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公开(公告)号：EP4324518A3
公开(公告)日：2024-05-22
申请号：EP23203095.7
申请日：2015-01-30
发明人： SABATOS-PEYTON, Catherine, Anne , BRANNETTI, Barbara , HARRIS, Alan, S. , HUBER, Thomas , PIETZONKA, Thomas , MATARAZA, Jennifer, Marie , BLATTLER, Walter, A. , HICKLIN, Daniel, J. , VASQUEZ, Maximiliano , DEKRUYFF, Rosemarie, H. , UMETSU, Dale, T. , FREEMAN, Gordon, James , HU, Tiancen , TARASZKA, John, A. , XU, Fangmin
IPC分类号： C07K16/28 , A61K39/395 , G01N33/68 , A61P1/04 , A61P1/16 , A61P1/18 , A61P7/00 , A61P11/00 , A61P13/08 , A61P15/00 , A61P17/00 , A61P25/00 , A61P31/00 , G01N33/574 , A61P13/12 , A61P35/00 , A61P37/02 , A61P35/02 , A61P35/04 , A61P37/04
CPC分类号： C07K2299/0020130101 , C07K2317/3420130101 , C07K2317/7620130101 , C07K2317/9420130101 , A61K39/395 , G01N33/57492 , G01N2333/7059620130101 , C07K16/2803 , C07K2317/2420130101 , A61P1/04 , A61P1/16 , A61P1/18 , A61P11/00 , A61P13/08 , A61P13/12 , A61P15/00 , A61P17/00 , A61P25/00 , A61P31/00 , A61P35/00 , A61P35/02 , A61P35/04 , A61P37/02 , A61P37/04 , A61P7/00 , Y02A50/30 , C07K2317/9220130101
摘要： Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.
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公开(公告)号：EP3099717B1
公开(公告)日：2019-03-27
申请号：EP15705163.2
申请日：2015-01-30
发明人： SABATOS-PEYTON, Catherine, Anne , BRANNETTI, Barbara , HARRIS, Alan, S. , HUBER, Thomas , PIETZONKA, Thomas , MATARAZA, Jennifer, Marie , BLATTLER, Walter, A. , HICKLIN, Daniel, J. , VASQUEZ, Maximiliano , DEKRUYFF, Rosemarie, H. , UMETSU, Dale, T. , FREEMAN, Gordon, James , HU, Tiancen , TARASZKA, John, A. , XU, Fangmin
IPC分类号： C07K16/28 , A61K39/395 , A61K45/06 , G01N33/68
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公开(公告)号：EP4324518A2
公开(公告)日：2024-02-21
申请号：EP23203095.7
申请日：2015-01-30
发明人： SABATOS-PEYTON, Catherine, Anne , BRANNETTI, Barbara , HARRIS, Alan, S. , HUBER, Thomas , PIETZONKA, Thomas , MATARAZA, Jennifer, Marie , BLATTLER, Walter, A. , HICKLIN, Daniel, J. , VASQUEZ, Maximiliano , DEKRUYFF, Rosemarie, H. , UMETSU, Dale, T. , FREEMAN, Gordon, James , HU, Tiancen , TARASZKA, John, A. , XU, Fangmin
IPC分类号： A61P1/18
摘要： Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.
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公开(公告)号：EP3878465A1
公开(公告)日：2021-09-15
申请号：EP21152298.2
申请日：2016-07-28
发明人： DRANOFF, Glenn , SABATOS-PEYTON, Catherine, Anne , BRANNETTI, Barbara , HARRIS, Alan, S. , HUBER, Thomas , PIETZONKA, Thomas , MATARAZA, Jennifer, Marie , BLATTLER, Walter, A. , HICKLIN, Daniel, J. , VASQUEZ, Maximiliano , DEKRUYFF, Rosemarie, H. , UMETSU, Dale, T. , FREEMAN, Gordon, James , HU, Tiancen , TARASZKA, John, A. , XU, Fangmin
摘要： Combination therapies comprising antibody molecules that specifically bind to TIM-3 are disclosed. The combination therapies can be used to treat or prevent cancerous or infectious conditions and disorders.
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公开(公告)号：EP3316902A1
公开(公告)日：2018-05-09
申请号：EP16750331.7
申请日：2016-07-28
发明人： DRANOFF, Glenn , SABATOS-PEYTON, Catherine, Anne , BRANNETTI, Barbara , HARRIS, Alan, S. , HUBER, Thomas , PIETZONKA, Thomas , MATARAZA, Jennifer, Marie , BLATTLER, Walter, A. , HICKLIN, Daniel, J. , VASQUEZ, Maximiliano , DEKRUYFF, Rosemarie, H. , UMETSU, Dale, T. , FREEMAN, Gordon, James , HU, Tiancen , TARASZKA, John, A. , XU, Fangmin
CPC分类号： A61K39/39566 , A61K39/00 , A61K39/3955 , A61K45/06 , A61K2039/507 , A61P35/00 , C07K16/2803 , C07K2299/00 , C07K2317/24 , C07K2317/34 , C07K2317/76 , C07K2317/94 , A61K2300/00
摘要： Combination therapies comprising antibody molecules that specifically bind to TIM-3 are disclosed. The combination therapies can be used to treat or prevent cancerous or infectious conditions and disorders.
