公开(公告)号：EP0468352A2

公开(公告)日：1992-01-29

申请号：EP91111925.3

申请日：1991-07-17

申请人： Nippon Kayaku Kabushiki Kaisha

发明人： Ichikawa, Yuh-ichiro ,  Akaba, Hiroshi ,  Sugawara, Yuka ,  Shiozawa, Akira ,  Matsubara, Kenichi ,  Nagahata, Takemitsu ,  Hoshino, Hiroo ,  Seki, Jun-ichi

IPC分类号： C07D473/34 ,  C07D473/18 ,  A61K31/52

CPC分类号： C07D239/54 ,  C07D473/00

摘要： A novel nucleic acid derivative represented by the following general formula (I) and physiologically acceptable salt thereof which are expected to have an antiviral activity:
wherein B represents a nucleic acid base derivative; A 1 and A 2 represent, independently of each other, OR 1 or OCOR 1 ; R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group; ℓ represents a number of 0 or 1; and m and n each represents an integer of 0-2; provided that when ℓ and m are 0, n is 0 or 2.

摘要翻译： 预期具有抗病毒活性的由以下通式（I）表示的新型核酸衍生物及其生理学上可接受的盐：其中B表示核酸碱基衍生物; A 1和A 2彼此独立地表示OR 1或OCOR 1; R 1表示氢原子，取代或未取代的烷基或取代或未取代的芳基; l表示0或1的数; m和n分别表示0〜2的整数。 条件是当l和m为0时，n为0或2。

公开(公告)号：EP0334250A2

公开(公告)日：1989-09-27

申请号：EP89104910.8

申请日：1989-03-18

申请人： Nippon Kayaku Kabushiki Kaisha

发明人： Saito, Seiichi ,  Hasegawa, Shigeru ,  Takahashi, Katsutoshi ,  Shimada, Nobuyoshi ,  Seki, Jun-ichi ,  Hoshino, Hiroo ,  Nishiyama, Yukihiro 8-25, Shiratori-2-chome ,  Matsubara, Kenichi ,  Nagahata, Takemitsu Senri Sakanoki Haitsu 208

IPC分类号： C07H19/16 ,  C07D473/00 ,  A61K31/52 ,  A61K31/70 ,  C12P19/40

CPC分类号： C07H19/02 ,  C07D305/06 ,  C07D305/08 ,  C07D305/10

摘要： This invention relates to oxetanocin-related compounds represented by the following formula (I):
[in formula (I), R 1 , Y and B have the following meanings:

(a) R 1 represents -CH 2 0H or -CN 2 OCO-(alkyl),
(b) Y represents
provided that R 2 is -H, -OH or -CHzOH and R 3 is -H, -OH, halogen atom, -CH 2 OH, lower alkyl group, -CH z -N 3 , -CH 2 -F, -N 3 , -COOH, -NH 2 , -CH 2 OSO 3 H or -CH 2 OCO-(lower alkyl), and
(c) B represents a residue of purine base,
(d) provided that R 1 and R 3 cannot simultaneously represente -CH 2 OH]

and their salts which have activities such as an antiviral activity and the like and are expectedly useful as a pharmaceutical and the like.

摘要翻译： 本发明涉及由下式（I）表示的氧杂环丁霉素相关化合物： [式（I）中，R 1，Y和B具有以下含义：（a）R 1表示-CH 2 OH或-CH 2 OOC- ），（b）Y表示，条件是R2是-H，-OH或-CH2OH，R3是-H，-OH，卤素原子，-CH2OH，低级烷基，-CH2-N3，-CH2-F ，-N3，-COOH，-NH2，-CH2OSO3H或-CH2OCO-（低级烷基），（c）B表示嘌呤碱基的残基，（d）R1和R3不能同时表示-CH2OH] 其具有抗病毒活性等活性，并且预期可用作药物等。

公开(公告)号：EP0358154B1

公开(公告)日：1998-12-02

申请号：EP89116327.1

申请日：1989-09-05

申请人： NIPPON KAYAKU KABUSHIKI KAISHA

发明人： Ichikawa, Yuh-ichiro ,  Narita, Aya ,  Matsuo, Kaoru ,  Aoyama, Keiko ,  Matsumura, Fumiko ,  Nishiyama, Yukihiro ,  Matsubara, Kenichi ,  Nagahata, Takemitsu ,  Hoshino, Hiroo ,  Seki, Jun-ichi ,  Narasaka, Koichi ,  Hayashi, Yujiro

IPC分类号： C07D473/00 ,  C07D239/46 ,  C07D239/54 ,  A61K31/52 ,  A61K31/505

CPC分类号： C07D239/54 ,  C07D239/42 ,  C07D239/545 ,  C07D239/553 ,  C07D473/00 ,  Y02P20/55

公开(公告)号：EP0358154A2

公开(公告)日：1990-03-14

申请号：EP89116327.1

申请日：1989-09-05

申请人： NIPPON KAYAKU KABUSHIKI KAISHA

发明人： Ichikawa, Yuh-ichiro ,  Narita, Aya ,  Matsuo, Kaoru ,  Aoyama, Keiko ,  Matsumura, Fumiko ,  Nishiyama, Yukihiro ,  Matsubara, Kenichi ,  Nagahata, Takemitsu ,  Hoshino, Hiroo ,  Seki, Jun-ichi ,  Narasaka, Koichi ,  Hayashi, Yujiro

IPC分类号： C07D473/00 ,  C07D239/46 ,  C07D239/54 ,  A61K31/52 ,  A61K31/505

CPC分类号： C07D239/54 ,  C07D239/42 ,  C07D239/545 ,  C07D239/553 ,  C07D473/00 ,  Y02P20/55

摘要： This invention relates to cyclobutane derivatives represented by the following general formula (IV):
wherein B represents a nucleic acid base and R⁴ represents hydrogen atom or a protecting group, which is expectedly useful as an antiviral agent or a carcinostatic agent.

