公开(公告)号：EP2292772A1

公开(公告)日：2011-03-09

申请号：EP10180448.2

申请日：2002-07-05

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Zur Megede, Jan ,  Barnett, Susan W. ,  Lian, Ying

IPC分类号： C12N15/74 ,  C07H21/04 ,  A61K39/21

CPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/16023 ,  C12N2740/16034 ,  C12N2740/16043 ,  C12N2740/16052 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  C12N2800/108 ,  C12N2830/42 ,  C12N2840/203

摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Use of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.

摘要翻译： 本发明涉及多核苷酸编码免疫原性HIV多肽。 因此使用的多核苷酸的到应用程序中包括免疫，产生的包装细胞系，和生产HIV多肽的描述。 多核苷酸编码的抗原多肽HIV被描述，因为是合成的多核苷酸的用途和多肽产物从那里，包括免疫原性组合物的配方和灰及其用途。

公开(公告)号：EP2281832A2

公开(公告)日：2011-02-09

申请号：EP10173861.5

申请日：2001-07-05

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Zur Megede, Jan ,  Barnett, Susan W.

IPC分类号： C07K14/16 ,  A61K39/21 ,  C12N5/10

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/53 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates to polynucleotides encoding immunogenic HIV type C polypeptides. Uses of the polynucleotides in applications including DNA immumization, generation of packaging cell lines, and production of HIV Tyre C proteins are also described.

摘要翻译： 本发明涉及编码免疫原性HIV C型多肽的多核苷酸。 还描述了多核苷酸在包括DNA纯化，包装细胞系的产生和HIV胎牛C蛋白的产生的应用中的用途。

公开(公告)号：EP2266602A2

公开(公告)日：2010-12-29

申请号：EP10178110.2

申请日：2005-11-01

申请人： Novartis Vaccines and Diagnostics, Inc. ,  The Government of the U.S.A. as represented by The Secretary of the dept. of Health & Human Services

发明人： Barnett, Susan W. ,  Gomez-Roman, Victor Raul ,  Robert-Guroff, Marjorie ,  Srivastava, Indresh K.

IPC分类号： A61K39/21 ,  C07K14/16

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2760/16134

摘要： The present invention relates to methods, polypeptides, and polynucleotides encoding immunogenic identical or analogous HIV polypeptides derived from the same or different strains within an HIV subtype and/or different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are also described. The combination approaches described herein induce broad and potent immune responses against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.

摘要翻译： 本发明涉及编码来自HIV亚型和/或不同亚型中的相同或不同菌株的免疫原性相同或类似的HIV多肽的方法，多肽和多核苷酸。 还描述了用于产生免疫应答的组合方法中多核苷酸和多肽的用途。 本文描述的组合方法诱导针对来自给定亚型中的多种菌株和针对不同亚型的多种HIV株的广泛和有效的免疫应答。 还公开了用于产生免疫应答的组合物的制剂和用于这种组合物的方法。

公开(公告)号：EP2412242A2

公开(公告)日：2012-02-01

申请号：EP11161076.2

申请日：2002-07-05

申请人： Novartis Vaccines and Diagnostics, Inc. ,  University of Stellenbosch

发明人： Zur Megede, Jan ,  Barnett, Susan W. ,  Lian, Ying ,  Engelbrecht, Susan ,  Van Rensburg, Estrelita Janse ,  Scriba, Thomas Jens

IPC分类号： A01N63/00 ,  A61K48/00 ,  C12N5/00 ,  C12N5/02 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C07H21/04 ,  C07K14/16 ,  C12N15/867

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  C12N15/86 ,  C12N2720/00034 ,  C12N2740/16043 ,  C12N2740/16052 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2799/027 ,  C12N2800/108 ,  C12N2830/42 ,  C12N2840/203

摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.

摘要翻译： 本发明涉及编码免疫原性HIV多肽的多核苷酸。 还描述了多核苷酸在包括免疫接种，包装细胞系产生和HIV多肽产生在内的应用中的用途。 描述了编码抗原性HIV多肽的多核苷酸，以及这些多核苷酸及其多肽产物的用途，包括免疫原性组合物的制剂及其用途。

公开(公告)号：EP2280074A3

公开(公告)日：2011-06-22

申请号：EP09178990.9

申请日：2002-07-05

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Zur Megede, Jan ,  Barnett, Susan W. ,  Lian, Ying

IPC分类号： C12N15/74 ,  C07H21/04 ,  A61K39/21

CPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/16023 ,  C12N2740/16034 ,  C12N2740/16043 ,  C12N2740/16052 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  C12N2800/108 ,  C12N2830/42 ,  C12N2840/203

摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Use of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.

