 本发明提供一种测定羊毛脂中残留的多环芳香化合物（PAH）含量的方法，其中包括使用苯乙烯 - 二乙烯基苯共聚物通过凝胶渗透色谱法分离和浓缩PAH，并用荧光检测器通过HPLC测定浓缩的PAH; 一种除去剩余的PAH的方法，其包括通过上述测量方法测量活性炭的PAH去除活性，从而选择最佳吸附条件并计算降低PAH含量所需的活性炭的量，并将所需量 的活性炭与羊毛脂结合，从而实现PAH对活性炭的特异性吸附; 以及通过在特定条件下直接或在用硼酸盐处理之后真空蒸馏润滑脂或羊毛脂以除去在羊毛脂或羊毛脂中残留的PAH的方法，并且如果需要，从经处理的羊毛脂或羊毛脂获得各种羊毛脂衍生物 。
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8.发明公开GLYCOSIDE DERIVATIVES, POLYMERS CONTAINING GLYCOSIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND USE OF SAID POLYMERS 失效GLYKOSID-DERIVATE，POLYMERE ENTHALTEND GLYKOSID-DERIVATE，VERFAHREN ZUR HERSTELLUNG UND DEREN VERWENDUNG。
公开(公告)号：EP0394496A1
公开(公告)日：1990-10-31
申请号：EP89911861.6
申请日：1989-10-25
发明人： KITAZAWA, Sadaya Yanagi-mansion 506 , OKUMURA, Masakazu 119-112, Noguchi , KOJIMA, Masaki , KINOMURA, Keisuke Higashikakogawa-haitaun A-703 , SAKAKIBARA, Toshiyuki Maikodai-green-mansion 220
CPC分类号： C07H15/10 , A61L33/064 , C07H15/08 , C08F20/28 , C08F20/30 , C08F290/10 , C08F299/024 , C08J7/047 , C08J2369/00 , C08J2433/00 , G02B1/041 , Y02P20/55 , C08L33/14
摘要： The invention provides glycoside derivatives represented by general formula (I) (wherein G-O- represents a sugar residue free of the protective group, r represents hydrogen or methyl, m represents 1 or 2, n represents an integer of 1 to 4, and I represents an integer of 1 or more provided that 1 ≤ n), polymers containing said glycoside derivatives, a process for their preparation, and uses of said polymers.
摘要翻译： 糖苷衍生物。 的式（I），它们的均聚物和共聚物是新的：其中G-O-是不含保护性gps的糖残基; R为H或Me; m为1或2; n为1-4; p至少为1; p小于或等于n。 （I）的聚合物含有式（II）的糖苷单元：并且还可以含有共聚单元例如。 烯烃单元， 其中R 2 -R 4是H或Me; R5是-COOR6，-CON（R7）2，-CN，-OH，-OCOR8，苯基（选自一个或多个Cl，低级烷基，氰基，氨基，OH或低级烷氧基gps），吡啶基 低级烷基），2-氧代吡咯基（选自烷基）或咔唑基; R6是H，烷基，羟基，环，氨基或二烷基氨基烷基，缩水甘油基，四氢呋喃基，苄基或-CH2CH2O）aCH2CH2OH（a = 1-10）; R7是H或低级烷基（两个R7可以相同或不同）; R8是低级烷基。 在共聚物中，（II）的比例可以为1-99％摩尔，（III）为99-1％摩尔。
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公开(公告)号：EP0195311B1
公开(公告)日：1990-06-27
申请号：EP86102861.1
申请日：1986-03-05
CPC分类号： C12P7/6436 , C07J9/00 , C11C3/003 , C11C3/04 , C12P1/00 , C12P7/6454
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10.发明公开Method for preparing lipid powder for use in preparing liposomes and method for preparing liposomes 失效一种用于制备脂质体和用于制备脂质体的方法制备脂质粉剂使用方法。
公开(公告)号：EP0357005A1
公开(公告)日：1990-03-07
申请号：EP89115945.1
申请日：1989-08-29
IPC分类号： A61K9/127
CPC分类号： A61K9/1277 , Y10S159/10
摘要： The present invention provides
(1) a method for preparing lipid powder for use in the preparing liposome, which comprises supplying at a constant speed an organic solvent solution of lipids having liposome membrane forming ablility to a tubular heater heated externally, evaporating the organic solvent in the heater to prepare a mixture substantially of solids and organic solvent vapor and introducing this mixture at a high speed into a vacuum chamber of not more than 300 mm Hg, to volatilize the organic solvent instantaneously and dry the solids, and
(2) a method for preapring liposomes comprising dispersing the lipid powder obtained by the above method (1) into an aqueous solvent.摘要翻译： 本发明提供了（1）用于制备脂质粉末在制备脂质体的方法，包括在具有脂质体膜形成ablility从外部加热的管式加热器的脂质的有机溶剂溶液的恒定速度供给使用，蒸发有机溶剂的方法 加热器，以制备基本上由固体颗粒和有机溶剂蒸汽的混合物以高速此混合物引入不超过300毫米汞柱的真空室中，以瞬时地使有机溶剂挥发和干燥固体，和（2）的方法 用于脂质体preapring包括wässrige溶剂通过上述方法（1）中获得到脂质粉末分散。 升
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