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1.
公开(公告)号:EP3698796A1
公开(公告)日:2020-08-26
申请号:EP20165564.4
申请日:2017-09-28
申请人: Novartis AG
发明人: CASAREZ, Anthony , FUREGATI, Markus , KOCH, Guido , LIN, Xiaodong , OSSOLA, Flavio , RECK, Folkert , SIMMONS, Robert Lowell , ZHU, Qingming
IPC分类号: A61K31/535 , A61P31/04
摘要: This invention pertains generally to compounds of Formula (A),
as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.-
公开(公告)号:EP3519419B1
公开(公告)日:2020-05-27
申请号:EP17791737.4
申请日:2017-09-28
申请人: Novartis AG
发明人: CASAREZ, Anthony , FUREGATI, Markus , KOCH, Guido , LIN, Xiaodong , OSSOLA, Flavio , RECK, Folkert , SIMMONS, Robert Lowell , ZHU, Qingming
IPC分类号: C07D471/18 , A61K31/496 , A61K45/06 , A61K31/5025 , A61K31/551 , A61K31/546 , A61K31/407 , A61P31/04 , A61K31/427 , A61K31/431 , A61K31/4545
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公开(公告)号:EP3519419A1
公开(公告)日:2019-08-07
申请号:EP17791737.4
申请日:2017-09-28
申请人: Novartis AG
发明人: CASAREZ, Anthony , FUREGATI, Markus , KOCH, Guido , LIN, Xiaodong , OSSOLA, Flavio , RECK, Folkert , SIMMONS, Robert Lowell , ZHU, Qingming
IPC分类号: C07D519/06 , A61K31/535 , A61P31/04 , C07D471/18
摘要: as further described herein, which act as beta-lactamase inhibitors, and salts, crystalline forms and formulations thereof. In certain aspects, the invention pertains to methods of using such compounds in combination with a beta-lactam antibiotic to treat infections caused by Gram-negative bacteria, including drug-resistant strains.
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4.
公开(公告)号:EP4347596A1
公开(公告)日:2024-04-10
申请号:EP22729790.0
申请日:2022-05-24
申请人: Novartis AG
发明人: BORDAS, Vincent , BRUN, Jvan , DECKER, Andrea , FUREGATI, Markus , GOGNIAT, Geoffrey , GONG, Wanben , HAMON, Jacques , HINRICHS, Juergen Hans-Hermann , HOLZER, Philipp , LIMAM, Fatma , MOEBITZ, Henrik , NOCITO, Sandro , PLATTNER, Simone , SCHMIEDEBERG, Niko , SCHOEPFER, Joseph , SOTO, Jessica , STRANG, Ross , YAO, Shuping , YU, Huangchao , ZECRI, Frédéric , ZHANG, Sisi
IPC分类号: C07D487/04 , A61P35/00 , A61K31/519
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