公开(公告)号：EP2412242A3

公开(公告)日：2012-06-13

申请号：EP11161076.2

申请日：2002-07-05

申请人： Novartis Vaccines and Diagnostics, Inc. ,  University of Stellenbosch

发明人： Zur Megede, Jan ,  Barnett, Susan W. ,  Lian, Ying ,  Engelbrecht, Susan ,  Van Rensburg, Estrelita Janse ,  Scriba, Thomas Jens

IPC分类号： A01N63/00 ,  A61K48/00 ,  C12N5/00 ,  C12N5/02 ,  C12N15/00 ,  C12N15/09 ,  C12N15/63 ,  C12N15/70 ,  C12N15/74 ,  C07H21/04 ,  C07K14/16 ,  C12N15/867 ,  C07K14/005 ,  C12N15/86

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/53 ,  C12N15/86 ,  C12N2720/00034 ,  C12N2740/16043 ,  C12N2740/16052 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2799/027 ,  C12N2800/108 ,  C12N2830/42 ,  C12N2840/203

摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Uses of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.

公开(公告)号：EP2281832A3

公开(公告)日：2011-12-14

申请号：EP10173861.5

申请日：2001-07-05

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Zur Megede, Jan ,  Barnett, Susan W.

IPC分类号： C07K14/16 ,  A61K39/21 ,  C12N5/10

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/53 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16322

摘要： The present invention relates to polynucleotides encoding immunogenic HIV type C polypeptides. Uses of the polynucleotides in applications including DNA immumization, generation of packaging cell lines, and production of HIV Tyre C proteins are also described.

摘要翻译： 本发明涉及编码免疫原性HIV C型多肽的多核苷酸。 还描述了多核苷酸在包括DNA免疫，包装细胞系的产生和HIV轮胎C蛋白质产生的应用中的用途。

公开(公告)号：EP2266602A3

公开(公告)日：2011-08-10

申请号：EP10178110.2

申请日：2005-11-01

申请人： Novartis Vaccines and Diagnostics, Inc. ,  The Government of the U.S.A. as represented by The Secretary of the dept. of Health & Human Services

发明人： Barnett, Susan W. ,  Gomez-Roman, Victor Raul ,  Robert-Guroff, Marjorie ,  Srivastava, Indresh K.

IPC分类号： A61K39/21 ,  C07K14/16

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5256 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  C12N2710/10343 ,  C12N2740/16122 ,  C12N2760/16134

摘要： The present invention relates to methods, polypeptides, and polynucleotides encoding immunogenic identical or analogous HIV polypeptides derived from the same or different strains within an HIV subtype and/or different subtypes. Uses of the polynucleotides and polypeptides in combination approaches for generating immune responses are also described. The combination approaches described herein induce broad and potent immune responses against diverse HIV strains from multiple strains within a given subtype and against diverse subtypes. Formulations of compositions for generating immune responses and methods of use for such compositions are also disclosed.

公开(公告)号：EP2280074A2

公开(公告)日：2011-02-02

申请号：EP09178990.9

申请日：2002-07-05

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： Zur Megede, Jan ,  Barnett, Susan W. ,  Lian, Ying

IPC分类号： C12N15/74 ,  C07H21/04 ,  A61K39/21

CPC分类号： A61K39/21 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/545 ,  A61K2039/55566 ,  A61K2039/57 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/16023 ,  C12N2740/16034 ,  C12N2740/16043 ,  C12N2740/16052 ,  C12N2740/16122 ,  C12N2740/16222 ,  C12N2740/16234 ,  C12N2740/16322 ,  C12N2800/108 ,  C12N2830/42 ,  C12N2840/203

摘要： The present invention relates to polynucleotides encoding immunogenic HIV polypeptides. Use of the polynucleotides in applications including immunization, generation of packaging cell lines, and production of HIV polypeptides are also described. Polynucleotides encoding antigenic HIV polypeptides are described, as are uses of these polynucleotides and polypeptide products therefrom, including formulations of immunogenic compositions and uses thereof.

摘要翻译： 本发明涉及编码免疫原性HIV多肽的多核苷酸。 还描述了多核苷酸在包括免疫接种，包装细胞系产生和HIV多肽产生的应用中的用途。 描述了编码抗原性HIV多肽的多核苷酸，以及这些多核苷酸及其多肽产物的用途，包括免疫原性组合物的制剂及其用途。