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公开(公告)号：EP3594222A1
公开(公告)日：2020-01-15
申请号：EP19186952.8
申请日：2004-12-01
发明人： HANSEN, Thomas Budde , HALKJÆR, Erik , PREUSS, Turid , TOMODA, Lene Vædele Madsen , JOHANSEN, Nina , CHRISTENSEN, Jesper
IPC分类号： C07K1/34 , C07K14/745 , C12N9/64 , C12N7/06
摘要： The present invention relates to a novel method for improving the viral safety of liquid Factor VII compositions, in particular those comprising active Factor VII polypeptides (a Factor VIIa polypeptide).
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2.发明授权REDUCTION OF THE CONTENT OF PROTEIN CONTAMINANTS IN COMPOSITIONS COMPRISING A VITAMIN K-DEPENDENT PROTEIN OF INTEREST 有权在蛋白质污染物含量的降低组合物INTEREST维生素K依赖性蛋白质INCLUDE
公开(公告)号：EP1831242B1
公开(公告)日：2012-09-26
申请号：EP05850495.2
申请日：2005-12-23
发明人： KRARUP, Janus , HANSEN, Thomas Budde , ARENTSEN, Anne, Charlotte , RASMUSSEN, Daniel, E. , BOGSNES, Are , STABY, Arne , AHMADIAN, Haleh , BANG, Susanne
IPC分类号： C07K1/16 , C07K14/745
CPC分类号： C07K14/745 , C07K1/16 , C07K1/22
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3.发明公开REDUCTION OF THE CONTENT OF PROTEIN CONTAMINANTS IN COMPOSITIONS COMPRISING A VITAMIN K-DEPENDENT PROTEIN OF INTEREST 有权在蛋白质污染物含量的降低组合物INTEREST维生素K依赖性蛋白质INCLUDE
公开(公告)号：EP1831242A1
公开(公告)日：2007-09-12
申请号：EP05850495.2
申请日：2005-12-23
发明人： BANG, Susanne , AHMADIAN, Haleh , STABY, Arne , BOGSNES, Are , RASMUSSEN, Daniel, E. , ARENTSEN, Anne, Charlotte , HANSEN, Thomas Budde , KRARUP, Janus
IPC分类号： C07K1/16 , C07K14/745
CPC分类号： C07K14/745 , C07K1/16 , C07K1/22
摘要： The present invention relates to Vitamin K-dependent protein compositions having a very low, or negligible, content of protein contaminants. The present invention also relates to method applicable in the preparation of such Vitamin K-dependent protein compositions. Such methods may either be used alone or in sequential combination with the purpose of reducing the relative content of protein contaminants. The present invention is particularly relevant in the preparation of compositions of coagulation factors selected from Factor X polypeptides (FX/FXa), Factor IX polypeptides (FIX/FIXa), Factor VII polypeptides (FVII/FVIIa), and the anticoagulant Protein C, in particular Factor VII polypeptides.
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公开(公告)号：EP3079722A1
公开(公告)日：2016-10-19
申请号：EP14818938.4
申请日：2014-12-15
CPC分类号： A61K47/48061 , A61K47/542 , A61K47/545 , A61K47/557 , C07K1/1077
摘要： The invention relates to methods for obtaining a protein conjugate wherein a cysteine residue of the protein serves as attachment point for the chemical moiety conjugated to the protein.
摘要翻译： 本发明涉及用于获得蛋白质缀合物的方法，其中蛋白质的半胱氨酸残基充当与蛋白质缀合的化学部分的连接点。
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