公开(公告)号：EP3179857A4

公开(公告)日：2018-04-11

申请号：EP15831770

申请日：2015-07-20

申请人： ALHAMADSHEH MAMOUN M ,  PARK MIKI S ,  CHAN WILLIAM K ,  LI XIAOLING ,  PENCHALA SRAVAN C ,  MILLER MARK R

发明人： ALHAMADSHEH MAMOUN M ,  PARK MIKI S ,  CHAN WILLIAM K ,  LI XIAOLING ,  PENCHALA SRAVAN C ,  MILLER MARK R

IPC分类号： A01N43/38 ,  A61K38/00 ,  C07D231/00

CPC分类号： A61K47/64 ,  A61K31/00 ,  A61K31/4745 ,  A61K38/00 ,  A61K47/48061 ,  A61K47/545 ,  A61K49/0052 ,  C07D231/12

摘要： A delivery system for active agents, and methods of making and using the systems, are provided. The delivery systems have (i) a ligand that is selective for an endogeneous plasma protein in the serum of a subject; and, (ii) a linker configured for operatively attaching the ligand covalently to an active agent to increase the half-life of the active agent in the serum.

公开(公告)号：EP3206710A4

公开(公告)日：2017-12-20

申请号：EP15845481

申请日：2015-09-23

申请人： INDIANA UNIV RESEARCH & TECHNOLOGY CORPORATION

发明人： LIU FA ,  DIMARCHI RICHARD D ,  MAYER JOHN P ,  SMILEY DAVID L

IPC分类号： A61K38/28

CPC分类号： A61K47/48246 ,  A61K9/0019 ,  A61K9/0024 ,  A61K38/00 ,  A61K38/22 ,  A61K38/28 ,  A61K47/02 ,  A61K47/48061 ,  A61K47/64 ,  C07K2/00 ,  C07K14/575 ,  C07K14/605 ,  C07K14/62

摘要： Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and the corresponding incretin receptor, and stimulates weight loss in an individual administered the compound.

公开(公告)号：EP3129064A4

公开(公告)日：2017-10-25

申请号：EP15758717

申请日：2015-03-03

申请人： MADRIGAL PHARMACEUTICALS INC

发明人： CHIMMANAMADA DINESH U ,  YING WEIWEN

IPC分类号： A61K47/50

CPC分类号： A61K47/48061 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/519 ,  A61K31/58 ,  A61K31/706 ,  A61K47/545 ,  A61K47/55

摘要： The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.

公开(公告)号：EP3223860A1

公开(公告)日：2017-10-04

申请号：EP15863680.3

申请日：2015-11-24

申请人： Endocyte, Inc. ,  Purdue Research Foundation

发明人： LU, Yingjuan J. ,  WHEELER, II Leroy W. ,  LEAMON, Christopher P. ,  LOW, Philip Stewart

IPC分类号： A61K47/68

CPC分类号： A61K38/08 ,  A61K47/48061 ,  A61K47/551 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  G01N33/57492 ,  G01N2333/705

摘要： Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker are described. Methods for treating cancers using one or more compounds comprising a folate receptor binding ligand attached to a drug via a linker to target tumor associated macrophages are described.

摘要翻译： 描述了使用一种或多种化合物治疗癌症的方法，所述化合物包含经由接头连接至药物的叶酸受体结合配体。 描述了使用一种或多种化合物治疗癌症的方法，所述化合物包含经由接头连接至药物的叶酸盐受体结合配体以靶向肿瘤相关巨噬细胞。

公开(公告)号：EP3035938A4

公开(公告)日：2017-04-19

申请号：EP14844064

申请日：2014-09-10

IPC分类号： A61K31/52 ,  A61K31/167 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/42 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/497 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/565 ,  A61K31/58 ,  A61K31/704 ,  A61K38/05

CPC分类号： A61K47/48061 ,  A61K31/167 ,  A61K31/4184 ,  A61K31/4188 ,  A61K31/42 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/4745 ,  A61K31/495 ,  A61K31/497 ,  A61K31/506 ,  A61K31/513 ,  A61K31/519 ,  A61K31/565 ,  A61K31/58 ,  A61K31/704 ,  A61K38/05 ,  A61K47/545

摘要： The present invention provides pharmacological compounds including an effector moiety conjugated to a binding moiety that directs the effector moiety to a biological target of interest. Likewise, the present invention provides compositions, kits, and methods (e.g., therapeutic, diagnostic, and imaging) including the compounds. The compounds can be described as a protein interacting binding moiety-drug conjugate (SDC-TRAP) compounds, which include a protein interacting binding moiety and an effector moiety. For example, in certain embodiments directed to treating cancer, the SDC-TRAP can include an Hsp90 inhibitor conjugated to a cytotoxic agent as the effector moiety.

