公开(公告)号：EP0780394A1

公开(公告)日：1997-06-25

申请号：EP96810863.9

申请日：1996-12-11

申请人： Novartis AG

发明人： Stanetty, Peter ,  Kunz, Walter

IPC分类号： C07D513/04 ,  A01N43/90 ,  C07D333/36

CPC分类号： C07D513/04 ,  A01N43/90 ,  C07D333/36

摘要： Die Erfindung betrifft neue mikrobizid und pflanzenimmunisierend wirksame Verbindungen der Formel I,
worin bedeuten:

X Wasserstoff, Halogen, C 1 -C 4 -Alkyl, SR 8 , N(R 9 )R 10 , CH 2 OH, CHO, COOR 8 ;
R 8 bis R 10 Wasserstoff, C 1 -C 4 -Alkyl, Benzyl, C 1 -C 4 -Acyl oder Benzoyl;
Z Wasserstoff, Halogen oder eine Methyl-Gruppe, die unsubstituiert ist oder an die 1-3 gegebenenfalls substituierte Heteroatome O, S und/oder N gebunden sind;
in freier Form oder in Salzform.
Sie können im Pflanzenschutz zur Bekämpfung und Verhütung von Krankheitsbefall verwendet werden.

摘要翻译： 式（I）的噻吩并[2,3-d] 1,2,3-噻二唑及其盐是新的。 X = H，卤素，1-4C烷基，SR8，NR9R10，CH2OH，CHO或COOR8; R8-R10 = H，1-4C烷基，苄基，1-4C酰基或苯甲酰基; Z = H，卤素或甲基（任选被1-3个任选取代的杂原子（O，S和/或N）取代）; 条件是当X是COOEt时Z不是甲基。 还要求的是式（II）的四氢呋喃腙中间体和式（III）的有机锂化合物作为非质子溶剂中的溶液。 T = COY，CONY2，SO2Y或COOU; U = 1-8C烷基或芳基（均可任意取代）; 和Y = H或对于U.

公开(公告)号：EP0780372A2

公开(公告)日：1997-06-25

申请号：EP96810865.4

申请日：1996-12-12

申请人： Novartis AG

发明人： Kunz, Walter ,  Jau, Beat

IPC分类号： C07C323/63 ,  C07C327/26 ,  C07D277/82 ,  C07C335/22 ,  C07D285/14

CPC分类号： C07D285/14 ,  C07C319/02 ,  C07C319/12 ,  C07C323/63 ,  C07C327/26 ,  C07C335/22 ,  C07D277/82

摘要： Compounds of the formula I
and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III

In the compounds of the formulae I and III:

X is halogen,
n is 0, 1, 2 or 3;
Z is CN, CO-A or CS-A,
A is hydrogen, halogen, OR 1 , SR 2 and N(R 3 )R 4 ;
R 1 to R 4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R 3 and R 4 , together with the nitrogen atom to which they are bonded, are a 5- or 6-membered, substituted or unsubstituted heterocyclic radical having 1-3 heteroatoms O, S and/or N.

Processes for the preparation of compounds of the formula I are described.

摘要翻译： 式I化合物＆lt; CHEM＆gt;及其二硫化物及其盐是制备具有杀微生物和植物免疫作用的式III化合物的重要中间产物。在式I和III化合物中：X 是卤素，n是0,1,2或3; Z是CN，CO-A或CS-A，A是氢，卤素，OR1，SR2和N（R3）R4; R 1至R 4为氢，取代或未取代的含有不超过8个碳原子的开链，饱和或不饱和烃基，取代或未取代的含有不多于10个碳原子的环状，饱和或不饱和烃基，取代或未取代的 苄基或苯乙基，取代或未取代的含有不超过8个碳原子的烷酰基，取代或未取代的苯甲酰基或取代或未取代的杂环基; 或R 3和R 4与它们所键合的氮原子一起是具有1-3个杂原子O，S和/或N的5或6元取代或未取代的杂环基。用于制备 描述了式I。

公开(公告)号：EP0780372A3

公开(公告)日：1997-09-17

申请号：EP96810865.4

申请日：1996-12-12

申请人： Novartis AG

发明人： Kunz, Walter ,  Jau, Beat

IPC分类号： C07C323/63 ,  C07C327/26 ,  C07D277/82 ,  C07C335/22 ,  C07D285/14

CPC分类号： C07D285/14 ,  C07C319/02 ,  C07C319/12 ,  C07C323/63 ,  C07C327/26 ,  C07C335/22 ,  C07D277/82

摘要： Compounds of the formula I
and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III
In the compounds of the formulae I and III:
X is halogen, n is 0, 1, 2 or 3; Z is CN, CO-A or CS-A, A is hydrogen, halogen, OR 1 , SR 2 and N(R 3 )R 4 ; R 1 to R 4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R 3 and R 4 , together with the nitrogen atom to which they are bonded, are a 5- or 6-membered, substituted or unsubstituted heterocyclic radical having 1-3 heteroatoms O, S and/or N. Processes for the preparation of compounds of the formula I are described.

摘要翻译： 式I化合物及其二硫化物及其盐是用于制备具有式III的杀微生物和植物免疫作用的化合物的重要中间产物：在式I和III化合物中：X为卤素，n为0 ，1,2或3; Z是CN，CO-A或CS-A，A是氢，卤素，OR1，SR2和N（R3）R4; R1至R4是氢，含有不多于8个碳原子的取代或未取代的开链，饱和或不饱和烃基，取代或未取代的环状，含不多于10个碳原子的饱和或不饱和烃基，取代或未取代的 苄基或苯乙基，取代或未取代的含不多于8个碳原子的烷酰基，取代或未取代的苯甲酰基或取代或未取代的杂环基; 或者R 3和R 4与它们所键合的氮原子一起为具有1-3个O，S和/或N杂原子的5或6元取代或未取代的杂环基团。制备 描述公式I.