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1.发明授权
公开(公告)号：EP1216226B1
公开(公告)日：2009-11-04
申请号：EP00969292.2
申请日：2000-09-25
申请人： Novartis AG , Novartis Pharma GmbH
发明人： ACEMOGLU, Murat , ALLMENDINGER, Thomas , CALIENNI, John, Vincent , CERCUS, Jacques , LOISELEUR, Olivier , SEDELMEIER, Gottfried , XU, David
IPC分类号： C07C229/42 , C07C227/22 , C07D209/34 , C07C233/15 , C07C235/24 , C07C235/16 , C07C211/56 , C07C211/52
CPC分类号： C07C211/52 , C07C211/56 , C07C227/22 , C07C229/42 , C07C233/15 , C07C235/16 , C07C235/24 , C07C2601/16 , C07D209/34
摘要： A process for the production of a compound of formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula (II) wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of formula (I) are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase (II).
摘要翻译： 一种制备式（I）化合物或其药学上可接受的盐或其药学上可接受的前药酯的方法，包括用碱定义其中符号如上定义的式（II）的内酰胺; 及其前体和制备前体的方法。 式（I）化合物是作为环氧合酶（II）的选择性抑制剂的药学活性化合物。
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公开(公告)号：EP1216226A2
公开(公告)日：2002-06-26
申请号：EP00969292.2
申请日：2000-09-25
发明人： ACEMOGLU, Murat , ALLMENDINGER, Thomas , CALIENNI, John, Vincent , CERCUS, Jacques , LOISELEUR, Olivier , SEDELMEIER, Gottfried , XU, David
IPC分类号： C07C229/42 , C07C227/22 , C07D209/34 , C07C233/15 , C07C235/24 , C07C235/16 , C07C211/56 , C07C211/52
CPC分类号： C07C211/52 , C07C211/56 , C07C227/22 , C07C229/42 , C07C233/15 , C07C235/16 , C07C235/24 , C07C2601/16 , C07D209/34
摘要： A process for the production of a compound of formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula (II) wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of formula (I) are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase (II).
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