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公开(公告)号：EP1194438B1
公开(公告)日：2003-04-02
申请号：EP00943992.8
申请日：2000-07-05
申请人： Novuspharma S.p.A.
发明人： MENTA, Ernesto , DA RE, Giovanni
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： Nitrates of Bis-platinum complexes with polyamine ligands of formula (I) having antitumor activity and pharmaceutical compositions containing said compounds as active principles.
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公开(公告)号：EP1200439A1
公开(公告)日：2002-05-02
申请号：EP00949428.7
申请日：2000-07-31
申请人： Novuspharma S.p.A.
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04
摘要： Compounds of formula (I) wherein R, R1, X and Y have the meanings defined in the disclosure, have antitumor activity against solid tumors.
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3.发明公开2-(1H-INDOL-3-YL)-2-OXO-ACETIC ACID AMIDES WITH ANTITUMOR ACTIVITY 审中-公开2-（1H-吲哚-3-基）-2-氧代ESSIGSÄURENAMIDE具有抗肿瘤效果
公开(公告)号：EP1322646A1
公开(公告)日：2003-07-02
申请号：EP01955346.0
申请日：2001-07-12
申请人： Novuspharma S.p.A.
IPC分类号： C07D417/12 , A61K31/433 , C07D403/12 , C07D413/12 , A61P35/00
CPC分类号： C07D403/12 , C07D413/12 , C07D417/12
摘要： 2-(1H-Indol-3-yl)-2-oxo-acetamide derivatives of formula (I) having antitumor activity in particular against solid tumors, specifically colon and lung tumors.
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公开(公告)号：EP1200454A1
公开(公告)日：2002-05-02
申请号：EP00958309.7
申请日：2000-07-28
申请人： Novuspharma S.p.A.
CPC分类号： C07F15/0093
摘要： Compositions of formula (I), wherein X is halogen (chlorine, bromine, iodine); n, m = integer 2 to 8; p = 1, 2; A is selected from the group consisting of -B-, -B-(CH2)r-B-, -B-(CH2)r-B-(CH2)z-B-, with r and z ranging from 2-8; B is a group of formula -NR- wherein R is a group convertible into a hydrogen atom under physiological conditions, with the proviso that R is different from C1-C4 alkyl or acyl and from tert-butoxycarbonyl. Q-p is an anion selected from the group of chloride, bromide, iodide nitrate, sulfate, hydrogen sulfate and perchlorate.
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公开(公告)号：EP0750619B1
公开(公告)日：2001-05-30
申请号：EP95913595.5
申请日：1995-03-08
IPC分类号： C07D471/06 , C07D487/06 , A61K31/435 , A61K31/50 , A61K31/495
CPC分类号： C07D471/06 , C07D487/06
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6.发明公开
公开(公告)号：EP1244652A1
公开(公告)日：2002-10-02
申请号：EP00985225.2
申请日：2000-12-21
申请人： Novuspharma S.p.A.
IPC分类号： C07D405/12 , A61K31/404 , C07D409/12 , A61P35/00
CPC分类号： C07D405/12 , C07D409/12
摘要： 2-(1H-Indol-3-yl)-2-oxo-acetamides having antitumor activity, in particular against solid tumors, more precisely colon and lung tumors, of the following formula (I) wherein Y is an oxygen of sulfur atom and X, R1, R2, R3, R4 and R5 are as defined in claim 1.
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7.发明公开
公开(公告)号：EP0971939A1
公开(公告)日：2000-01-19
申请号：EP98917062.6
申请日：1998-03-24
申请人： Novuspharma S.p.A.
CPC分类号： C07F9/3869 , C07F9/4046
摘要： The present invention relates to conjugates of 3-carboxy-4,4'-dihydroxyphosphorylbutenoic acids with alkylating agents. Such derivatives are endowed with marked antitumor activity, especially against multiple myeloma. The present invention relates as well to a process for the preparation thereof and to pharmaceutical compositions containing them.
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公开(公告)号：EP1194438A1
公开(公告)日：2002-04-10
申请号：EP00943992.8
申请日：2000-07-05
申请人： Novuspharma S.p.A.
发明人： MENTA, Ernesto , DA RE, Giovanni
IPC分类号： C07F15/00
CPC分类号： C07F15/0093
摘要： Nitrates of Bis-platinum complexes with polyamine ligands of formula (I) having antitumor activity and pharmaceutical compositions containing said compounds as active principles.
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公开(公告)号：EP1200439B1
公开(公告)日：2003-06-25
申请号：EP00949428.7
申请日：2000-07-31
申请人： Novuspharma S.p.A.
IPC分类号： C07D487/04 , A61K31/4985 , A61P35/00
CPC分类号： C07D487/04
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10.发明授权
公开(公告)号：EP0971939B1
公开(公告)日：2002-09-11
申请号：EP98917062.6
申请日：1998-03-24
申请人： Novuspharma S.p.A.
CPC分类号： C07F9/3869 , C07F9/4046
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