公开(公告)号：EP4306531A1

公开(公告)日：2024-01-17

申请号：EP22766926.4

申请日：2022-03-01

申请人： Nippon Fine Chemical Co., Ltd.

发明人： TOMITA, Koji ,  INOUE, Yuki ,  YOKOUCHI, Ayano ,  FUKATA, Naofumi ,  MAEDA, Noriyuki

IPC分类号： C07F9/6509 ,  A61K9/14 ,  A61K31/7088 ,  A61K31/713 ,  A61K47/24 ,  A61K47/28 ,  A61K48/00

摘要： Provided is a charge-reversible and ethanol-soluble phospholipid suitable for the preparation of lipid particles. A phospholipid represented by formula (1):

wherein R 1 and R 2 are the same or different and each represent a chain hydrocarbon group, R 3 represents a hydrogen atom or a hydrocarbon group, and m represents an integer of 1 to 3.

公开(公告)号：EP4201945A1

公开(公告)日：2023-06-28

申请号：EP22820140.6

申请日：2022-06-02

申请人： Nippon Fine Chemical Co., Ltd.

发明人： TOMITA, Koji ,  INOUE, Yuki ,  YOKOUCHI, Ayano ,  ASAYAMA, Sae ,  FUKATA, Naofumi

IPC分类号： C07F9/10 ,  A61K9/16 ,  A61K31/7088 ,  A61K31/713 ,  A61K45/00 ,  A61K47/24 ,  A61K47/28 ,  A61K48/00 ,  C07F9/6509

摘要： The present invention provides a charge-reversible phospholipid that is not positively charged at a pH of the body fluid (typically in the neutral range) and has low cytotoxicity.
The present invention provides a phospholipid represented by formula (1):

wherein m represents a natural number of 9 to 25, n represents a natural number of 10 to 15, X 1 , X 2 , and X 3 are the same or different and each represent H or OH, and R 1 represents the following formula (i) or (ii):
wherein p represents 1 or 2, q represents 1 or 2, and r represents an integer of 1 to 4; or
wherein s represents an integer of 1 to 3, and R 2 represents a hydrogen atom or a hydrocarbon group.

公开(公告)号：EP3611178A1

公开(公告)日：2020-02-19

申请号：EP18784209.1

申请日：2018-03-01

申请人： Nippon Fine Chemical Co., Ltd. ,  Shizuoka Prefectural University Corporation

发明人： ASAI, Tomohiro ,  OKU, Naoto ,  MAEDA, Noriyuki ,  FUKATA, Naofumi ,  TOMITA, Koji

IPC分类号： C07F9/10 ,  A61K9/16 ,  A61K31/7088 ,  A61K47/10 ,  A61K47/24 ,  A61K47/28 ,  A61K48/00 ,  A61P43/00

摘要： An object is to provide a lipid particle that is not positively charged at a pH of the body fluid (typically in the neutral range), and that enables efficient onset of the effect of a medicinal substance encapsulated in the lipid particle; and to provide a lipid for forming the lipid particle. The object is achieved by the phospholipid represented by formula (1), and a lipid particle containing the phospholipid:

wherein R 1 and R 2 are identical or different, and represent a chain hydrocarbon group, m represents 1 or 2, n represents 1 or 2, and p represents an integer of 1 to 4.