CRYSTAL METABOLITE RECOVERY
    4.
    发明公开
    CRYSTAL METABOLITE RECOVERY 有权
    回收晶体代谢物

    公开(公告)号:EP2552934A1

    公开(公告)日:2013-02-06

    申请号:EP11710201.2

    申请日:2011-03-25

    申请人: Novozymes A/S

    IPC分类号: C07K1/14 C07K1/30

    CPC分类号: C07K1/30 C07K1/306

    摘要: A method for producing a crystalline and/or amorphous metabolite suspension from a cell fermentation broth in a continuous centrifuge process comprising (a) adding at a separate inlet to the centrifuge the fermentation broth comprising the cells and the metabolite of interest, wherein the metabolite is partly or wholly on crystalline and/or amorphous form; (b) adding at another inlet to the centrifuge an aqueous liquid comprising a salt and/or a carbohydrate having a higher density than the cells and a lower density than the metabolite of interest in its precipitated form; (c) removing the cells at a separate outlet to the centrifuge; and (d) removing the suspension comprising the crystalline and/or amorphous metabolite of interest at another outlet to the centrifuge.