公开(公告)号：EP1828172A1

公开(公告)日：2007-09-05

申请号：EP05815747.0

申请日：2005-12-12

申请人： Novartis AG ,  NOVARTIS-PHARMA GMBH

发明人： ADCOCK, Claire ,  LEBLANC, Catherine ,  SANDHAM, David Andrew ,  WATSON, Simon James ,  BALA, Kamlesh Jagdis

IPC分类号： C07D407/04 ,  C07D401/04 ,  C07D207/34 ,  A61K31/40 ,  A61K31/4439 ,  A61P11/00

CPC分类号： C07D401/06 ,  C07D207/34 ,  C07D405/04

摘要： There are provided according to the invention compounds of formula (I) as CRTh2 antagonists. In free or salt form, wherein R3, R4, R5, R6, Q, W and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.

公开(公告)号：EP1809648A2

公开(公告)日：2007-07-25

申请号：EP05763604.5

申请日：2005-07-13

申请人： Novartis AG ,  NOVARTIS-PHARMA GMBH

发明人： SANDHAM, David Andrew ,  SHARP, Christopher William ,  WATSON, Simon, James

IPC分类号： C07J1/00

CPC分类号： C07J1/00

摘要： Compounds of formula (I) in free or salt form, wherein R1 and R2 have the meanings as indicated in the specification, are useful for treating inflammatory conditions, particularly inflammatory or obstructive airways disease. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.

公开(公告)号：EP1828172B1

公开(公告)日：2009-11-25

申请号：EP05815747.0

申请日：2005-12-12

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： ADCOCK, Claire ,  LEBLANC, Catherine ,  SANDHAM, David Andrew ,  WATSON, Simon James ,  BALA, Kamlesh Jagdis

IPC分类号： C07D407/04 ,  C07D401/04 ,  C07D207/34 ,  A61K31/40 ,  A61K31/4439 ,  A61P11/00

CPC分类号： C07D401/06 ,  C07D207/34 ,  C07D405/04

摘要： There are provided according to the invention compounds of formula (I) as CRTh2 antagonists. In free or salt form, wherein R3, R4, R5, R6, Q, W and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.

公开(公告)号：EP1891029B1

公开(公告)日：2010-01-06

申请号：EP06753784.5

申请日：2006-05-22

申请人： Novartis AG

发明人： AXFORD, Jake ,  BAETTIG, Urs ,  COX, Brian ,  BALA, Kamlesh Jagdis ,  LEBLANC, Catherine ,  SANDHAM, David Andrew

IPC分类号： C07D295/16 ,  A61K31/40 ,  A61K31/445 ,  A61P29/00

CPC分类号： C07D295/185

摘要： Compounds of formula (I) in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, R6, R7, m, n, w, X, and Y have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 receptor, especially inflammatory or obstructive airways diseases.

公开(公告)号：EP1891029A1

公开(公告)日：2008-02-27

申请号：EP06753784.5

申请日：2006-05-22

申请人： Novartis AG

发明人： AXFORD, Jake ,  BAETTIG, Urs ,  COX, Brian ,  BALA, Kamlesh Jagdis ,  LEBLANC, Catherine ,  SANDHAM, David Andrew

IPC分类号： C07D295/16 ,  A61K31/40 ,  A61K31/445 ,  A61P29/00

CPC分类号： C07D295/185

摘要： Compounds of formula (I) in free or pharmaceutically acceptable salt form, where R1, R2, R3, R4, R5, R6, R7, m, n, w, X, and Y have the meanings as indicated in the specification, are useful for treating conditions mediated by the CRTh2 receptor, especially inflammatory or obstructive airways diseases.

公开(公告)号：EP2771342B1

公开(公告)日：2016-05-18

申请号：EP12798854.1

申请日：2012-10-26

申请人： Novartis AG

发明人： BRIARD, Emmanuelle ,  FURET, Pascal ,  LERCHNER, Andreas ,  MEIER, Peter ,  RADETICH, Branko ,  SANDHAM, David Andrew ,  ZHU, Yanyi

IPC分类号： C07D473/16 ,  C07D519/00

CPC分类号： C07D473/16 ,  A61K31/5377 ,  A61K31/553 ,  C07D487/04 ,  C07D491/048 ,  C07D491/107 ,  C07D519/00

公开(公告)号：EP2771342A1

公开(公告)日：2014-09-03

申请号：EP12798854.1

申请日：2012-10-26

申请人： Novartis AG

发明人： BRIARD, Emmanuelle ,  FURET, Pascal ,  LERCHNER, Andreas ,  MEIER, Peter ,  RADETICH, Branko ,  SANDHAM, David Andrew ,  ZHU, Yanyi

IPC分类号： C07D473/16 ,  C07D519/00

CPC分类号： C07D473/16 ,  A61K31/5377 ,  A61K31/553 ,  C07D487/04 ,  C07D491/048 ,  C07D491/107 ,  C07D519/00

摘要： The invention relates to PI3K inhibitors of the formula (I) • in which all of the variables are as defined in the specification, to their preparation, to their medical use, in particular to their use in the treatment of cancer and neurodegenerative disorders, and to medicaments comprising them.

公开(公告)号：EP4196478A1

公开(公告)日：2023-06-21

申请号：EP21755587.9

申请日：2021-08-12

申请人： Novartis AG

发明人： BUSHABOINA, Mallesh ,  CHEN, Xin ,  CHEUNG, Atwood Kim ,  CULSHAW, Andrew James ,  HURLEY, Timothy Brian ,  LABBE-GIGUERE, Nancy ,  MILTZ, Wolfgang ,  ORAIN, David ,  PATEL, Tajesh ,  RAJAGOPALAN, Srinivasan ,  ROEHN, Till ,  SANDHAM, David Andrew ,  THOMA, Gebhard ,  TICHKULE, Ritesh Bhanudasji ,  WÄLCHLI, Rudolf

IPC分类号： C07D471/10 ,  C07D491/10 ,  C07D498/10 ,  C07D519/00 ,  A61P11/06 ,  A61P37/08 ,  A61K31/4747

公开(公告)号：EP3022201A1

公开(公告)日：2016-05-25

申请号：EP14766209.2

申请日：2014-07-16

申请人： Novartis AG

发明人： BAETTIG, Urs ,  BEATTIE, David ,  LEGRAND, Darren Mark ,  LISTER, Andrew Stuart ,  MCKENNA, Jeffrey ,  PEARCE, David William ,  SANDHAM, David Andrew ,  STANLEY, Emily ,  STEWARD, Oliver Ross ,  THOMSON, Christopher

IPC分类号： C07D403/12 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  C07D257/04 ,  A61K31/41 ,  A61P35/00

CPC分类号： C07D401/12 ,  A61K45/06 ,  C07D257/04 ,  C07D403/12 ,  C07D405/12 ,  C07D407/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention relates to novel compounds that are autotaxin inhibitors, processes for their preparation, pharmaceutical compositions and medicaments containing them and to their use in diseases and disorders mediated by autotaxin.

摘要翻译： 本发明涉及自体贴剂抑制剂的新型化合物，其制备方法，药物组合物和含有它们的药物及其在自体吸收素介导的疾病和病症中的用途。

公开(公告)号：EP1963322B1

公开(公告)日：2013-08-21

申请号：EP06841297.2

申请日：2006-12-07

申请人： Novartis AG

发明人： SANDHAM, David Andrew ,  LEBLANC, Catherine ,  BROWN, Lyndon Nigel

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P29/00

CPC分类号： C07D471/04