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公开(公告)号：EP3898621A1
公开(公告)日：2021-10-27
申请号：EP19836572.8
申请日：2019-12-18
申请人： Novartis AG
发明人： AZIMIOARA, Mihai , BURSULAYA, Badry , JIANG, Songchun , MATHISON, Casey Jacob Nelson , NIKULIN, Victor Ivanovich , NGUYEN, Truc Ngoc , OKRAM, Barun , PATEL, Sejal , PHILLIPS, Dean Paul , WHITEHEAD, Lewis , WU, Baogen , YAN, Shanshan , ZHU, Xuefeng
IPC分类号： C07D417/04 , C07D419/14 , A61P11/00 , A61K31/4985
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2.发明公开BENZENE-FUSED 6-MEMBERED OXYGEN-CONTAINING HETEROCYCLIC DERIVATIVES OF BICYCLIC HETEROARYLS 审中-公开BENZOLKONDENSIERTE 6元含氧杂环双环杂芳基衍生物
公开(公告)号：EP2504339A1
公开(公告)日：2012-10-03
申请号：EP10779562.7
申请日：2010-11-23
发明人： CHEN, Bei , FAIRHURST, Robin, Alec , FLOERSHEIMER, Andreas , FURET, Pascal , JIANG, Songchun , LU, Wenshuo , MARSILJE, Thomas, H. , VAUPEL, Andrea
IPC分类号： C07D487/04 , C07D513/08 , A61K31/4985 , A61K31/519 , A61K31/537 , A61K31/541 , A61P35/00
CPC分类号： C07D513/08 , C07D487/04
摘要： The invention relates to new derivatives of formula I, wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of a proliferative disease.
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公开(公告)号：EP4059934A1
公开(公告)日：2022-09-21
申请号：EP21208454.5
申请日：2017-09-06
申请人： Novartis AG
发明人： ALPER, Phillip , DEANE, Jonathan , JIANG, Songchun , JIANG, Tao , KNOEPFEL, Thomas , MICHELLYS, Pierre-Yves , MUTNICK, Daniel , PEI, Wei , SYKA, Peter , ZHANG, Guobao , ZHANG, Yi
IPC分类号： C07D471/04 , A61K31/437 , A61P37/00
摘要： The invention disclosed herein relates to 4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridinyl compounds and 4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridinyl compounds of Formula (A), pharmaceutical compositions comprising such compounds and the use of such compounds in the treatment of autoimmune diseases.
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公开(公告)号：EP3510033A1
公开(公告)日：2019-07-17
申请号：EP17777966.7
申请日：2017-09-06
申请人： Novartis AG
发明人： ALPER, Phillip , DEANE, Jonathan , JIANG, Songchun , JIANG, Tao , KNOEPFEL, Thomas , MICHELLYS, Pierre-Yves , MUTNICK, Daniel , PEI, Wei , SYKA, Peter , ZHANG, Guobao , ZHANG, Yi
IPC分类号： C07D471/04 , A61K31/437 , A61P37/00
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公开(公告)号：EP2475668A1
公开(公告)日：2012-07-18
申请号：EP10763143.4
申请日：2010-09-10
申请人： Novartis AG , IRM LLC
发明人： CHEN, Bei , FAIRHURST, Robin, Alec , FLOERSHEIMER, Andreas , FURET, Pascal , GUAGNANO, Vito , JIANG, Songchun , LU, Wenshuo , MARSILJE, Thomas, H. , MCCARTHY, Clive , MICHELLYS, Pierre-Yves , STAUFFER, Frédéric , STUTZ, Stefan , VAUPEL, Andrea
IPC分类号： C07D487/04 , A61K31/4985 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K9/2009 , A61K9/2013 , A61K9/2018 , A61K9/2059 , A61K9/4858
摘要： The invention relates to compounds of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; such compounds as a medicament; such compounds for the treatment of a proliferative disease.
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公开(公告)号：EP3257848A1
公开(公告)日：2017-12-20
申请号：EP17176482.2
申请日：2013-06-05
申请人： Novartis AG
发明人： LELAIS, Gerald , EPPLE, Robert , MARSILJE III, Thomas H. , MICHELLYS, Pierre-Yves , MCNEILL, Matthew H. , LONG, Yun , LU, Wenshuo , CHEN, Bei , BURSULAYA, Badry , JIANG, Songchun
IPC分类号： C07D401/14 , C07D413/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D471/04 , C07D513/04 , A61K31/4439 , C07D405/14 , A61K45/06 , A61K31/4184 , A61K31/454 , A61K31/4545 , A61K31/55 , A61K31/551 , A61K31/553 , C07D401/04 , C07D417/14
CPC分类号： C07D401/14 , A61K31/4184 , A61K31/454 , A61K31/4545 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful for modulating EGFR activity, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated EGFR activity.
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公开(公告)号：EP2773635B1
公开(公告)日：2017-08-02
申请号：EP13729219.9
申请日：2013-06-05
申请人： Novartis AG
发明人： LELAIS, Gerald , EPPLE, Robert , MARSILJE, III, Thomas H. , MICHELLYS, Pierre-Yves , MCNEILL, Matthew H. , LONG, Yun , LU, Wenshuo , CHEN, Bei , BURSULAYA, Badry , JIANG, Songchun
IPC分类号： C07D401/14 , C07D413/14 , C07D403/04 , C07D403/14 , C07D413/04 , C07D471/04 , C07D513/04 , A61K31/4439
CPC分类号： C07D401/14 , A61K31/4184 , A61K31/454 , A61K31/4545 , A61K31/55 , A61K31/551 , A61K31/553 , A61K45/06 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14 , C07D471/04 , C07D513/04
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8.发明公开
公开(公告)号：EP2683722A1
公开(公告)日：2014-01-15
申请号：EP12710794.4
申请日：2012-03-08
申请人： Novartis AG , IRM LLC
发明人： CHEN, Bai , FAIRHURST, Robin Alec , JIANG, Songchun , LU, Wenshuo , MARSILJE III, Thomas H. , MCCARTHY, Clive , MICHELLYS, Pierre-Yves , STUTZ, Stefan
IPC分类号： C07D487/04 , C07D519/00 , A61K31/519 , A61P35/00
CPC分类号： C07D487/04 , A61K31/519 , A61K31/541 , A61K45/06 , C07D519/00
摘要： The present invention provides a compound of formula (I); a method for manufacturing the compounds of the invention, and its use as a IGF-1R inhibitor. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
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