公开(公告)号：EP0417445A1

公开(公告)日：1991-03-20

申请号：EP90114450.1

申请日：1990-07-27

申请人： OCCIDENTAL CHEMICAL CORPORATION

发明人： Fertel, Lawrence B. ,  O'Reilly, Neil J.

IPC分类号： C07C229/56 ,  C07C227/04 ,  C07D209/48

CPC分类号： C07D209/48 ,  C07C227/12 ,  C07C229/56

摘要： Disclosed is a method of making ionized fluoroanthranilic acid from a fluorophthalic compound in a single pot process without isolating any intermediate product. A composition is prepared which which comprises an aqueous solution of water, a fluorophthalic compound selected from the group consisting of
and mixtures thereof, where "n" is 1 to 4, at a concentration of about 5 to about 30 percent by weight based on the water weight, and about 1 to about 1.5 equivalents of hydroxylamine or a mineral acid salt thereof. The pH of the composition is maintained at at least about 11 and the temperature of the composition is maintained at at least about 90°C. The unionized form of the acid is made by cooling below 50°C and lowering the pH to between about 4 and about 5. Also disclosed are the intermediate compounds, fluoro-N-hydroxyphthalimides, and a method of making them.

摘要翻译： 公开了一种在单罐方法中从氟代邻苯二甲酸化合物制备离子化的邻氨苯甲酸的方法，而不分离任何中间产物。 制备组合物，其包含水的水溶液，选自下列的氟代邻苯二甲酸化合物及其混合物，其中“n”为1至4，浓度为约5至约30重量％ 基于水重量，以及约1至约1.5当量的羟胺或其无机酸盐。 将组合物的pH保持在至少约11℃，并将组合物的温度保持在至少约90℃。通过在50℃以下冷却并将pH降低至约4℃来制备酸的结合形式 还公开了中间体化合物，氟-N-羟基邻苯二甲酰亚胺及其制备方法。

公开(公告)号：EP0367232A3

公开(公告)日：1990-11-07

申请号：EP89120204.6

申请日：1989-10-31

申请人： OCCIDENTAL CHEMICAL CORPORATION

发明人： O'Reilly, Neil J. ,  Sojka, Stanley A. ,  Lin, Henry C.

IPC分类号： C07C211/27 ,  C07C209/62

CPC分类号： C07C209/62

摘要： 2-Chlorobenzylamine is prepared from 2-chlorobenzylchloride in a two-step process. In the first step, 2-chlorobenzylchloride is reacted with alkali metal phthalimide, preferably formed in situ from potassium carbonate and phthalimide, to form the novel intermediate 2-chlorobenzylphthalimide. In the second step, the phthalimide ring of the 2-chlorobenzylphthalimide is cleaved to form 2-chlorobenzylamine.

公开(公告)号：EP0495426A2

公开(公告)日：1992-07-22

申请号：EP92100430.5

申请日：1992-01-13

申请人： OCCIDENTAL CHEMICAL CORPORATION

发明人： Fertel, Lawrence B. ,  O'Reilly, Neil J. ,  Lin, Henry C.

IPC分类号： C07C51/41 ,  C07C51/00 ,  C07C63/68

CPC分类号： C07D209/48 ,  C07C51/00 ,  C07C63/68

摘要： Polychlorophthalimides, specifically, N-substituted tetrachlorophthalimides and N-substituted trichlorophthalimides may be treated with zinc and a base in aqueous solution to yield, after acidification, the product 3,5-dichlorophthalic acid or salts thereof.

摘要翻译： 聚氯邻苯二酰亚胺，特别是N-取代的四氯邻苯二甲酰亚胺和N-取代的三氯邻苯二甲酰亚胺可以用锌和碱在水溶液中处理，酸化后得到产物3,5-二氯邻苯二甲酸或其盐。

公开(公告)号：EP0367233A3

公开(公告)日：1990-07-11

申请号：EP89120205.3

申请日：1989-10-31

申请人： OCCIDENTAL CHEMICAL CORPORATION

发明人： O'Reilly, Neil J. ,  Lin, Henry C.

IPC分类号： C07D333/20 ,  C07D333/58

CPC分类号： C07D333/58 ,  C07D333/20

摘要： The present invention provides a process for the preparation of 2-(2-thienyl)-ethylamine and derivatives thereof having the general formula:
wherein R₁ and R₂ are hydrogen or taken together form a phenyl ring.

公开(公告)号：EP0367233A2

公开(公告)日：1990-05-09

申请号：EP89120205.3

申请日：1989-10-31

申请人： OCCIDENTAL CHEMICAL CORPORATION

发明人： O'Reilly, Neil J. ,  Lin, Henry C.

