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    BIOMARKERS OF ALZHEIMMER'S DISEASE PROGRESSION
    5.
    发明公开
    BIOMARKERS OF ALZHEIMMER'S DISEASE PROGRESSION 有权
    生物标记PROGRESSION阿尔茨海默病

    公开(公告)号：EP3066475A1

    公开(公告)日：2016-09-14

    申请号：EP14783620.9

    申请日：2014-10-10

    申请人： Nordic Bioscience A/S

    发明人： KARSDAL, Morten ,  HENRIKSEN, Kim

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6896 ,  G01N2333/47 ,  G01N2800/2821 ,  G01N2800/52

    摘要： Provided is a method for measuring the propensity of a patient to suffer progression of Alzheimer's disease that comprises, in either order: a) conducting a first immunoassay of a patient sample to determine the content (Tau-C′) of a C-terminal epitope present at the terminus of the amino acid sequence -SSTGSIDMVD (SEQ ID NO:1), and b) conducting a second immunoassay of the sample to determine the content (Tau-A′) of an N-terminal epitope present at the terminus of the amino acid sequence TPRGAAPPGQ- (SEQ ID NO:2), and c) calculating an index as a ratio Tau-A′/Tau-C′ between the second level and the first level. The method may be used to select patients for a clinical trial of an intervention in Alzheimer's disease or to evaluate a therapy.

    SCREENING FOR BONE ANABOLIC FACTORS
    9.
    发明公开
    SCREENING FOR BONE ANABOLIC FACTORS 审中-公开
    筛查骨形成的因素

    公开(公告)号：EP2135079A2

    公开(公告)日：2009-12-23

    申请号：EP08749558.6

    申请日：2008-04-14

    申请人： Nordic Bioscience A/S

    发明人： NEUTZSKY-WULFF, Anita, Vibsig ,  HENRIKSEN, Kim ,  KARSDAL, Morten

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5044 ,  G01N33/5041 ,  G01N2333/726

    摘要： A method for screening for modulators of the secretion by an osteoclast of a wnt or a wnt signal enhancer comprises exposing osteoclasts in culture to a compound to be screened, exposing a wnt sensitive detection system to conditioned medium from said osteoclast culture, and determining whether a wnt signal is present in said medium by assaying for wnt mediated activation of bone formation by osteoblasts or by wnt mediated activation of LRP5 and or LPR6 signalling in a cell by detection of β catenin or detection of translocation of dishevelled, axin, or Fratl to the cell membrane of said cell.