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公开(公告)号：EP1828172B1
公开(公告)日：2009-11-25
申请号：EP05815747.0
申请日：2005-12-12
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ADCOCK, Claire , LEBLANC, Catherine , SANDHAM, David Andrew , WATSON, Simon James , BALA, Kamlesh Jagdis
IPC分类号： C07D407/04 , C07D401/04 , C07D207/34 , A61K31/40 , A61K31/4439 , A61P11/00
CPC分类号： C07D401/06 , C07D207/34 , C07D405/04
摘要： There are provided according to the invention compounds of formula (I) as CRTh2 antagonists. In free or salt form, wherein R3, R4, R5, R6, Q, W and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
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公开(公告)号：EP1828172A1
公开(公告)日：2007-09-05
申请号：EP05815747.0
申请日：2005-12-12
申请人： Novartis AG , NOVARTIS-PHARMA GMBH
发明人： ADCOCK, Claire , LEBLANC, Catherine , SANDHAM, David Andrew , WATSON, Simon James , BALA, Kamlesh Jagdis
IPC分类号： C07D407/04 , C07D401/04 , C07D207/34 , A61K31/40 , A61K31/4439 , A61P11/00
CPC分类号： C07D401/06 , C07D207/34 , C07D405/04
摘要： There are provided according to the invention compounds of formula (I) as CRTh2 antagonists. In free or salt form, wherein R3, R4, R5, R6, Q, W and n are as described in the specification, process for preparing them, and their use as pharmaceuticals.
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公开(公告)号：EP2257552A1
公开(公告)日：2010-12-08
申请号：EP09714437.2
申请日：2009-02-25
申请人： Novartis AG
IPC分类号： C07D487/04 , A61K31/519 , A61P37/06
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I) wherein R
1 , R
2 , X, Y and Z are as defined in the specification.-
公开(公告)号：EP3134397A1
公开(公告)日：2017-03-01
申请号：EP14726415.4
申请日：2014-04-24
申请人： Novartis AG
发明人： BELLENIE, Benjamin Richard , BLOOMFIELD, Graham Charles , BRUCE, Ian , CULSHAW, Andrew James , HALL, Edward Charles , HOLLINGWORTH, Gregory , NEEF, James , SPENDIFF, Matthew , WATSON, Simon James
IPC分类号： C07D401/14 , C07D405/14 , C07D401/04 , C07D403/04 , C07D403/14 , C07D409/04 , C07D413/04 , C07D417/04 , C07D417/14
CPC分类号： A61K31/497 , A61K31/5377 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , C07D405/04 , C07D405/14 , C07D409/04 , C07D409/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
摘要翻译： 本发明提供抑制PI3-激酶γ同种型活性的式（I）化合物，其可用于治疗PI3激酶γ同种型的激活介导的疾病。
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公开(公告)号：EP3134396A1
公开(公告)日：2017-03-01
申请号：EP14726414.7
申请日：2014-04-24
申请人： Novartis AG
发明人： BELLENIE, Benjamin Richard , BLOOMFIELD, Graham Charles , BRUCE, Ian , CULSHAW, Andrew James , HALL, Edward Charles , HOLLINGWORTH, Gregory , NEEF, James , SPENDIFF, Matthew , WATSON, Simon James
IPC分类号： C07D401/14 , C07D413/14 , C07D213/73 , C07D401/04 , C07D413/04 , C07D417/04 , C07D491/107 , A61K31/4439 , A61P11/06
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
摘要翻译： 本发明提供抑制PI3-激酶γ同种型活性的式（I）化合物，其可用于治疗PI3激酶γ同种型的激活介导的疾病。
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6.发明授权
公开(公告)号：EP2155670B1
公开(公告)日：2012-04-18
申请号：EP08760484.9
申请日：2008-06-04
申请人： Novartis AG
IPC分类号： C07D207/09 , C07D307/14 , A61K31/341
CPC分类号： C07D207/09 , C07D307/14
摘要： The present invention relates to compounds of formula (I) with the substituents as defined herein, and uses thereof.
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公开(公告)号：EP3134395B1
公开(公告)日：2018-01-31
申请号：EP14726416.2
申请日：2014-04-24
申请人： Novartis AG
发明人： BELLENIE, Benjamin Richard , BRUCE, Ian , CULSHAW, Andrew James , HOLLINGWORTH, Gregory , NEEF, James , SPENDIFF, Matthew , WATSON, Simon James
IPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , C07D409/04 , C07D417/04 , A61K31/497 , A61P17/00 , A61P35/00 , A61P37/00
CPC分类号： C07D417/04 , A61K31/497 , A61K31/5377 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
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公开(公告)号：EP2310359B1
公开(公告)日：2014-01-15
申请号：EP09804555.2
申请日：2009-08-03
申请人： Novartis AG
IPC分类号： C07C311/48 , C07D213/38 , C07D231/12 , C07D241/12 , C07D307/14 , C07D307/42 , C07D333/36 , C07D413/12 , A61K31/18 , A61P29/00
CPC分类号： C07D213/52 , C07C311/48 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D213/38 , C07D231/12 , C07D241/12 , C07D307/14 , C07D307/42 , C07D307/52 , C07D333/36 , C07D413/12
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9.发明公开5-SULFANYLMETHYL-PYRAZOLO [1,5-A]PYRIMIDIN-7-OL DERIVATIVES AS CXCR2 ANTAGONISTS 审中-公开作为CXCR2拮抗剂的5-磺基甲基 - 吡唑并[1,5-A]嘧啶-7-醇衍生物
公开(公告)号：EP2094697A1
公开(公告)日：2009-09-02
申请号：EP07822797.2
申请日：2007-11-21
申请人： NOVARTIS AG
IPC分类号： C07D471/04 , A61K31/522 , A61P29/00
CPC分类号： C07D471/04
摘要： The present invention relates to compounds of formula (I) and the use of these compounds as pharmaceuticals, e.g. in preventing or treating a CXCR2 receptor mediated condition or disease.
摘要翻译： 本发明涉及式（I）化合物和这些化合物作为药物的用途，例如， 用于预防或治疗CXCR2受体介导的病症或疾病。
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公开(公告)号：EP3134395A1
公开(公告)日：2017-03-01
申请号：EP14726416.2
申请日：2014-04-24
申请人： Novartis AG
发明人： BELLENIE, Benjamin Richard , BRUCE, Ian , CULSHAW, Andrew James , HOLLINGWORTH, Gregory , NEEF, James , SPENDIFF, Matthew , WATSON, Simon James
IPC分类号： C07D401/04 , C07D403/04 , C07D403/14 , C07D409/04 , C07D417/04 , A61K31/497 , A61P17/00 , A61P35/00 , A61P37/00
CPC分类号： C07D417/04 , A61K31/497 , A61K31/5377 , C07D401/04 , C07D403/04 , C07D403/14 , C07D405/14 , C07D409/04
摘要： The present invention provides compounds of formula (I) which inhibit the activity of PI 3-kinase gamma isoform, which are useful for the treatment of diseases mediated by the activation of PI 3-kinase gamma isoform.
摘要翻译： 本发明提供抑制PI3-激酶γ同种型活性的式（I）化合物，其可用于治疗PI3激酶γ同种型的激活介导的疾病。
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