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公开(公告)号：EP2651396B1
公开(公告)日：2017-07-12
申请号：EP11794739.0
申请日：2011-12-12
申请人： Novartis AG , Debiopharm S.A.
发明人： GONCALVES, Elisabete , RAPP, Karin , SUTTER, Bertrand , STOWASSER, Frank , TRUPP, Bjoern , CHABAUT, Sebastian , THORENS, Julien
CPC分类号： A61K38/13 , A61K9/0053 , A61K9/0095 , A61K9/107 , A61K9/1075 , A61K9/4858 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/26
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公开(公告)号：EP2651396A2
公开(公告)日：2013-10-23
申请号：EP11794739.0
申请日：2011-12-12
申请人： Novartis AG , Debiopharm S.A.
发明人： GONCALVES, Elisabete , RAPP, Karin , SUTTER, Bertrand , STOWASSER, Frank , TRUPP, Bjoern , CHABAUT, Sebastian , THORENS, Julien
CPC分类号： A61K38/13 , A61K9/0053 , A61K9/0095 , A61K9/107 , A61K9/1075 , A61K9/4858 , A61K47/10 , A61K47/14 , A61K47/22 , A61K47/26
摘要： The invention provides lipid-based pharmaceutical compositions comprising alisporivir.
摘要翻译： 本发明提供了基于脂质的药物组合物，包括阿拉泊韦。
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3.发明授权SALTS OF AZA-BICYCLIC DI-ARYL ETHERS AND METHODS TO MAKE THEM OR THEIR PRECURSORS 有权AZA-DI双环芳基醚和盐生产或其前体PROCESS FOR
公开(公告)号：EP2731946B1
公开(公告)日：2016-09-14
申请号：EP12735521.2
申请日：2012-07-12
申请人： Novartis AG
发明人： MARTERER, Wolfgang , PRASHAD, Mahavir , VILLHAUER, Edwin Bernard , WAYKOLE, Liladhar Murlidhar , VIVELO, James Anthony , SUTTER, Bertrand , BIANCHI, Jean-Claude , WU, Raeann , HAR, Denis , KARPINSKI, Piotr H. , PIGNONE, Massimo , STINGELIN, Doris , BUERGER, Eckart
IPC分类号： C07D453/02 , A61K31/439 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28
CPC分类号： C07D453/02 , A61K9/2054 , A61K31/194 , A61K31/439 , A61K2300/00 , C07B2200/07 , C07B2200/13 , C07C51/412 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15
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4.发明公开CRYSTAL MODIFICATION OF A N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVE, PROCESSES FOR ITS MANUFACTURE AND ITS USE 失效N-苯基-2-嘧啶胺衍生物的晶体改性，其制备方法及其用途
公开(公告)号：EP0998473A1
公开(公告)日：2000-05-10
申请号：EP98941342.2
申请日：1998-07-16
IPC分类号： C07D401/04 , A61K31/505
CPC分类号： C07D401/04 , C30B7/00
摘要： The invention relates to a new crystalline form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of formula (I), which may be used for example for tumour therapy.
摘要翻译： 本发明涉及4-（4-甲基哌嗪-1-基甲基）-N- [4-甲基-3-（4-吡啶-3-基）嘧啶-2-基氨基]甲烷磺酸加成盐的新结晶形式 ）苯基] - 苯甲酰胺，其可以用于例如肿瘤治疗。
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5.发明公开SALTS OF AZA-BICYCLIC DI-ARYL ETHERS AND METHODS TO MAKE THEM OR THEIR PRECURSORS 有权AZA-DI双环芳基醚和盐生产或其前体PROCESS FOR
公开(公告)号：EP2731946A1
公开(公告)日：2014-05-21
申请号：EP12735521.2
申请日：2012-07-12
申请人： Novartis AG
发明人： MARTERER, Wolfgang , PRASHAD, Mahavir , VILLHAUER, Edwin Bernard , WAYKOLE, Liladhar Murlidhar , VIVELO, James Anthony , SUTTER, Bertrand , BIANCHI, Jean-Claude , WU, Raeann , HAR, Denis , KARPINSKI, Piotr H. , PIGNONE, Massimo , STINGELIN, Doris , BUERGER, Eckart
IPC分类号： C07D453/02 , A61K31/439 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28
CPC分类号： C07D453/02 , A61K9/2054 , A61K31/194 , A61K31/439 , A61K2300/00 , C07B2200/07 , C07B2200/13 , C07C51/412 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15
摘要： The present invention relates to salts of (R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza- bicyclo[2.2.2]octane, to methods for making them or their precursors, to pharmaceutical compositions comprising them, and to their use as medicaments.