IPC分类号： C07D333/20 ,  C07D333/58

CPC分类号： C07D333/58 ,  C07D333/20

摘要： The present invention provides a process for the preparation of 2-(2-thienyl)-ethylamine and derivatives thereof having the general formula:
wherein R₁ and R₂ are hydrogen or taken together form a phenyl ring.

摘要翻译： 本发明提供了制备具有以下通式的2-（2-噻吩基） - 乙胺及其衍生物的方法：其中R 1和R 2是氢或一起形成苯环。

公开(公告)号：EP0495426A3

公开(公告)日：1992-10-21

申请号：EP92100430.5

申请日：1992-01-13

申请人： OCCIDENTAL CHEMICAL CORPORATION

发明人： Fertel, Lawrence B. ,  O'Reilly, Neil J. ,  Lin, Henry C.

IPC分类号： C07C51/41 ,  C07C51/00 ,  C07C63/68

CPC分类号： C07D209/48 ,  C07C51/00 ,  C07C63/68

摘要： Polychlorophthalimides, specifically, N-substituted tetrachlorophthalimides and N-substituted trichlorophthalimides may be treated with zinc and a base in aqueous solution to yield, after acidification, the product 3,5-dichlorophthalic acid or salts thereof.

公开(公告)号：EP0431294A3

公开(公告)日：1992-02-05

申请号：EP90120298.6

申请日：1990-10-23

申请人： OCCIDENTAL CHEMICAL CORPORATION

发明人： O'Reilly, Neil J. ,  Derwin, William S. ,  Lin, Henry C.

IPC分类号： C07C51/38

CPC分类号： C07C51/38 ,  C07C63/70

摘要： It has been discovered that 3,4,6-trifluorophthalic anhydride may be decarboxylated by heating in a polar aprotic solvent to yield 2,4,5-trifluorobenzoic acid.

公开(公告)号：EP0429848A3

公开(公告)日：1992-02-05

申请号：EP90120297.8

申请日：1990-10-23

申请人： OCCIDENTAL CHEMICAL CORPORATION

发明人： Fertel, Lawrence B. ,  O'Reilly, Neil J.

IPC分类号： C07C51/38

CPC分类号： C07C51/38 ,  C07C63/70

摘要： 4,5-Difluorophthalic anhydride and 4,5-difluorophthalic acid may be decarboxylated in high yield to 3,4-difluorobenzoic acid by heating in N-methyl-2-pyrrolidone or dimethyl acetamide using copper, copper oxide, copper salts, or halides and salts of Zn, Cd, Ag and Ni as a catalyst.

公开(公告)号：EP0431294A2

公开(公告)日：1991-06-12

申请号：EP90120298.6

申请日：1990-10-23

申请人： OCCIDENTAL CHEMICAL CORPORATION

发明人： O'Reilly, Neil J. ,  Derwin, William S. ,  Lin, Henry C.

IPC分类号： C07C51/38

CPC分类号： C07C51/38 ,  C07C63/70

摘要： It has been discovered that 3,4,6-trifluorophthalic anhydride may be decarboxylated by heating in a polar aprotic solvent to yield 2,4,5-trifluorobenzoic acid.

摘要翻译： 已经发现3,4,6-三氟邻苯二甲酸酐可以通过在极性非质子溶剂中加热而脱羧，得到2,4,5-三氟苯甲酸。

公开(公告)号：EP0429848A2

公开(公告)日：1991-06-05

申请号：EP90120297.8

申请日：1990-10-23

申请人： OCCIDENTAL CHEMICAL CORPORATION

发明人： Fertel, Lawrence B. ,  O'Reilly, Neil J.

IPC分类号： C07C51/38

CPC分类号： C07C51/38 ,  C07C63/70

摘要： 4,5-Difluorophthalic anhydride and 4,5-difluorophthalic acid may be decarboxylated in high yield to 3,4-difluorobenzoic acid by heating in N-methyl-2-pyrrolidone or dimethyl acetamide using copper, copper oxide, copper salts, or halides and salts of Zn, Cd, Ag and Ni as a catalyst.

摘要翻译： 通过使用铜，氧化铜，铜盐或卤化物在N-甲基-2-吡咯烷酮或二甲基乙酰胺中加热，可以高收率地将4,5-二氟邻苯二甲酸酐和4,5-二氟邻苯二甲酸脱羧成3,4-二氟苯甲酸 以及Zn，Cd，Ag和Ni的盐作为催化剂。