公开(公告)号：EP1660458A1

公开(公告)日：2006-05-31

申请号：EP04764093.3

申请日：2004-08-13

申请人： Novartis AG ,  Novartis Pharma GmbH ,  IRM LLC

发明人： GARCIA-ECHEVERRIA, Carlos ,  KANAZAWA, Takanori ,  KAWAHARA, Eiji ,  MASUYA, Keiichi ,  MATSUURA, Naoko ,  MIYAKE, Takahiro ,  OHMORI, Osamu ,  UMEMURA, Ichiro ,  STEENSMA, Ruo ,  CHOPIUK, Greg ,  JIANG, Jiqing ,  WAN, Yongqin ,  DING, Qiang ,  ZHANG, Qiong ,  GRAY, Nathanael, Schiander ,  KARANEWSKY, Donald

IPC分类号： C07D239/48 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K35/00 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D239/48 ,  C04B35/632 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

摘要： Novel pyrimidine derivatives of formula (I) Wherein R is selected from C16-10 aryl, C5-10heteroaryl, C3-12cycloalkyl and C3-10heterocycloalkyl; R0-R6 as described herein; and their use for the manufacture of a medicament for the treatment or prevention of a disease wich responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR.

公开(公告)号：EP1660458B1

公开(公告)日：2012-01-25

申请号：EP04764093.3

申请日：2004-08-13

申请人： Novartis AG ,  IRM LLC

发明人： GARCIA-ECHEVERRIA, Carlos ,  KANAZAWA, Takanori ,  KAWAHARA, Eiji ,  MASUYA, Keiichi ,  MATSUURA, Naoko ,  MIYAKE, Takahiro ,  OHMORI, Osamu ,  UMEMURA, Ichiro ,  STEENSMA, Ruo ,  CHOPIUK, Greg ,  JIANG, Jiqing ,  WAN, Yongqin ,  DING, Qiang ,  ZHANG, Qiong ,  GRAY, Nathanael, Schiander ,  KARANEWSKY, Donald

IPC分类号： C07D239/48 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K35/00 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D239/48 ,  C04B35/632 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14

摘要： Novel pyrimidine derivatives of formula (I) Wherein R is selected from C16-10 aryl, C5-10heteroaryl, C3-12cycloalkyl and C3-10heterocycloalkyl; R0-R6 as described herein; and their use for the manufacture of a medicament for the treatment or prevention of a disease wich responds to inhibition of FAK and/or ALK and/or ZAP-70 and/or IGF-IR.

公开(公告)号：EP1487805B1

公开(公告)日：2012-07-04

申请号：EP03744366.0

申请日：2003-03-14

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： BAENTELI, Rolf ,  ZENKE, Gerhard ,  COOKE, Nigel, Graham ,  DUTHALER, Rudolf ,  THOMA, Gebhard ,  VON MATT, Anette ,  HONDA, Toshiyuki ,  MATSUURA, Naoko ,  NONOMURA, Kazuhiko ,  OHMORI, Osamu ,  UMEMURA, Ichiro ,  HINTERDING, Klaus ,  PAPAGEORGIOU, Christos

IPC分类号： C07D239/48 ,  A61K31/505 ,  A61P35/04

CPC分类号： C07D239/48 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/12

摘要： There are provided compounds of formula (I), wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.

公开(公告)号：EP1968941A1

公开(公告)日：2008-09-17

申请号：EP06829878.5

申请日：2006-12-27

申请人： Novartis AG

发明人： SAKAKI, Junichi ,  KISHIDA, Masashi ,  MATSUURA, Naoko ,  UMEMURA, Ichiro ,  KAWAHARA, Eiji ,  YAMADA, Ken ,  KONISHI, Kazuhide ,  IWAKI, Yuki ,  IMASE, Hidetomo ,  MIYAKE, Takahiro

IPC分类号： C07D213/38 ,  C07D213/40 ,  C07D401/12 ,  A61K31/44 ,  A61K31/4439 ,  A61P3/00 ,  A61P9/00

CPC分类号： C07D401/12 ,  C07D213/74 ,  C07D401/14 ,  C07D405/14 ,  C07D409/14

摘要： The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein the variables are as defined, useful as inhibitors of chlosteryl ester transfer protein.