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6.发明公开PROCESS FOR THE PREPARATION OF (R)-3-(6-(4-METHYLPHENYL)-PYRIDIN-3-YLOXY)-1-AZA-BICYCLO[2.2.2]OCTANE AND PROCESS FOR THE PREPARATION OF THE INTERMEDIATE 5-CHLORO-2-(4-METHYLPHENYL)PYRIDINE 审中-公开PROCESS FOR的（R）-3-（6-（4-甲基苯基）吡啶-3-基氧基）FOR中间体的制备5-氯-2- -1-氮杂双环[2.2.2]辛烷和方法制备（ 4-甲基苯基）吡啶
公开(公告)号：EP3075732A3
公开(公告)日：2017-01-04
申请号：EP16162555.3
申请日：2012-07-12
申请人： Novartis AG
发明人： MARTERER, Wolfgang , PRASHAD, Mahavir , VILLHAUER, Edwin Bernard , WAYKOLE, Liladhar Murlidhar , VIVELO, James Anthony , SUTTER, Bertrand , BIANCHI, Jean-Claude , WU, Raeann , HAR, Denis , KARPINSKI, Piotr H. , PIGNONE, Massimo , STINGELIN, Doris , BUERGER, Eckart
IPC分类号： C07D453/02 , A61K31/439 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28
CPC分类号： C07D453/02 , A61K9/2054 , A61K31/194 , A61K31/439 , A61K2300/00 , C07B2200/07 , C07B2200/13 , C07C51/412 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15
摘要： The present invention relates to a process for the production of a compound of formula I ((R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane) or a salt thereof and to a process for the production of a compound of formula II (5-chloro-2-(4-methylphenyl)pyridine ) or a salt thereof, which is used as an intermediate in the preparation of the compound of formula I.
摘要翻译： 本发明涉及一种用于生产式I（（R）-3-（6-（4-甲基苯基）吡啶-3-基氧基）-1-氮杂双环[2.2.2]辛烷的化合物的 ）或其盐和用于生产式II的化合物的方法（5-氯-2-（4-甲基 - 苯基）吡啶）或其它用作在中间在的化合物的制备的盐，所有 式I
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7.发明授权CRYSTAL MODIFICATION OF A N-PHENYL-2-PYRIMIDINEAMINE DERIVATIVE, PROCESSES FOR ITS MANUFACTURE AND ITS USE 失效晶体变阿H-苯基-2-嘧啶胺衍生物，其制备方法及其用途
公开(公告)号：EP0998473B1
公开(公告)日：2003-10-01
申请号：EP98941342.2
申请日：1998-07-16
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07D401/04 , A61K31/505
CPC分类号： C07D401/04 , C30B7/00
摘要： The invention relates to a new crystalline form of the methanesulfonic acid addition salt of 4-(4-methylpiperazin-1-ylmethyl)-N-[4-methyl-3-(4-pyridin-3-yl)pyrimidin-2-ylamino)phenyl]-benzamide of formula (I), which may be used for example for tumour therapy.
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公开(公告)号：EP3075732B1
公开(公告)日：2018-09-12
申请号：EP16162555.3
申请日：2012-07-12
申请人： Novartis AG
发明人： MARTERER, Wolfgang , PRASHAD, Mahavir , VILLHAUER, Edwin Bernard , WAYKOLE, Liladhar Murlidhar , VIVELO, James Anthony , SUTTER, Bertrand , BIANCHI, Jean-Claude , WU, Raeann , HAR, Denis , KARPINSKI, Piotr H. , PIGNONE, Massimo , STINGELIN, Doris , BUERGER, Eckart
IPC分类号： C07D453/02 , A61K31/439 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28
CPC分类号： C07D453/02 , A61K9/2054 , A61K31/194 , A61K31/439 , A61K2300/00 , C07B2200/07 , C07B2200/13 , C07C51/412 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15
摘要： The present invention relates to a process for the production of a compound of formula I ((R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane) or a salt thereof and to a process for the production of a compound of formula II (5-chloro-2-(4-methylphenyl)pyridine ) or a salt thereof, which is used as an intermediate in the preparation of the compound of formula I.
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9.发明公开PROCESS FOR THE PREPARATION OF (R)-3-(6-(4-METHYLPHENYL)-PYRIDIN-3-YLOXY)-1-AZA-BICYCLO[2.2.2]OCTANE AND PROCESS FOR THE PREPARATION OF THE INTERMEDIATE 5-CHLORO-2-(4-METHYLPHENYL)PYRIDINE 审中-公开PROCESS FOR的（R）-3-（6-（4-甲基苯基）吡啶-3-基氧基）FOR中间体的制备5-氯-2- -1-氮杂双环[2.2.2]辛烷和方法制备（ 4-甲基苯基）吡啶
公开(公告)号：EP3075732A2
公开(公告)日：2016-10-05
申请号：EP16162555.3
申请日：2012-07-12
申请人： Novartis AG
发明人： MARTERER, Wolfgang , PRASHAD, Mahavir , VILLHAUER, Edwin Bernard , WAYKOLE, Liladhar Murlidhar , VIVELO, James Anthony , SUTTER, Bertrand , BIANCHI, Jean-Claude , WU, Raeann , HAR, Denis , KARPINSKI, Piotr H. , PIGNONE, Massimo , STINGELIN, Doris , BUERGER, Eckart
IPC分类号： C07D453/02 , A61K31/439 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28
CPC分类号： C07D453/02 , A61K9/2054 , A61K31/194 , A61K31/439 , A61K2300/00 , C07B2200/07 , C07B2200/13 , C07C51/412 , C07C55/08 , C07C55/10 , C07C57/145 , C07C57/15
摘要： The present invention relates to a process for the production of a compound of formula I ((R)-3-(6-(4-methylphenyl)-pyridin-3-yloxy)-1-aza-bicyclo[2.2.2]octane) or a salt thereof and to a process for the production of a compound of formula II (5-chloro-2-(4-methylphenyl)pyridine ) or a salt thereof, which is used as an intermediate in the preparation of the compound of formula I.
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