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    COMBINATION OF AN ACE INHIBITOR, A CALCIUM CHANNEL BLOCKER AND A DIURETIC
    3.
    发明公开
    COMBINATION OF AN ACE INHIBITOR, A CALCIUM CHANNEL BLOCKER AND A DIURETIC 审中-公开
    组合的ACE抑制剂，钙通道阻滞剂和利尿剂

    公开(公告)号：EP1507537A1

    公开(公告)日：2005-02-23

    申请号：EP03752758.7

    申请日：2003-05-16

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： GRIGORIEFF, Melissa ,  SHETTY, Suraj, Shivappa ,  WEBB, Randy, Lee

    IPC分类号： A61K31/55 ,  A61K31/4422 ,  A61K31/549

    CPC分类号： A61K31/455 ,  A61K31/4422 ,  A61K31/549 ,  A61K31/55 ,  A61K2300/00

    摘要： The present invention relates to a method of treatment of a condition or disease selected from the group consisting of hypertension, left ventricular dysfunction and hypertrophic cardiomyopathy, diabetic cardiac myopahty, supraventricular and ventricular arrhythmias, atrial fibrillation, atrial flutter, detrimental vascular remodeling, myocardial infarction and its sequelae, antheroscleorosis, angina (whether unstable or stable), renal insufficiency (diabetic and non-diabetic), heart failure, angina pectoris, diabetes, secondary aldosteronism, primary and secondary pulmonary hypertension, renal failure conditions, such as diabetic nephropathy, glomerulonephritis, scleroderma, glomecular sclerosis, proteinuria of primary renal disease,and also renal vascular hypertension, diabetic retinophathy, the management of other vascular disorders, such as migraine, peripheral vascular disease, Raynaud´s disease, luminal hyperplasia, endothelial dysfunction, cognitive dysfunction( such as Alzheimer's), glaucoma and stroke, comprising administering, to a mammal in need thereof, a therapeutically effective amount of a combination comprising (i) an ACE inhibitor, (ii) a calcium channel blocker (CCB), and (iii) a diuretic.

    COMBINATION OF A DPP IV INHIBITOR AND A CARDIOVASCULAR COMPOUND
    4.
    发明公开
    COMBINATION OF A DPP IV INHIBITOR AND A CARDIOVASCULAR COMPOUND 审中-公开
    组合的DPP-IV抑制剂和心血管CONNECTION作者

    公开(公告)号：EP1511484A1

    公开(公告)日：2005-03-09

    申请号：EP03755149.6

    申请日：2003-05-28

    申请人： Novartis AG ,  Novartis Pharma GmbH

    发明人： HOLMES, David, Grenville ,  SHETTY, Suraj, Shivappa ,  HUGHES, Thomas, Edward

    IPC分类号： A61K31/454 ,  A61K31/40 ,  A61K31/16 ,  A61P3/10 ,  A61K31/41

    CPC分类号： A61K31/454 ,  A61K31/16 ,  A61K31/40 ,  A61K31/41

    摘要： The present invention relates to a combination, such as a combined preparation or pharmaceutical composition, respectively, comprising of a DPP IV inhibitor or a pharmaceutically acceptable salt thereof and a cardiovascular compound (being different from a statin) or a pharmaceutically acceptable salt thereof. The present invention furthermore relates to the use of such a combination for the prevention, delay of progression or treatment of diseases and disorders selected from the group consisting of hypertension, congestive heart failure, left ventricular hypertrophy, peripheral arterial disease, diabetes, especially type 2 diabetes mellitus, diabetic retinophathy, macular degeneration, cataract, diabetic nephropathy, glomerulosclerosis, chronic renal failure, diabetic neuropathy, syndrome X, premenstrual syndrome, coronary heart disease, angina pectoris, thrombosis, atherosclerosis, myocardial infarction, transient ischemic attacks, stroke, vascular restenosis, hyperglycemia, hyperinsulinemia, hyperlipidemia, hypertryglyceridemia, insulin resistance, impaired glucose metabolism, conditions of impaired glucose tolerance, conditions of impaired fasting plasma glucose, obesity, erectile dysfunction, skin and connective tissue disorders, foot ulcerations and ulcerative colitis, endothelial dysfunction and impaired vascular compliance.