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公开(公告)号：EP0432630A2
公开(公告)日：1991-06-19
申请号：EP90123375.9
申请日：1990-12-06
发明人： Hanaoka, Miyoji , Ekimoto, Hisao , Kobayashi née Matsumura, Fumiko , Irie, Yukio , Takahashi, Katsutoshi
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： The present invention relates to compounds represented by formula A:
[wherein X⁻ is an acid residue], which exhibit both potent antitumor activity and platelet aggregation inhibition activity and are expected to be useful for the treatment of tumors.摘要翻译： 本发明涉及由式A表示的化合物：其中X - 为酸性残基，其表现出有效的抗肿瘤活性和血小板聚集抑制活性，并且预期可用于治疗肿瘤。
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2.发明公开Phosphoric acid esters of oxetanocins and process for producing the same as well as use thereof 失效Phosphorsäureestervon Oxetanocinen，Verfahren zu ihrer Herstellung sowie ihre Verwendung。
公开(公告)号：EP0392403A1
公开(公告)日：1990-10-17
申请号：EP90106714.0
申请日：1990-04-07
发明人： Saito, Seiichi , Hasegawa, Shigeru , Kitagawa, Masayuki , Shimada, Nobuyoshi , Takahashi, Katsutoshi , Seki, Jun-Ichi , Hoshino, Hiroo , Nishiyama, Yukihiro , Matsubara, Kenichi , Nagahata, Takemitsu
CPC分类号： C07H19/02
摘要： The present invention relates to phosphoric acid esters of oxetanocins having an antiviral activity which are represented by general formula (I):
wherein R, represents a phosphoric acid ester residue, X represents hydrogen, hydroxy or hydroxymethyl group, and B represents a purine base residue, and pharmacologically acceptable salts thereof.摘要翻译： 本发明涉及由通式（I）表示的具有抗病毒活性的氧杂环丁啶的磷酸酯：其中R1表示磷酸酯残基，X表示氢，羟基或羟甲基，B表示嘌呤 碱残基及其药理学上可接受的盐。
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公开(公告)号：EP0432630B1
公开(公告)日：1994-03-16
申请号：EP90123375.9
申请日：1990-12-06
发明人： Hanaoka, Miyoji , Ekimoto, Hisao , Kobayashi née Matsumura, Fumiko , Irie, Yukio , Takahashi, Katsutoshi
IPC分类号： A61K31/47
CPC分类号： A61K31/47
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公开(公告)号：EP0291917A3
公开(公告)日：1990-12-05
申请号：EP88107852.1
申请日：1988-05-17
发明人： Shimada, Nobuyoshi , Hasegawa, Shigeru , Tomizawa, Takayuki , Saito, Seiichi , Shibuya, Kyoichi , Fujii, Akio , Hoshino, Hiroo , Matsubara, Kenichi , Nagahata, Takemitsu , Takahashi, Katsutoshi , Nishiyama, Yukihiro
IPC分类号： C07D473/06 , A61K31/52 , C07D473/16 , C07D473/18 , C07D473/40
CPC分类号： C07D473/00 , C07D501/00 , C07H19/02
摘要： This invention relates to novel oxetanocins represented by the following general formula (I):
wherein R represents a group represented by
and their pharmacologically acceptable salts which have immunosuppressive and antiviral activities.-
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6.发明公开Use of oxetanocin-G for the treatment of varicella-zoster virus infections 失效OXETANOCIN-G用于治疗VARICELLA-ZOSTER病毒感染的应用
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7.发明公开Use of oxetanocin-G for the treatment of varicella-zoster virus infections 失效Verwendung von Oxetanocin-G zur Behandlung von Varicella-Zoster-Virus-Infektionen。
