专利检索 ap:("Novartis AG" OR "Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.") AND inv:"CYR, Devon" 第 1 页

1.

发明公开
GENES FOR THE BIOSYNTHESIS OF EPOTHILONES 审中-公开
标题翻译：基因生物合成埃博霉素

公开(公告)号：EP1088078A2

公开(公告)日：2001-04-04

申请号：EP99929243.6

申请日：1999-06-16

申请人： Novartis AG , Novartis-Erfindungen Verwaltungsgesellschaft m.b.H.

发明人： SCHUPP, Thomas , LIGON, James, Madison , MOLNAR, Istvan , ZIRKLE, Ross , GÖRLACH, Jörn , CYR, Devon

IPC分类号： C12N15/52 , C07K14/535 , C07D493/00

CPC分类号： C12P17/181 , C07K14/195

摘要： Nucleic acid molecules are isolated from Sorangium cellulosum that encode polypeptides necessary for the biosynthesis of epothilone. Disclosed are methods for the production of epothilone in recombinant hosts transformed with the genes of the invention. In this manner, epothilone can be produced in quantities large enough to enable their purification and use in pharmaceutical formulations such as those for the treatment of cancer.