公开(公告)号：EP2683740A4

公开(公告)日：2014-12-03

申请号：EP12754203

申请日：2012-03-09

申请人： OMEROS CORP

发明人： LEPPARD JOHN BENJAMIN ,  WOOD CHRISTI L ,  CUMMINGS W JASON ,  YABUKI MUNEHISA ,  MAIZELS NANCY ,  ALLISON DANIEL S ,  TJOELKER LARRY W

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  C07K16/30

CPC分类号： C07K16/30 ,  C07K16/2878 ,  C07K2317/14 ,  C07K2317/23 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/77 ,  C07K2317/92 ,  C07K2319/55

摘要： The present invention relates generally to anti-FN14 antibodies. In particular, the anti-FN14 antibodies described herein are useful for the treatment of diseases, such as a variety of cancers, associated with expression of FN14.

摘要翻译： 本发明一般涉及抗FN14抗体。 特别地，本文所述的抗FN14抗体可用于治疗与FN14表达相关的疾病，例如多种癌症。

公开(公告)号：EP2968546A4

公开(公告)日：2016-11-02

申请号：EP14764165

申请日：2014-03-14

申请人： OMEROS CORP

发明人： CUMMINGS W JASON ,  GRAY PATRICK ,  TJOELKER LARRY W ,  YABUKI MUNEHISA

IPC分类号： A61K39/395 ,  C07K14/81 ,  C07K16/40

CPC分类号： C07K16/40 ,  A61K2039/505 ,  C07K14/811 ,  C07K16/00 ,  C07K2317/21 ,  C07K2317/23 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2318/10 ,  C07K2319/00 ,  C07K2319/30

公开(公告)号：EP2825652A4

公开(公告)日：2015-10-07

申请号：EP13761578

申请日：2013-03-13

申请人： OMEROS CORP ,  UNIV WASHINGTON CT COMMERCIALI

发明人： CUMMINGS W JASON ,  TJOELKER LARRY W ,  WOOD CHRISTI L ,  YABUKI MUNEHISA ,  ALLISON DANIEL S ,  LEPPARD JOHN B ,  MAIZELS NANCY

IPC分类号： C12N15/63 ,  C12N15/13 ,  C12N15/70 ,  C12N15/79

CPC分类号： C12N15/1082 ,  C07K16/00 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/92

摘要： The disclosure relates generally to the targeting of genes to, and their integration into, an immunoglobulin (antibody) heavy chain locus. In particular, the methods described herein contemplate replacing the single rearranged heavy chain V, D, and J genes of a B cell lymphoma such as DT40 with independently rearranged VH-D-JH genes of chicken, in a system for generating immunoglobulin diversity. Also contemplated is replacement of the chicken VH-D-JH with rearranged VH-D-JH genes of other vertebrates including human in a system for generating immunoglobulin diversity, with the exception of any substitution disclosed and claimed in PCT application WO 2009/029315 A2. Also described is construction of a diverse chicken immunoglobulin heavy chain VDJ library in DT40 by homologous gene replacement of the single endogenous rearranged VDJ gene with a chicken VDJ repertoire using the described targeting vectors.

摘要翻译： 本公开一般涉及基因的靶向，并且与免疫球蛋白（抗体）重链基因座的融合。 特别地，本文描述的方法考虑在用于产生免疫球蛋白多样性的系统中将具有独立重排的鸡的VH-D-JH基因的B细胞淋巴瘤（例如DT40）的单重排列重链V，D和J基因替换为独立重排的VH-D-JH基因。 还考虑到除了用于产生免疫球蛋白多样性的系统中，包括人的其它脊椎动物的重排的VH-D-JH基因的鸡VH-D-JH的替换，除了PCT申请WO 2009/029315A2中公开和要求的任何替代物 。 还描述了通过使用所述靶向载体与单个内源重排的VDJ基因与鸡VDJ库的同源基因替换来构建DT40中的多种鸡免疫球蛋白重链VDJ文库。

公开(公告)号：EP2742067A4

公开(公告)日：2015-03-04

申请号：EP12824632

申请日：2012-08-09

申请人： OMEROS CORP

发明人： CUMMINGS W JASON ,  YABUKI MUNEHISA ,  LEPPARD JOHN BENJAMIN ,  WOOD CHRISTI L ,  MAIZELS NANCY ,  ALLISON DANIEL S ,  TJOELKER LARRY W

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2896 ,  A61K39/39558 ,  A61K45/06 ,  A61K47/6825 ,  A61K47/6849 ,  A61K47/6851 ,  A61K2039/505 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/30 ,  C07K2317/23 ,  C07K2317/24 ,  C07K2317/732 ,  C07K2317/76 ,  C07K2317/92

摘要： The present invention relates generally to anti-FZD10 antibodies and to methods of using anti-FZD10 antibodies. In particular, the anti-FZD10 antibodies described herein are useful for altering one or more of survival, replication, differentiation and epithelial-to-mesenchymal cell transition of embryonic stem cells and/or for the treatment of diseases, such as a variety of cancers, associated with expression of FZD10, including as stand-alone therapies and in combination therapies with other agents.