公开(公告)号：EP2285808A1

公开(公告)日：2011-02-23

申请号：EP09737965.5

申请日：2009-04-01

申请人： Novartis AG

发明人： ANG, Shi Hua ,  KRASTEL, Philipp ,  LEONG, Seh Yong ,  TAN, Liying Jocelyn ,  WONG, Wei Lin Josephine ,  YEUNG, Bryan KS ,  ZOU, Bin

IPC分类号： C07D471/20 ,  C07D487/20 ,  A61K31/437 ,  A61K31/55 ,  A61K31/407 ,  A61P33/02 ,  A61P33/06 ,  A61K31/424 ,  A61K31/438 ,  C07D498/22

CPC分类号： C07D471/20 ,  C07D487/20 ,  C07D498/22

摘要： The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by
Plasmodium falciparum ,
Plasmodium vivax ,
Plasmodium malariae ,
Plasmodium ovale ,
Trypanosoma cruzi and parasites of the
Leishmania genus such as, for example,
Leishmania donovani . The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.

公开(公告)号：EP2925757B1

公开(公告)日：2017-10-04

申请号：EP13795977.1

申请日：2013-11-18

申请人： Novartis AG

发明人： CHATTERJEE, Arnab Kumar ,  NAGLE, Advait Suresh ,  PARASELLI, Prasuna ,  KONDREDDI, Ravinder Reddy ,  LEONG, Seh Yong ,  MISHRA, Pranab Kumar ,  MOREAU, Robert Joseph ,  ROLAND, Jason Thomas ,  SIM, Wei Lin Sandra ,  SIMON, Oliver ,  TAN, Liying Jocelyn ,  YEUNG, Bryan KS ,  ZOU, Bin ,  BOLLU, Venkatataiah

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P33/06

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06 ,  C07D519/00

公开(公告)号：EP2925757A1

公开(公告)日：2015-10-07

申请号：EP13795977.1

申请日：2013-11-18

申请人： Novartis AG

发明人： CHATTERJEE, Arnab Kumar ,  NAGLE, Advait Suresh ,  PARASELLI, Prasuna ,  KONDREDDI, Ravinder Reddy ,  LEONG, Seh Yong ,  MISHRA, Pranab Kumar ,  MOREAU, Robert Joseph ,  ROLAND, Jason Thomas ,  SIM, Wei Lin Sandra ,  SIMON, Oliver ,  TAN, Liying Jocelyn ,  YEUNG, Bryan KS ,  ZOU, Bin ,  BOLLU, Venkatataiah

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P33/06

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/506 ,  A61K31/538 ,  A61K45/06 ,  C07D519/00

摘要： The present invention provides compounds of formula I: [INSERT FORMULA HERE] or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a Plasmodium parasite, such as malaria.

摘要翻译： 本发明提供式I化合物或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明进一步提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由疟原虫等疟原虫引起的疾病的病理和/或症状的方法。

公开(公告)号：EP2970324A1

公开(公告)日：2016-01-20

申请号：EP14720357.4

申请日：2014-03-13

申请人： Novartis AG

发明人： JIRICEK, Jan ,  LIANG, Fang ,  MATHISON, Casey Jacob Nelson ,  MISHRA, Pranab Kumar ,  MOLTENI, Valentie ,  NAGLE, Advait Suresh ,  SUPEK, Frantisek ,  TAN, Liying Jocelyn ,  BIGGART, Agnes ,  YEH, Vince

IPC分类号： C07D491/08 ,  C07D487/04 ,  C07D491/107 ,  A61K31/519 ,  A61P33/02

CPC分类号： A61K31/519 ,  A61K31/5377 ,  A61K31/553 ,  A61K31/695 ,  C07D487/04 ,  C07D491/08 ,  C07D491/107 ,  C07D519/00 ,  C07F7/0814 ,  Y02A50/409 ,  Y02A50/414 ,  Y02A50/415

摘要： The present invention provides compounds of formula (I): (Formula (I)) or a pharmaceutically acceptable salt, tautomer, or stereoisomer, thereof, wherein the variables are as defined herein. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating, preventing, inhibiting, ameliorating, or eradicating the pathology and/or symptomology of a disease caused by a parasite, such as Leishmaniasis, Human African Trypanosomiasis and Chagas disease.

摘要翻译： 本发明提供式（I）化合物：（式（I））或其药学上可接受的盐，互变异构体或立体异构体，其中变量如本文所定义。 本发明还提供包含这些化合物的药物组合物和使用这些化合物治疗，预防，抑制，改善或消除由寄生虫引起的疾病的病理和/或症状的方法，例如利什曼病，人非洲锥虫病和奇加斯 疾病。

公开(公告)号：EP2285808B1

公开(公告)日：2013-11-20

申请号：EP09737965.5

申请日：2009-04-01

申请人： Novartis AG

发明人： ANG, Shi Hua ,  KRASTEL, Philipp ,  LEONG, Seh Yong ,  TAN, Liying Jocelyn ,  WONG, Wei Lin Josephine ,  YEUNG, Bryan KS ,  ZOU, Bin

IPC分类号： C07D471/20 ,  C07D487/20 ,  A61K31/437 ,  A61K31/55 ,  A61K31/407 ,  A61P33/02 ,  A61P33/06 ,  A61K31/424 ,  A61K31/438 ,  C07D498/22

CPC分类号： C07D471/20 ,  C07D487/20 ,  C07D498/22

摘要： The invention relates to organic compounds which have interesting pharmaceutical properties. In particular, the compounds are useful in the treatment and/or prevention of infections such as those caused by Plasmodium falciparum, Plasmodium vivax, Plasmodium malariae, Plasmodium ovale, Trypanosoma cruzi and parasites of the Leishmania genus such as, for example, Leishmania donovani. The invention also relates to pharmaceutical compositions containing the compounds, as well as processes for their preparation.