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公开(公告)号：EP2032555A1
公开(公告)日：2009-03-11
申请号：EP07764611.5
申请日：2007-06-11
申请人： NOVARTIS AG , Novartis Pharma GmbH
发明人： SANDHAM, David, Andrew , LEBLANC, Catherine , ADCOCK, Claire , BALA, Kamlesh, Jagdis , PIPET, Maude, Nadine, Pierrette
IPC分类号： C07D401/12 , A61K31/40 , A61P11/00 , A61P29/00
CPC分类号： C07D401/12
摘要： There are provided according to the invention compounds of formula (I) in free or salt form, wherein R3, R 4, R5, R6a, R6b, Q and W are as described in the specification, process for preparing them, and their use as pharmaceuticals.
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公开(公告)号：EP1480962A1
公开(公告)日：2004-12-01
申请号：EP03709730.0
申请日：2003-02-27
申请人： Novartis AG , Novartis Pharma GmbH
发明人： BRUCE, Ian , FINAN, Peter , LEBLANC, Catherine , MCCARTHY, Clive , WHITEHEAD, Lewis , PRESS, Nicola, Elaine , BLOOMFIELD, Graham, Charles , HAYLER, Judy , KIRMAN, Louise , OZA, Mrinalini, Sachin , SHUKLA, Lena
IPC分类号： C07D277/46 , C07D277/48 , C07D417/12 , C07D417/10 , A61K31/426 , A61K31/427 , A61P11/00 , A61P37/08 , A61P19/02 , A61P35/00 , A61P17/06 , A61P37/06 , A61P3/04 , A61P9/10
CPC分类号： C07D277/40 , C07D277/46 , C07D277/48 , C07D417/04 , C07D417/12
摘要： Compounds of Formula I in free or salt form, wherein R1,R2,R3,R4, and R5, have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
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公开(公告)号：EP1828172A1
公开(公告)日：2007-09-05
申请号：EP05815747.0
申请日：2005-12-12
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
发明人： ADCOCK, Claire , LEBLANC, Catherine , SANDHAM, David Andrew , WATSON, Simon James , BALA, Kamlesh Jagdis
IPC分类号： C07D407/04 , C07D401/04 , C07D207/34 , A61K31/40 , A61K31/4439 , A61P11/00
CPC分类号： C07D401/06 , C07D207/34 , C07D405/04
摘要： There are provided according to the invention compounds of formula (I) as CRTh2 antagonists. In free or salt form, wherein R3, R4, R5, R6, Q, W and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
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公开(公告)号：EP1828172B1
公开(公告)日：2009-11-25
申请号：EP05815747.0
申请日：2005-12-12
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ADCOCK, Claire , LEBLANC, Catherine , SANDHAM, David Andrew , WATSON, Simon James , BALA, Kamlesh Jagdis
IPC分类号： C07D407/04 , C07D401/04 , C07D207/34 , A61K31/40 , A61K31/4439 , A61P11/00
CPC分类号： C07D401/06 , C07D207/34 , C07D405/04
摘要： There are provided according to the invention compounds of formula (I) as CRTh2 antagonists. In free or salt form, wherein R3, R4, R5, R6, Q, W and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
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公开(公告)号：EP3200786B1
公开(公告)日：2019-08-28
申请号：EP15781518.4
申请日：2015-10-02
申请人： Novartis AG
发明人： FAIRHURST, Robin, Alec , FURET, Pascal , KNÖPFEL, Thomas , LEBLANC, Catherine , LIAO, Lv , MAH, Robert , NIMSGERN, Pierre , RIPOCHE, Sebastien , XIONG, Jing , ZHAO, Xianglin , HAN, Bo , WANG, Can , PORTER, Dale , BUSCHMANN, Nicole , GRAUS PORTA, Diana , HAEFLIGER, Carolina , MURAKAMI, Masato , PALMER, Michael , WANG, Youzhen , WEISS, Andreas
IPC分类号： A61K31/4375 , A61K31/437 , A61K31/4353 , A61K31/506 , A61K31/5383 , A61K31/5377 , A61K31/501 , A61P35/00
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公开(公告)号：EP2956455B1
公开(公告)日：2017-05-17
申请号：EP14707841.4
申请日：2014-02-11
申请人： Novartis AG
IPC分类号： C07D471/04 , A61K31/4375 , A61P7/02 , A61P9/10 , A61P11/06 , A61P3/10 , A61P29/00 , A61P19/04
CPC分类号： C07D471/04 , A61K31/4375
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公开(公告)号：EP2802584B1
公开(公告)日：2015-11-18
申请号：EP13707037.1
申请日：2013-01-11
申请人： Novartis AG
IPC分类号： C07D471/04 , A61K31/4985 , A61P9/00 , A61P11/00
CPC分类号： C07D471/04
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公开(公告)号：EP2231642B1
公开(公告)日：2013-10-23
申请号：EP09700452.7
申请日：2009-01-09
申请人： Novartis AG
IPC分类号： C07D401/14 , A61K31/506 , A61P19/10
CPC分类号： C07D401/14
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公开(公告)号：EP1963322A1
公开(公告)日：2008-09-03
申请号：EP06841297.2
申请日：2006-12-07
申请人： Novartis AG
IPC分类号： C07D471/04 , A61K31/437 , A61P29/00
CPC分类号： C07D471/04
摘要： There are provided according to the invention compounds of formula (I) in free or salt form, wherein R1, R2, R4, R5, R6, A, D, X, W, m and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
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公开(公告)号：EP4344702A3
公开(公告)日：2024-04-10
申请号：EP24151713.5
申请日：2020-12-17
申请人： Novartis AG
发明人： COTESTA, Simona , GERSPACHER, Marc , LEBLANC, Catherine , LIU, Bo , LORTHIOIS, Edwige Liliane Jeanne , MACHAUER, Rainer , MAH, Robert , MURA, Christophe , RIGOLLIER, Pascal , SCHNEIDER, Nadine , STUTZ, Stefan , VAUPEL, Andrea , WARIN, Nicolas , WILCKEN, Rainer
IPC分类号： A61P35/00 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , A61K31/416
摘要： The present invention provides a compound of formula (I) or a stereoisomer thereof, or an atropisomer thereof, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt of a stereoisomer thereof, or a pharmaceutically acceptable salt of an atropisomer thereof;
a method for manufacturing said compound, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition comprising said compound.
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