公开(公告)号：EP1216226B1

公开(公告)日：2009-11-04

申请号：EP00969292.2

申请日：2000-09-25

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： ACEMOGLU, Murat ,  ALLMENDINGER, Thomas ,  CALIENNI, John, Vincent ,  CERCUS, Jacques ,  LOISELEUR, Olivier ,  SEDELMEIER, Gottfried ,  XU, David

IPC分类号： C07C229/42 ,  C07C227/22 ,  C07D209/34 ,  C07C233/15 ,  C07C235/24 ,  C07C235/16 ,  C07C211/56 ,  C07C211/52

CPC分类号： C07C211/52 ,  C07C211/56 ,  C07C227/22 ,  C07C229/42 ,  C07C233/15 ,  C07C235/16 ,  C07C235/24 ,  C07C2601/16 ,  C07D209/34

摘要： A process for the production of a compound of formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula (II) wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of formula (I) are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase (II).

摘要翻译： 一种制备式（I）化合物或其药学上可接受的盐或其药学上可接受的前药酯的方法，包括用碱定义其中符号如上定义的式（II）的内酰胺; 及其前体和制备前体的方法。 式（I）化合物是作为环氧合酶（II）的选择性抑制剂的药学活性化合物。

公开(公告)号：EP1216226A2

公开(公告)日：2002-06-26

申请号：EP00969292.2

申请日：2000-09-25

申请人： Novartis AG ,  Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

发明人： ACEMOGLU, Murat ,  ALLMENDINGER, Thomas ,  CALIENNI, John, Vincent ,  CERCUS, Jacques ,  LOISELEUR, Olivier ,  SEDELMEIER, Gottfried ,  XU, David

IPC分类号： C07C229/42 ,  C07C227/22 ,  C07D209/34 ,  C07C233/15 ,  C07C235/24 ,  C07C235/16 ,  C07C211/56 ,  C07C211/52

CPC分类号： C07C211/52 ,  C07C211/56 ,  C07C227/22 ,  C07C229/42 ,  C07C233/15 ,  C07C235/16 ,  C07C235/24 ,  C07C2601/16 ,  C07D209/34

摘要： A process for the production of a compound of formula (I), or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable prodrug ester thereof, comprising cleaving a lactam of formula (II) wherein the symbols are as defined, with a base; and precursors therefor and processes for the preparation of the precursors. The compounds of formula (I) are pharmaceutically active compounds which are selective inhibitors of Cyclooxygenase (II).

公开(公告)号：EP2007784A2

公开(公告)日：2008-12-31

申请号：EP07726952.0

申请日：2007-03-15

申请人： NOVARTIS AG

发明人： CERCUS, Jacques ,  FOULKES, Michael ,  HEINZ, Thomas ,  NIEDERER, Daniel ,  SCHMITZ, Beat

IPC分类号： C07H19/073

CPC分类号： C07H19/073

摘要： A novel method has been found to produce 2,2'-anhydro-1-(β-L- arabinofuranosyl)thymine as a novel useful intermediate compound. A novel method has been further found to produce thymidine from 2,2'-anhydro-1- (β-L-arabinofuranosyl)thymine. According to these methods, synthesis of various L- nucleic acid derivatives, synthesis of which has been difficult till now.