摘要翻译： 本发明涉及式（I）化合物或其药学上可接受的盐，其中变量如所定义，可用作氯代酯转移蛋白的抑制剂。

公开(公告)号：EP2024356A1

公开(公告)日：2009-02-18

申请号：EP07724982.9

申请日：2007-05-08

申请人： NOVARTIS AG

发明人： KISHIDA, Masashi ,  MATSUURA, Naoko ,  IMASE, Hidetomo ,  IWAKI, Yuki ,  UMEMURA, Ichiro ,  OHMORI, Osamu ,  KAWAHARA, Eiji

IPC分类号： C07D401/12 ,  C07D401/14 ,  C07D471/04 ,  A61K31/4427 ,  A61P9/00

CPC分类号： C07D471/04 ,  C07D401/12 ,  C07D401/14

摘要： The present invention relates to novel compounds of formula (I): or a pharmaceutical composition thereof, with all the variables being defined in the text. The present invention further relates to the use of the compounds herein for treatment of or delay progression to overt to diseases in which CETP is involved.

公开(公告)号：EP1606265A1

公开(公告)日：2005-12-21

申请号：EP04719989.8

申请日：2004-03-12

申请人： Novartis AG ,  Novartis Pharma GmbH

发明人： .GARCIA-ECHEVERRIA, Carlos ,  KANAZAWA, Takanori ,  KAWAHARA, Eiji ,  MASUYA, Keiichi ,  MATSUURA, Naoko ,  MIYAKE, Takahiro ,  OHMORI, Osamu ,  UMEMURA, Ichiro

IPC分类号： C07D239/48 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K35/00 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D401/12 ,  C07D239/48 ,  C07D401/14

摘要： Novel pyrimidine derivatives of formula (I), to processes for their production, their use as pharmaceuticals in the treatment of neoplastic diseases, inflammatory and immune system disorders and to pharmaceutical compositions comprising them.

公开(公告)号：EP1606265B1

公开(公告)日：2011-02-02

申请号：EP04719989.8

申请日：2004-03-12

申请人： Novartis AG

发明人： .GARCIA-ECHEVERRIA, Carlos ,  KANAZAWA, Takanori ,  KAWAHARA, Eiji ,  MASUYA, Keiichi ,  MATSUURA, Naoko ,  MIYAKE, Takahiro ,  OHMORI, Osamu ,  UMEMURA, Ichiro

IPC分类号： C07D239/48 ,  C07D405/12 ,  C07D403/12 ,  C07D401/12 ,  C07D401/14 ,  A61K31/506 ,  A61K35/00 ,  A61P37/00 ,  A61P29/00

CPC分类号： C07D401/12 ,  C07D239/48 ,  C07D401/14

摘要： Novel pyrimidine derivatives of formula (I), to processes for their production, their use as pharmaceuticals in the treatment of neoplastic diseases, inflammatory and immune system disorders and to pharmaceutical compositions comprising them.

公开(公告)号：EP1487805A1

公开(公告)日：2004-12-22

申请号：EP03744366.0

申请日：2003-03-14

申请人： Novartis AG

发明人： BAENTELI, Rolf ,  ZENKE, Gerhard ,  COOKE, Nigel, Graham ,  DUTHALER, Rudolf ,  THOMA, Gebhard ,  VON MATT, Anette ,  HONDA, Toshiyuki ,  MATSUURA, Naoko ,  NONOMURA, Kazuhiko ,  OHMORI, Osamu ,  UMEMURA, Ichiro ,  HINTERDING, Klaus ,  PAPAGEORGIOU, Christos

IPC分类号： C07D239/48 ,  A61K31/505 ,  A61P35/04

CPC分类号： C07D239/48 ,  A61K31/505 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D417/12

摘要： There are provided compounds of formula (I), wherein X, R1, R2, R3, R4, R5, R6, R7, R8 and R9 are as indicated in claim 1, useful in disorders where ZAP-70 and/or Syk inhibition plays a role or caused by a malfunction of signal cascades connected with FAK.

摘要翻译： 提供式（I）化合物，其中X，R 1，R 2，R 3，R 4，R 5，R 6，R 7，R 8和R 9如权利要求1中所示，可用于ZAP-70和/ 一个角色或由FAK连接的信号级联发生故障引起。