公开(公告)号：EP0907731A1

公开(公告)日：1999-04-14

申请号：EP97908260.0

申请日：1997-03-19

申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

发明人： KAUPMANN, Klemens ,  BETTLER, Bernhard ,  BITTIGER, Helmut ,  FRÖSTL, Wolfgang ,  MICKEL, Stuart, John

IPC分类号： A01K67 ,  C07F9 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N15 ,  C12P21 ,  C12Q1 ,  G01N33 ,  A61K38

CPC分类号： C07K14/70571 ,  A01K2217/05 ,  A61K38/00 ,  C07F9/301

摘要： The present invention provides purified GABAB receptors and receptor proteins derived from rat and human sources, as well as nucleic acids which encode such proteins. The proteins and nucleic acids of the invention share significant homology with the GABAB receptor and the DNA encoding it as specifically disclosed herein. The invention moreover provides methods for isolating other members of the GABAB receptor family using DNA cloning technology and probes derived from the sequences provided herein, as well as novel members of the GABAB receptor family isolated by such methods. Furthermore, the invention relates to the use of GABAB receptors and receptor proteins and cells transformed with a gene encoding a GABAB receptor protein in a method for identifying and characterising compounds which modulate the activity of the GABAB receptor, such as GABAB receptor agonists and antagonists, which may be useful as pharmacological agents for the treatment of disorders associated with the central and peripheral nervous systems.

公开(公告)号：EP1423427A2

公开(公告)日：2004-06-02

申请号：EP02767429.0

申请日：2002-08-26

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BARSKE, Carmen ,  FRENTZEL, Stefan ,  KAUPMANN, Klemens ,  MIR, Anis, Khusro ,  SOMMER, Bernd, Josef

IPC分类号： C07K14/71

CPC分类号： C07K14/705

摘要： This invention relates to gene polypeptides and polynucleotides that encode proteins of the Nogo-66 receptor (NgR) family and are therefore called NgR homologue 2 (NgRH2). The invention further relates to their use in identifying compounds that may be agonists or antagonists that are potentially useful in regeneration and protection of the nervous system, and to production of NgRH2 polypeptides, derivatives, and antibodies.

公开(公告)号：EP0907731B1

公开(公告)日：2005-03-02

申请号：EP97908260.9

申请日：1997-03-19

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： KAUPMANN, Klemens ,  BETTLER, Bernhard ,  BITTIGER, Helmut ,  FRÖSTL, Wolfgang ,  MICKEL, Stuart, John

IPC分类号： C12N15/12 ,  C07K14/705 ,  C07K16/28 ,  G01N33/68 ,  C07F9/30 ,  C12N15/11 ,  A01K67/027

CPC分类号： C07K14/70571 ,  A01K2217/05 ,  A61K38/00 ,  C07F9/301

摘要： The present invention provides purified GABAB receptors and receptor proteins derived from rat and human sources, as well as nucleic acids which encode such proteins. The proteins and nucleic acids of the invention share significant homology with the GABAB receptor and the DNA encoding it as specifically disclosed herein. The invention moreover provides methods for isolating other members of the GABAB receptor family using DNA cloning technology and probes derived from the sequences provided herein, as well as novel members of the GABAB receptor family isolated by such methods. Furthermore, the invention relates to the use of GABAB receptors and receptor proteins and cells transformed with a gene encoding a GABAB receptor protein in a method for identifying and characterising compounds which modulate the activity of the GABAB receptor, such as GABAB receptor agonists and antagonists, which may be useful as pharmacological agents for the treatment of disorders associated with the central and peripheral nervous systems.

公开(公告)号：EP1440091A1

公开(公告)日：2004-07-28

申请号：EP02785261.5

申请日：2002-10-21

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BARSKE, Carmen ,  FRENTZEL, Stefan ,  HEIN, Andreas, Edgar ,  KAUPMANN, Klemens ,  SOMMER, Bernd, Josef

IPC分类号： C07K14/705 ,  C12N15/12 ,  C07K16/28 ,  C12N15/62

CPC分类号： C07K16/28 ,  A61K2039/505 ,  C07K14/705 ,  C07K16/2863 ,  C07K2317/34

摘要： This invention relates to gene polypeptides and polynucleotides that encode proteins of the Nogo-66 receptor (NgR) family and are therefore called NgR homologue 1 (NgRH1). The invention further relates to their use in identifying compounds that may be agonists or antagonists that are potentially useful in regeneration and protection of the nervous system, and to production of NgRH1 polypeptides, derivatives, and antibodies.

公开(公告)号：EP1896428A1

公开(公告)日：2008-03-12

申请号：EP06762168.0

申请日：2006-06-23

申请人： Novartis AG

发明人： FLOERSHEIM, Philipp ,  FROESTL, Wolfgang ,  GUERY, Sebastien ,  KAUPMANN, Klemens ,  KOLLER, Manuel

IPC分类号： C07D239/42 ,  C07D239/48 ,  C07D403/12 ,  C07D405/04 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07F9/02 ,  C07F7/02 ,  A61K31/495 ,  A61P25/00

CPC分类号： C07F9/65122 ,  C07D239/42 ,  C07D239/48 ,  C07D403/12 ,  C07D405/04 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  C07F7/0812

摘要： The invention relates to novel heterocyclic compounds of the formula (I) in free base form or in acid addition salt form, in which R1, R2, R3, R4 and A are as defined in the specification, to their preparation, to their use as medicaments for the treatment of certain nervous system disorders and to medicaments comprising them.

公开(公告)号：EP1423519A2

公开(公告)日：2004-06-02

申请号：EP02767430.8

申请日：2002-08-26

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： KAUPMANN, Klemens

IPC分类号： C12N15/10 ,  C12N15/12 ,  C12N15/63 ,  C07K14/705 ,  C07K16/28 ,  G01N33/68

CPC分类号： C07K14/705 ,  A61K38/00 ,  C07K2319/00

摘要： This invention relates to newly identified polypeptides and polynucleotides encoding such polypeptides, to their use in diagnosis and in identifying compounds that may be agonists, antagonists that are potentially useful in therapy, and to production of such polypeptides and polynucleotides, belonging to the class of G-protein coupled receptors.

公开(公告)号：EP1402035A2

公开(公告)日：2004-03-31

申请号：EP02747403.0

申请日：2002-06-17

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： KAUPMANN, Klemens

IPC分类号： C12N15/12 ,  C07K14/705 ,  C12N15/62 ,  C07K16/28 ,  G01N33/68

CPC分类号： C07K14/705 ,  C07K2319/00

摘要： This invention relates polypeptides and polynucleotides encoding proteins of the GABA B receptor family, to their use in diagnosis and identifying compounds that may be agonists, antagonists that are potentially useful in therapy of such polypeptides and polynucleotides, belonging to the class of G-protein coupled receptors.