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1.发明授权
公开(公告)号：EP1985701B1
公开(公告)日：2012-05-30
申请号：EP08010460.7
申请日：2001-01-09
IPC分类号： C12N15/11 , C12N15/12 , C12N15/62 , C12N15/86 , C12N5/10 , C07K14/47 , C07K16/18 , A61K31/713 , C12Q1/68 , G01N33/577 , G06F17/30
CPC分类号： C07K14/47 , C07K16/18 , C07K2319/00
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公开(公告)号：EP1953243A2
公开(公告)日：2008-08-06
申请号：EP08006693.9
申请日：2008-03-31
IPC分类号： C12Q1/68 , C12N15/11 , A61K31/00 , G01N33/574 , G01N33/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： The present invention is based on the discovery of polynucleotides that represent genes that are differentially expressed in colon cancer, e.g., adenomatous polyp, colorectal carcinoma, high metastatic potential colon tumor and metastatic colon cancer. The invention features methods of identifying cells affected by such colon diseases by detection of a gene product encoded by such differentially expressed genes, as well as method of modulating expression of such gene products to effect therapy (e.g., to decrease growth and/or affect abnormal characteristics of cancerous or displastic colon cells).
摘要翻译： 本发明基于代表在结肠癌中差异表达的基因的多核苷酸的发现，所述结肠癌例如腺瘤性息肉，结肠直肠癌，高转移潜能结肠肿瘤和转移性结肠癌。 本发明的特征在于通过检测由这种差异表达的基因编码的基因产物来鉴定受这种结肠疾病影响的细胞的方法，以及调节这种基因产物的表达以实现疗法（例如降低生长和/或影响异常 癌性或有代表性的结肠细胞的特征）。
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公开(公告)号：EP1985701A3
公开(公告)日：2009-01-07
申请号：EP08010460.7
申请日：2001-01-09
IPC分类号： C12N15/11 , C12N15/12 , C12N15/62 , C12N15/86 , C12N5/10 , C07K14/47 , C07K16/18 , A61K31/713 , C12Q1/68 , G01N33/577 , G06F17/30
CPC分类号： C07K14/47 , C07K16/18 , C07K2319/00
摘要： A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.
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4.发明公开
公开(公告)号：EP1985701A2
公开(公告)日：2008-10-29
申请号：EP08010460.7
申请日：2001-01-09
IPC分类号： C12N15/11 , C12N15/12 , C12N15/62 , C12N15/86 , C12N5/10 , C07K14/47 , C07K16/18 , A61K31/713 , C12Q1/68 , G01N33/577 , G06F17/30
CPC分类号： C07K14/47 , C07K16/18 , C07K2319/00
摘要： A polynucleotide sequence as shown in SEQ ID NO:1 is associated with metastatic potential of cancer cells, especially breast cancer cells. Methods are provided for determining the risk of metastasis of a tumor, by determining whether a tissue sample from a tumor expresses a polypeptide or mRNA encoded by a polynucleotide as shown in SEQ ID NO:1. Also provided are therapeutic methods and compositions.
摘要翻译： 如SEQ ID NO：1所示的多核苷酸序列与癌细胞，特别是乳腺癌细胞的转移潜能相关。 通过确定来自肿瘤的组织样品是否表达由多核苷酸编码的多肽，如SEQ ID NO：1所示，提供了用于确定肿瘤转移风险的方法。 还提供治疗方法和组合物。
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公开(公告)号：EP1953243B1
公开(公告)日：2012-12-26
申请号：EP08006693.9
申请日：2001-06-15
IPC分类号： C12Q1/68 , C12N15/11 , A61K31/00 , G01N33/574 , G01N33/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
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公开(公告)号：EP1953243A8
公开(公告)日：2008-11-19
申请号：EP08006693.9
申请日：2001-06-15
IPC分类号： C12Q1/68 , C12N15/11 , A61K31/00 , G01N33/574 , G01N33/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： The present invention is based on the discovery of polynucleotides that represent genes that are differentially expressed in colon cancer, e.g., adenomatous polyp, colorectal carcinoma, high metastatic potential colon tumor and metastatic colon cancer. The invention features methods of identifying cells affected by such colon diseases by detection of a gene product encoded by such differentially expressed genes, as well as method of modulating expression of such gene products to effect therapy (e.g., to decrease growth and/or affect abnormal characteristics of cancerous or displastic colon cells).
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公开(公告)号：EP1953243A3
公开(公告)日：2008-11-05
申请号：EP08006693.9
申请日：2008-03-31
IPC分类号： C12Q1/68 , C12N15/11 , A61K31/00 , G01N33/574 , G01N33/68
CPC分类号： C07K14/47 , C12Q1/6886 , C12Q2600/136
摘要： The present invention is based on the discovery of polynucleotides that represent genes that are differentially expressed in colon cancer, e.g., adenomatous polyp, colorectal carcinoma, high metastatic potential colon tumor and metastatic colon cancer. The invention features methods of identifying cells affected by such colon diseases by detection of a gene product encoded by such differentially expressed genes, as well as method of modulating expression of such gene products to effect therapy (e.g., to decrease growth and/or affect abnormal characteristics of cancerous or displastic colon cells).
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