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6.发明公开ANTIBODY MOLECULES TO TIM-3 AND USES THEREOF 审中-公开ANTIKÖRPERMOLEKÜLEMIT TIM-3 UND VERWENDUNGEN DAVON
公开(公告)号：EP3099717A1
公开(公告)日：2016-12-07
申请号：EP15705163.2
申请日：2015-01-30
发明人： SABATOS-PEYTON, Catherine, Anne , BRANNETTI, Barbara , HARRIS, Alan, S. , HUBER, Thomas , PIETZONKA, Thomas , MATARAZA, Jennifer, Marie , BLATTLER, Walter, A. , HICKLIN, Daniel, J. , VASQUEZ, Maximiliano , DEKRUYFF, Rosemarie, H. , UMETSU, Dale, T. , FREEMAN, Gordon, James , HU, Tiancen , TARASZKA, John, A. , XU, Fangmin
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K39/3955 , A61K39/39558 , A61K45/06 , C07K2299/00 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/6893
摘要： Antibody molecules that specifically bind to TIM-3 are disclosed. The anti-TIM-3 antibody molecules can be used to treat, prevent and/or diagnose immune, cancerous, or infectious conditions and/or disorders.
摘要翻译： 公开了特异性结合TIM-3的抗体分子。 抗TIM-3抗体分子可用于治疗，预防和/或诊断免疫，癌性或感染性疾病和/或病症。
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公开(公告)号：EP2935320B1
公开(公告)日：2019-08-21
申请号：EP13828987.1
申请日：2013-12-16
申请人： Novartis AG
发明人： FORNARO, Mara , HUBER, Thomas , ZURINI, Mauro
IPC分类号： C07K14/65
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公开(公告)号：EP3514178A1
公开(公告)日：2019-07-24
申请号：EP18188339.8
申请日：2014-03-12
申请人： Novartis AG
发明人： ABRAMS, Tinya , COHEN, Steven , FANTON, Christie P. , HUBER, Thomas , MILLER, Kathy , SCHLEYER, Siew Ho , TISSOT-DAGUETTE, Kathrin Ulrike , FINNER, Catrin
摘要： The present invention relates to anti-cKIT antibodies, antibody fragments, antibody drug conjugates, and their uses for the treatment of cancer.
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公开(公告)号：EP3218410A1
公开(公告)日：2017-09-20
申请号：EP15798251.3
申请日：2015-11-13
申请人： Novartis AG
发明人： ABRAMS, Tinya , COHEN, Steven , DAMIANO, Jason , DÜRR, Clemens , HUBER, Thomas , MENEZES, Daniel , MILLER, Kathy , RENDAHL, Katherine , RONDEAU, Jean-michel Rene
CPC分类号： C07K16/28 , A61K31/5365 , A61K47/6803 , A61K47/6849 , A61K47/6851 , C07K16/30 , C07K2299/00 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2319/00 , G01N33/57492 , G01N2333/705
摘要： This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.
摘要翻译： 该申请公开了抗P-钙粘蛋白抗体，其抗原结合片段和所述抗体或抗原结合片段的抗体药物缀合物。 本发明还涉及使用抗体，抗原结合片段和抗体药物缀合物治疗癌症的方法。 本文还公开了制备抗体，抗原结合片段和抗体药物缀合物的方法，以及使用所述抗体和抗原结合片段作为诊断试剂的方法。
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10.发明公开
公开(公告)号：EP4450086A2
公开(公告)日：2024-10-23
申请号：EP24189245.4
申请日：2014-02-07
申请人： Novartis AG
IPC分类号： A61K39/395
摘要： The present disclosure relates to antibodies and proteins comprising an antigen-binding portion thereof that specifically bind to the pro-inflammatory cytokine IL-17A. The disclosure more specifically relates to specific antibodies and proteins that are IL-17A antagonists (inhibit the activities of IL-17A and IL-17AF) and are capable of inhibiting IL-17A induced cytokine production in in vitro assays, and having an inhibitory effect in an antigen-induced arthritis model in vivo. The disclosure further relates to compositions and methods of use for said antibodies and proteins to treat pathological disorders that can be treated by inhibiting IL-17A or IL17AF mediated activity, such as rheumatoid arthritis, psoriasis, systemic lupus erythematosus (SLE), lupus nephritis, chronic obstructive pulmonary disease, asthma or cystic fibrosis or other autoimmune and inflammatory disorders.
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