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1.发明公开2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS 有权FOR肿瘤性疾病，炎性疾病和疾患，免疫系统的适当的2.4 PYRIMIDINDIAMINE的治疗
公开(公告)号：EP1660458A1
公开(公告)日：2006-05-31
申请号：EP04764093.3
申请日：2004-08-13
申请人： Novartis AG , Novartis Pharma GmbH , IRM LLC
发明人： GARCIA-ECHEVERRIA, Carlos , KANAZAWA, Takanori , KAWAHARA, Eiji , MASUYA, Keiichi , MATSUURA, Naoko , MIYAKE, Takahiro , OHMORI, Osamu , UMEMURA, Ichiro , STEENSMA, Ruo , CHOPIUK, Greg , JIANG, Jiqing , WAN, Yongqin , DING, Qiang , ZHANG, Qiong , GRAY, Nathanael, Schiander , KARANEWSKY, Donald
IPC分类号： C07D239/48 , C07D405/12 , C07D403/12 , C07D401/12 , C07D401/14 , A61K31/506 , A61K35/00 , A61P37/00 , A61P29/00
CPC分类号： C07D239/48 , C04B35/632 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14
摘要： Novel pyrimidine derivatives of formula (I) Wherein R is selected from C16-10 aryl, C5-10heteroaryl, C3-12cycloalkyl and C3-10heterocycloalkyl; R0-R6 as described herein; and their use for the manufacture of a medicament for the treatment or prevention of a disease wich responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR.
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2.发明授权2, 4-PYRIMIDINEDIAMINES USEFUL IN THE TREATMENT OF NEOPLASTIC DISEASES, INFLAMMATORY AND IMMUNE SYSTEM DISORDERS 有权FOR肿瘤性疾病，炎性疾病和疾患，免疫系统的适当的2.4 PYRIMIDINDIAMINE的治疗
公开(公告)号：EP1660458B1
公开(公告)日：2012-01-25
申请号：EP04764093.3
申请日：2004-08-13
申请人： Novartis AG , IRM LLC
发明人： GARCIA-ECHEVERRIA, Carlos , KANAZAWA, Takanori , KAWAHARA, Eiji , MASUYA, Keiichi , MATSUURA, Naoko , MIYAKE, Takahiro , OHMORI, Osamu , UMEMURA, Ichiro , STEENSMA, Ruo , CHOPIUK, Greg , JIANG, Jiqing , WAN, Yongqin , DING, Qiang , ZHANG, Qiong , GRAY, Nathanael, Schiander , KARANEWSKY, Donald
IPC分类号： C07D239/48 , C07D405/12 , C07D403/12 , C07D401/12 , C07D401/14 , A61K31/506 , A61K35/00 , A61P37/00 , A61P29/00
CPC分类号： C07D239/48 , C04B35/632 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14
摘要： Novel pyrimidine derivatives of formula (I) Wherein R is selected from C16-10 aryl, C5-10heteroaryl, C3-12cycloalkyl and C3-10heterocycloalkyl; R0-R6 as described herein; and their use for the manufacture of a medicament for the treatment or prevention of a disease wich responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR.
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