公开(公告)号：EP1618087B1

公开(公告)日：2012-06-13

申请号：EP04700887.5

申请日：2004-01-08

申请人： Novartis Vaccines and Diagnostics, Inc. ,  University of Washington

发明人： ANDERSON, Niels H. ,  BOWMAN, Jason ,  ERWIN, Alice ,  HARWOOD, Eric ,  KLINE, Toni ,  MDLULI, Khisimuzi ,  NG, Simon ,  PFISTER, Keith B. ,  SHAWAR, Ribhi ,  WAGMAN, Allan ,  YABANNAVAR, Asha

IPC分类号： C07C233/00 ,  A61K31/16 ,  A61K31/165 ,  A61P31/00 ,  A61P31/04

CPC分类号： C07D453/00 ,  C07C233/83 ,  C07C239/16 ,  C07C251/40 ,  C07C255/24 ,  C07C255/25 ,  C07C255/44 ,  C07C255/57 ,  C07C259/06 ,  C07C275/14 ,  C07C275/16 ,  C07C275/26 ,  C07C279/14 ,  C07C311/06 ,  C07C311/08 ,  C07C311/19 ,  C07C311/21 ,  C07C317/32 ,  C07C323/25 ,  C07C323/41 ,  C07C323/60 ,  C07C323/62 ,  C07C335/08 ,  C07C337/08 ,  C07C381/00 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/14 ,  C07C2601/18 ,  C07C2602/42 ,  C07C2603/74 ,  C07D207/08 ,  C07D207/09 ,  C07D207/14 ,  C07D207/16 ,  C07D207/27 ,  C07D207/327 ,  C07D211/26 ,  C07D211/42 ,  C07D211/56 ,  C07D211/58 ,  C07D211/62 ,  C07D213/38 ,  C07D213/40 ,  C07D213/54 ,  C07D213/56 ,  C07D213/61 ,  C07D213/74 ,  C07D213/80 ,  C07D213/81 ,  C07D213/82 ,  C07D215/48 ,  C07D217/26 ,  C07D231/12 ,  C07D233/56 ,  C07D233/64 ,  C07D235/14 ,  C07D239/26 ,  C07D239/42 ,  C07D241/04 ,  C07D241/12 ,  C07D241/18 ,  C07D263/34 ,  C07D285/01 ,  C07D295/13 ,  C07D295/135 ,  C07D295/155 ,  C07D295/192 ,  C07D295/215 ,  C07D307/68 ,  C07D311/24 ,  C07D317/60 ,  C07D317/68 ,  C07D333/20 ,  C07D333/24 ,  C07D333/32 ,  C07D333/36 ,  C07D333/58

摘要： Antibacterial compounds of formula (I) are provided: As well as stereoisomers, pharmaceutically acceptable salts, esters, and prodrugs thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of the compounds.

公开(公告)号：EP1537099B1

公开(公告)日：2010-08-11

申请号：EP03749133.9

申请日：2003-08-21

申请人： Novartis Vaccines and Diagnostics, Inc.

发明人： DESAI, Manoj ,  NI, Zhi-Jie ,  NG, Simon ,  PFISTER, Keith, B. ,  RAMURTHY, Savithri ,  SUBRAMANIAN, Sharadha ,  WAGMAN, Allan, S.

IPC分类号： C07D401/12 ,  C07D521/00 ,  C07D405/14 ,  C07D401/14 ,  C07D453/02 ,  C07D413/14 ,  C07D487/08 ,  A61K31/4439 ,  A61P3/10

CPC分类号： C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D401/14 ,  C07D405/14 ,  C07D413/14 ,  C07D453/02 ,  C07D487/08

摘要： New pyrrole based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.