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8.发明公开Oxetanocin-related compounds and process for producing same 失效Oxetanocinderivate和Verfahren zu ihrer Herstellung。
公开(公告)号：EP0334250A2
公开(公告)日：1989-09-27
申请号：EP89104910.8
申请日：1989-03-18
发明人： Saito, Seiichi , Hasegawa, Shigeru , Takahashi, Katsutoshi , Shimada, Nobuyoshi , Seki, Jun-ichi , Hoshino, Hiroo , Nishiyama, Yukihiro 8-25, Shiratori-2-chome , Matsubara, Kenichi , Nagahata, Takemitsu Senri Sakanoki Haitsu 208
IPC分类号： C07H19/16 , C07D473/00 , A61K31/52 , A61K31/70 , C12P19/40
CPC分类号： C07H19/02 , C07D305/06 , C07D305/08 , C07D305/10
摘要： This invention relates to oxetanocin-related compounds represented by the following formula (I):
[in formula (I), R 1 , Y and B have the following meanings:
(a) R 1 represents -CH 2 0H or -CN 2 OCO-(alkyl),
(b) Y represents
provided that R 2 is -H, -OH or -CHzOH and R 3 is -H, -OH, halogen atom, -CH 2 OH, lower alkyl group, -CH z -N 3 , -CH 2 -F, -N 3 , -COOH, -NH 2 , -CH 2 OSO 3 H or -CH 2 OCO-(lower alkyl), and
(c) B represents a residue of purine base,
(d) provided that R 1 and R 3 cannot simultaneously represente -CH 2 OH]
and their salts which have activities such as an antiviral activity and the like and are expectedly useful as a pharmaceutical and the like.摘要翻译： 本发明涉及由下式（I）表示的氧杂环丁霉素相关化合物：
[式（I）中，R 1，Y和B具有以下含义：（a）R 1表示-CH 2 OH或-CH 2 OOC- ），（b）Y表示 ，条件是R2是-H，-OH或-CH2OH，R3是-H，-OH，卤素原子，-CH2OH，低级烷基，-CH2-N3，-CH2-F ，-N3，-COOH，-NH2，-CH2OSO3H或-CH2OCO-（低级烷基），（c）B表示嘌呤碱基的残基，（d）R1和R3不能同时表示-CH2OH] 其具有抗病毒活性等活性，并且预期可用作药物等。 -
公开(公告)号：EP0282672A1
公开(公告)日：1988-09-21
申请号：EP87307370.4
申请日：1987-08-20
CPC分类号： C07F15/0093
摘要： A diamine platinum (II) complex represented by the general formula
[wherein R₁ and R₂ are each a lower alkyl group; and two X's are each a halogen atom or jointly form a group represented by
(wherein R₃ and R₄ are each a hydrogen atom or a lower alkyl group) or a group represented by
(wherein m is 1 or 2)] is useful as an anti-tumour agent. They are prepared by reacting the diamine with M₂Pthal₄ to give the dihalogenodiamine complex which can be reacted after conversion to its diaqua complex, with the appropriate dicarboxylic acid.摘要翻译： 由通式
表示的二胺铂（II）络合物[其中R 1和R 2各自为低级烷基; 两个X分别为卤素原子或共同形成由 （其中R3和R4各自为氢原子或低级烷基）或由 表示的基团（其中m为1或2）表示的基团， ]作为抗肿瘤剂是有用的。 它们通过使二胺与M2Pthal4反应制得二卤代二胺络合物，其可以在转化成其二氨络合物后与适当的二羧酸反应。 -
公开(公告)号：EP0432630A3
公开(公告)日：1991-11-21
申请号：EP90123375.9
申请日：1990-12-06
发明人： Hanaoka, Miyoji , Ekimoto, Hisao , Kobayashi née Matsumura, Fumiko , Irie, Yukio , Takahashi, Katsutoshi
IPC分类号： A61K31/47
CPC分类号： A61K31/47
摘要： The present invention relates to compounds represented by formula A:
[wherein X⁻ is an acid residue], which exhibit both potent antitumor activity and platelet aggregation inhibition activity and are expected to be useful for the treatment of tumors.
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