专利检索 ap:("Novartis AG") AND inv:"FIRESTONE, Brant, Geoffrey" 第 1 页

1.

发明公开
BIOMARKERS FOR IAP INHIBITOR COMPOUNDS 审中-公开
标题翻译：生物标记IAP抑制剂的化合物

公开(公告)号：EP2478358A1

公开(公告)日：2012-07-25

申请号：EP10757143.2

申请日：2010-09-17

申请人： Novartis AG

发明人： FIRESTONE, Brant, Geoffrey , LEVINE, Kymberly , PORTER, Dale, Alan , SULLIVAN, John , ZAWEL, Leigh

IPC分类号： G01N33/50

CPC分类号： G01N33/6863 , A61K31/427 , A61K31/44 , A61K31/4439 , G01N2333/525 , G01N2333/5255 , G01N2333/70575

摘要： A method to predict which patients will respond to a IAP inhibiting compound comprising administering an IAP inhibitor compound to a patient, and measuring IL1B, Lymphotoxin alpha (LTa), TWEAK, LIGHT, Fas, TNF alpha or TRAIL levels.

2.

发明公开
COMBINATIONS OF VASCULAR DISRUPTING AGENTS WITH INHIBITOR OF APOPTOSIS PROTEINS ANTAGONISTS 审中-公开
标题翻译： VESSEL破坏性剂的组合药物和细胞凋亡蛋白拮抗剂抑制剂

公开(公告)号：EP2464347A1

公开(公告)日：2012-06-20

申请号：EP10747348.0

申请日：2010-08-11

申请人： Novartis AG

发明人： CONWAY, Colleen , FIRESTONE, Brant, Geoffrey , ZAWEL, Leigh

IPC分类号： A61K31/352 , A61K31/427 , A61K31/4439 , A61P35/00

CPC分类号： C07D417/04 , A61K31/352 , A61K31/427 , A61K31/4439 , A61K45/06 , A61K2300/00

摘要： The invention relates to combinations comprising a vascular disrupting agent (VDA) with IAP antagonists, for simultaneous, concurrent, separate or sequential use, especially for use in the treatment of proliferative diseases.