摘要翻译： 本发明涉及由以下通式（Ⅳ）表示的环丁烷衍生物：其中B表示核酸碱基，R 4表示氢原子或保护基团，其预期用作抗病毒剂或制癌剂 剂。

公开(公告)号：EP0493722A1

公开(公告)日：1992-07-08

申请号：EP91121327.0

申请日：1991-12-12

申请人： NIPPON KAYAKU KABUSHIKI KAISHA

发明人： Saito, Seiichi ,  Masuda, Akira ,  Kitagawa, Masayuki ,  Shimada, Nobuyoshi ,  Seki, Jun-ichi ,  Hoshino, Hiroo ,  Nishiyama, Yukihiro

IPC分类号： C07H19/02 ,  A61K31/70

CPC分类号： C07H19/02

摘要： It was found that 2-halogeno-oxetanocin A and 4'-phosphate thereof represented by the following general formula (1):

wherein X represents a halogen atom and R represents a hydrogen atom or a phosphoric acid residue

or salts thereof exhibit a strong antiviral activity and are useful as an active ingredient of therapeutic drug for viral diseases. Further, it was also found that the compounds of this invention are characterized in that they are not inactivated by adenosine deaminase widely present in living bodies and exhibit a high residual activity.

摘要翻译： 发现由以下通式（1）表示的2-卤代 - 氧杂环鸟菌素A和4'-磷酸酯：其中X表示卤素原子，R表示氢原子或磷酸残基或< 其盐具有强的抗病毒活性，可用作病毒性疾病的治疗药物的活性成分。 此外，还发现本发明的化合物的特征在于它们不被广泛存在于活体中的腺苷脱氨酶灭活并且表现出高残留活性。

公开(公告)号：EP0334250A3

公开(公告)日：1991-10-16

申请号：EP89104910.8

申请日：1989-03-18

申请人： Nippon Kayaku Kabushiki Kaisha

发明人： Saito, Seiichi ,  Hasegawa, Shigeru ,  Takahashi, Katsutoshi ,  Shimada, Nobuyoshi ,  Seki, Jun-ichi ,  Hoshino, Hiroo ,  Nishiyama, Yukihiro 8-25, Shiratori-2-chome ,  Matsubara, Kenichi ,  Nagahata, Takemitsu Senri Sakanoki Haitsu 208

IPC分类号： C07H19/16 ,  C07D473/00 ,  A61K31/52 ,  A61K31/70 ,  C12P19/40

CPC分类号： C07H19/02 ,  C07D305/06 ,  C07D305/08 ,  C07D305/10

摘要： This invention relates to oxetanocin-related compounds represented by the following formula (I):
[in formula (I), R 1 , Y and B have the following meanings: (a) R 1 represents -CH 2 0H or -CN 2 OCO-(alkyl), (b) Y represents
provided that R 2 is -H, -OH or -CHzOH and R 3 is -H, -OH, halogen atom, -CH 2 OH, lower alkyl group, -CH z -N 3 , -CH 2 -F, -N 3 , -COOH, -NH 2 , -CH 2 OSO 3 H or -CH 2 OCO-(lower alkyl), and (c) B represents a residue of purine base, (d) provided that R 1 and R 3 cannot simultaneously represente -CH 2 OH]
and their salts which have activities such as an antiviral activity and the like and are expectedly useful as a pharmaceutical and the like.

公开(公告)号：EP0468352A3

公开(公告)日：1992-07-15

申请号：EP91111925.3

申请日：1991-07-17

申请人： Nippon Kayaku Kabushiki Kaisha

发明人： Ichikawa, Yuh-ichiro ,  Akaba, Hiroshi ,  Sugawara, Yuka ,  Shiozawa, Akira ,  Matsubara, Kenichi ,  Nagahata, Takemitsu ,  Hoshino, Hiroo ,  Seki, Jun-ichi

IPC分类号： C07D473/34 ,  C07D473/18 ,  A61K31/52

CPC分类号： C07D239/54 ,  C07D473/00

摘要： A novel nucleic acid derivative represented by the following general formula (I) and physiologically acceptable salt thereof which are expected to have an antiviral activity:
wherein B represents a nucleic acid base derivative; A 1 and A 2 represent, independently of each other, OR 1 or OCOR 1 ; R 1 represents a hydrogen atom, a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group; ℓ represents a number of 0 or 1; and m and n each represents an integer of 0-2; provided that when ℓ and m are 0, n is 0 or 2.

公开(公告)号：EP0358154A3

公开(公告)日：1990-09-05

申请号：EP89116327.1

申请日：1989-09-05

申请人： NIPPON KAYAKU KABUSHIKI KAISHA

发明人： Ichikawa, Yuh-ichiro ,  Narita, Aya ,  Matsuo, Kaoru ,  Aoyama, Keiko ,  Matsumura, Fumiko ,  Nishiyama, Yukihiro ,  Matsubara, Kenichi ,  Nagahata, Takemitsu ,  Hoshino, Hiroo ,  Seki, Jun-ichi ,  Narasaka, Koichi ,  Hayashi, Yujiro

IPC分类号： C07D473/00 ,  C07D239/46 ,  C07D239/54 ,  A61K31/52 ,  A61K31/505

CPC分类号： C07D239/54 ,  C07D239/42 ,  C07D239/545 ,  C07D239/553 ,  C07D473/00 ,  Y02P20/55

摘要： This invention relates to cyclobutane derivatives represented by the following general formula (IV):
wherein B represents a nucleic acid base and R⁴ represents hydrogen atom or a protecting group, which is expectedly useful as an antiviral agent or a carcinostatic agent.