专利检索 ap:("Novuspharma S.p.A.") AND inv:"D'ALO', Simonetta" 第 1 页

1.

发明授权
BIS-PHOSPHONATE CONJUGATES WITH ALKYLATING MOIETIES HAVING ANTITUMOR ACTIVITY 失效
标题翻译：双膦酸盐类抗肿瘤用烷基化UNITS

公开(公告)号：EP0971939B1

公开(公告)日：2002-09-11

申请号：EP98917062.6

申请日：1998-03-24

申请人： Novuspharma S.p.A.

发明人： LIVI, Valeria , SPINELLI, Silvano , CONTI, Marco , D'ALO', Simonetta , MENTA, Ernesto

IPC分类号： C07F9/38 , A61K31/66 , C07F9/40

CPC分类号： C07F9/3869 , C07F9/4046

2.

发明公开
BIS-PHOSPHONATE CONJUGATES WITH ALKYLATING MOIETIES HAVING ANTITUMOR ACTIVITY 失效
标题翻译：双膦酸盐类抗肿瘤用烷基化UNITS

公开(公告)号：EP0971939A1

公开(公告)日：2000-01-19

申请号：EP98917062.6

申请日：1998-03-24

申请人： Novuspharma S.p.A.

发明人： LIVI, Valeria , SPINELLI, Silvano , CONTI, Marco , D'ALO', Simonetta , MENTA, Ernesto

IPC分类号： C07F9/38 , A61K31/66 , C07F9/40

CPC分类号： C07F9/3869 , C07F9/4046

摘要： The present invention relates to conjugates of 3-carboxy-4,4'-dihydroxyphosphorylbutenoic acids with alkylating agents. Such derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.