公开(公告)号：EP3031812B1

公开(公告)日：2018-08-01

申请号：EP16150494.9

申请日：2012-02-29

申请人： NuCana plc

发明人： MCGUIGAN, Christopher ,  BALZARINI, Jan ,  SLUSARCYZK, Magdalena ,  GONCZY, Blanka ,  MURZIANI, Paola

IPC分类号： C07F9/6558 ,  A61K31/675 ,  A61P35/00 ,  A61K31/7072 ,  C07F9/655 ,  C07F9/6584 ,  C07H19/10

CPC分类号： A61K31/7072 ,  A61K45/06 ,  C07F9/65515 ,  C07F9/65586 ,  C07F9/65844 ,  C07H19/10

摘要： Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.

公开(公告)号：EP4023299A1

公开(公告)日：2022-07-06

申请号：EP21209926.1

申请日：2012-02-29

申请人： Nucana PLC

发明人： MCGUIGAN, Christopher ,  BALZARINI, Jan ,  SLUSARCYZK, Magdalena ,  GONCZY, Blanka ,  MURZIANI, Paola

IPC分类号： A61P35/00 ,  A61K45/06 ,  A61P35/02 ,  A61P43/00

摘要： Phosphoramidate derivatives of 5-fluoro-2'-deoxyuridine are disclosed for use in the treatment of cancer, especially in the treatment of cancer where the patient shows resistance, for example, in a patient with cells with a lowered level of nucleoside transporter proteins and/or with nucleoside kinase-deficient cells and/or with mycoplasma-infected cells and/or with cells with a raised level of thymidylate synthase.