摘要翻译： 本发明提供药物化合物，其包括与将效应子部分指向感兴趣的生物靶标的结合部分缀合的效应部分。 同样，本发明提供包括化合物的组合物，试剂盒和方法（例如治疗，诊断和成像）。 该化合物可被描述为蛋白质相互作用结合部分 - 药物偶联物（SDC-TRAP）化合物，其包括蛋白质相互作用结合部分和效应部分。 例如，在针对治疗癌症的某些实施方案中，SDC-TRAP可包括与细胞毒性剂缀合的Hsp90抑制剂作为效应部分。

公开(公告)号：EP2790667B1

公开(公告)日：2017-03-22

申请号：EP12801613.6

申请日：2012-12-14

申请人： DSM IP Assets B.V.

发明人： ZUPANCICH, John Andrew

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K9/70

CPC分类号： B29C41/003 ,  A61K9/0019 ,  A61K9/0024 ,  A61K9/7007 ,  A61K38/27 ,  A61K38/385 ,  A61K47/34 ,  A61K47/48061 ,  A61K47/545 ,  B29C41/12 ,  B29K2077/00 ,  B29K2105/0035 ,  B29K2105/007 ,  B29K2105/0085 ,  B29K2883/00 ,  B29L2007/008 ,  B29L2031/753

公开(公告)号：EP2920167A4

公开(公告)日：2016-07-20

申请号：EP13855289

申请日：2013-11-14

申请人： REDWOOD BIOSCIENCE INC

发明人： KUDIRKA ROMAS ALVYDAS ,  ALBERS AARON EDWARD ,  BARFIELD ROBYN M ,  RABUKA DAVID

IPC分类号： C07D403/00

CPC分类号： A61K47/545 ,  A61K47/48061 ,  A61K47/48246 ,  A61K47/48384 ,  A61K47/48715 ,  A61K47/64 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6889 ,  A61K49/0041 ,  A61K49/0058 ,  G01N33/582

摘要： The present disclosure provides conjugate structures (e.g., polypeptide conjugates) and hydrazinyl-indole compounds used to produce these conjugates. The disclosure also provides methods of production of such conjugates, as well as methods of using the same.

公开(公告)号：EP2822386A1

公开(公告)日：2015-01-14

申请号：EP13754418.5

申请日：2013-02-28

申请人： Purdue Research Foundation

发明人： LOW, Philip Stewart ,  VAITILINGAM, Balasubramanian ,  CHELVAM, Venkatesh

IPC分类号： A01N43/54

CPC分类号： A61K47/48061 ,  A61K31/475 ,  A61K38/06 ,  A61K47/545 ,  A61K47/551 ,  A61K49/0052 ,  A61K51/0459

摘要： The invention described herein pertains to targeted drug delivery conjugates comprising folate receptor α (FR-α) selective binding ligands and methods for diagnosing, monitoring, and eliminating pathological cells that express FR-α.

公开(公告)号：EP2667899A1

公开(公告)日：2013-12-04

申请号：EP12708721.1

申请日：2012-01-24

申请人： Novo Nordisk A/S

发明人： KODRA, János, Tibor ,  CONDE-FRIEBOES, Kilian, Waldemar ,  PAULSSON, Johan, Fredrik ,  RAUN, Kirsten

IPC分类号： A61K47/48 ,  A61P3/04

CPC分类号： C07K14/5759 ,  A61K38/22 ,  A61K38/2264 ,  A61K47/48038 ,  A61K47/48061 ,  A61K47/542 ,  A61K47/545

摘要： The invention relates to Leptin derivatives, compositions and therapeutic use there-of.

公开(公告)号：EP2289560A3

公开(公告)日：2011-10-19

申请号：EP10176012.2

申请日：2005-06-21

申请人： NOVO NORDISK A/S

发明人： Dörwald, Florencio Zaragoza ,  Schodt, Christine Bruun ,  Kruse, Thomas ,  Madsen, Kjeld

IPC分类号： A61K47/48 ,  A61P3/08 ,  A61P3/10

CPC分类号： A61K47/48061 ,  A61K31/41 ,  A61K38/27 ,  A61K47/54 ,  A61K47/545 ,  C07D257/04 ,  C07K1/006 ,  C07K1/113 ,  C07K14/61

摘要： Method for increasing half-life of compounds in plasma and novel derivatives of such compounds.