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公开(公告)号：EP2895144B1
公开(公告)日：2017-01-11
申请号：EP13759781.1
申请日：2013-09-12
申请人： Novaliq GmbH
IPC分类号： A61K9/00 , A61K47/06 , A61K9/08 , A61K31/232 , A61P27/02
CPC分类号： A61K47/06 , A61K9/0048 , A61K9/08 , A61K31/02 , A61K31/07 , A61K31/11 , A61K31/202 , A61K31/203 , A61K31/232 , A61K31/436 , A61K31/4418 , A61K45/06 , A61K2300/00
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公开(公告)号：EP2806886B1
公开(公告)日：2017-03-01
申请号：EP13700911.4
申请日：2013-01-22
申请人： Novaliq GmbH
发明人： GÜNTHER, Bernhard , THEISINGER, Bastian , THEISINGER, Sonja , SCHERER, Dieter , WILSON, Clive , PETTIGREW, Anthony , HÜTTIG, Annette
CPC分类号： A61K47/06 , A61K9/0019 , A61K9/0048 , A61K38/23 , A61K38/28 , A61K38/385 , A61K38/4826 , A61K47/24 , C12Y304/21001
摘要： The invention provides novel compositions of bioactive polypeptides and proteins with improved stability and shelf-life. The compositions are based on liquid vehicles selected from semifluorinated alkanes. These vehicles are remarkably effective in protecting polypeptides and proteins from degradation and/or aggregation. The compositions are useful for topical administration, e.g. into an eye, or by parenteral injection, e.g. via the subcutaneous or intramuscular route.
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公开(公告)号：EP3024484A1
公开(公告)日：2016-06-01
申请号：EP14742509.4
申请日：2014-07-23
申请人： Novaliq GmbH
IPC分类号： A61K39/395 , A61K47/06 , C07K16/28
CPC分类号： C07K16/28 , A61K39/395 , A61K39/39591 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： The invention provides novel compositions of antibodies based on liquid vehicles selected from semifluorinated alkanes. The use of these vehicles provides for improved stability and shelf-life of antibodies and their derivatives. The compositions are useful for topical administration or for parenteral injection.
摘要翻译： 本发明提供基于选自半氟烷烃的液体载体的抗体的新型组合物。 使用这些载体可提供抗体及其衍生物的稳定性和保质期。 该组合物可用于局部给药或胃肠外注射。
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公开(公告)号：EP4342537A2
公开(公告)日：2024-03-27
申请号：EP23207893.1
申请日：2013-09-12
申请人： Novaliq GmbH
发明人： GÜNTHER, Bernhard , SCHERER, Dieter , PETTIGREW, Anthony , THEISINGER, Bastian , THEISINGER, Sonja
IPC分类号： A61P27/00
摘要： The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue. The invention further provides kits comprising such compositions.
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公开(公告)号：EP3024484B1
公开(公告)日：2018-06-20
申请号：EP14742509.4
申请日：2014-07-23
申请人： Novaliq GmbH
IPC分类号： A61K39/395 , A61K47/06 , C07K16/28
CPC分类号： C07K16/28 , A61K39/395 , A61K39/39591 , C07K2317/21 , C07K2317/24 , C07K2317/55 , C07K2317/569 , C07K2317/622 , C07K2317/626 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： The invention provides novel compositions of antibodies based on liquid vehicles selected from semifluorinated alkanes. The use of these vehicles provides for improved stability and shelf-life of antibodies and their derivatives. The compositions are useful for topical administration or for parenteral injection.
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公开(公告)号：EP2895144A1
公开(公告)日：2015-07-22
申请号：EP13759781.1
申请日：2013-09-12
申请人： Novaliq GmbH
IPC分类号： A61K9/00 , A61K47/06 , A61K9/08 , A61K31/232 , A61P27/02
CPC分类号： A61K47/06 , A61K9/0048 , A61K9/08 , A61K31/02 , A61K31/07 , A61K31/11 , A61K31/202 , A61K31/203 , A61K31/232 , A61K31/436 , A61K31/4418 , A61K45/06 , A61K2300/00
摘要： The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue. The invention further provides kits comprising such compositions.
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7.发明公开STABILISED PROTEIN COMPOSITIONS BASED ON SEMIFLUORINATED ALKANES 有权STABILISIERTE PROTEINZUSAMMENSETZUNGEN AUF BASIS SEMIFLUORIERTER ALKANE
公开(公告)号：EP2806886A1
公开(公告)日：2014-12-03
申请号：EP13700911.4
申请日：2013-01-22
申请人： Novaliq GmbH
发明人： GÜNTHER, Bernhard , THEISINGER, Bastian , THEISINGER, Sonja , SCHERER, Dieter , WILSON, Clive , PETTIGREW, Anthony , HÜTTIG, Annette
CPC分类号： A61K47/06 , A61K9/0019 , A61K9/0048 , A61K38/23 , A61K38/28 , A61K38/385 , A61K38/4826 , A61K47/24 , C12Y304/21001
摘要： The invention provides novel compositions of bioactive polypeptides and proteins with improved stability and shelf-life. The compositions are based on liquid vehicles selected from semifluorinated alkanes. These vehicles are remarkably effective in protecting polypeptides and proteins from degradation and/or aggregation. The compositions are useful for topical administration, e.g. into an eye, or by parenteral injection, e.g. via the subcutaneous or intramuscular route.
摘要翻译： 本发明提供具有改善的稳定性和保质期的生物活性多肽和蛋白质的新组合物。 所述组合物基于选自半氟化烷烃的液体载体。 这些载体在保护多肽和蛋白质免于降解和/或聚集方面非常有效。 组合物可用于局部给药，例如， 进入眼睛，或通过肠胃外注射，例如， 通过皮下或肌内途径。
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公开(公告)号：EP4342537A3
公开(公告)日：2024-07-03
申请号：EP23207893.1
申请日：2013-09-12
申请人： Novaliq GmbH
发明人： GÜNTHER, Bernhard , SCHERER, Dieter , PETTIGREW, Anthony , THEISINGER, Bastian , THEISINGER, Sonja
CPC分类号： A61K45/06 , A61K9/0048 , A61K9/08 , A61K31/436 , A61K31/07 , A61K31/11 , A61K31/202 , A61K31/203 , A61K31/232 , A61K31/4418 , A61P27/02 , A61P27/04 , A61K47/06 , A61P27/00 , A61P27/14 , A61P29/00 , A61P37/02 , A61P37/06 , A61P43/00 , A61P5/38 , A61K31/02
摘要： The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue. The invention further provides kits comprising such compositions.
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公开(公告)号：EP3488847A1
公开(公告)日：2019-05-29
申请号：EP18209639.6
申请日：2013-09-12
申请人： Novaliq GmbH
摘要： The invention provides novel compositions comprising semifluorinated alkanes and at least one compound sensitive or prone to oxidation. The compositions can be used as medicines that are topically administered to an eye or ophthalmic tissue. The invention further provides kits comprising such compositions.
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